Zobrazeno 1 - 10
of 21
pro vyhledávání: '"E F da Cruz e Silva"'
Autor:
Margarida Fardilha, O. A. B. da Cruz e Silva, Luís Korrodi-Gregório, Sara L. C. Esteves, E. F. da Cruz e Silva
Publikováno v:
Current Medicinal Chemistry. 17:3996-4017
Protein phosphorylation is a major regulatory mechanism of signal transduction cascades in eukaryotic cells, catalysed by kinases and reversed by protein phosphatases (PPs). Sequencing of entire genomes has revealed that ~3% of all eukaryotic genes e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ff2ad2d605ecefe7358de891360032
https://doi.org/10.2174/092986710793205363
https://doi.org/10.2174/092986710793205363
Publikováno v:
Biochemistry and Molecular Biology Education. 38:65-69
A multi-method active learning approach (MALA) was implemented in the Medical Biochemistry teaching unit of the Biomedical Sciences degree at the University of Aveiro, using problem-based learning as the main learning approach. In this type of learni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c351eec6ffb1f1c90cee1bc7b13f7a6f
https://doi.org/10.1002/bmb.20330
https://doi.org/10.1002/bmb.20330
Autor:
Hermann Esselmann, Jens Wiltfang, Sandra Vieira, Sandra Rebelo, O. A. B. da Cruz e Silva, E. F. da Cruz e Silva
Publikováno v:
Journal of Molecular Neuroscience. 32:1-8
The neurotoxic Abeta peptide is derived by proteolytic processing from the Alzheimer's amyloid precursor protein (APP), whose short cytoplasmic domain contains several phosphorylatable amino acids. The latter can be phosphorylated 'in vitro' and 'in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1462fd913ec037c2955cbd32856c18a8
https://doi.org/10.1007/s12031-007-0001-z
https://doi.org/10.1007/s12031-007-0001-z
Autor:
O. A. B. da Cruz e Silva, Cristina Varino Sousa, Ana Paula Vintém, E. F. da Cruz e Silva, Margarida Fardilha
Publikováno v:
Microscopy and Microanalysis. 14:134-136
Protein phosphatase 1 (PPP1) is the PPP most ubiquitous and each isoform interact with regulatory subunits that may be responsible for their subcellular localization. We identified PPP1R15B, C1ORF71 as novel regulators and the aim of this study was t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c1e688bed46bb149d84b5eb018f2e19
https://doi.org/10.1017/s1431927608089654
https://doi.org/10.1017/s1431927608089654
Autor:
E. F. da Cruz e Silva, Margarida Fardilha, O. A. B. da Cruz e Silva, Cristina Varino Sousa, Ana Paula Vintém
Publikováno v:
Microscopy and Microanalysis. 14:141-143
In testis we find mainly PPP1gamma2 isoform. We hypothesize that in different cell types we can find different regulatory subunits that may constitute targets for therapeutics of diseases such as male infertility, cancer and Alzheimer's disease. We i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e27af76c297d695621c61ed2a3578d98
https://doi.org/10.1017/s143192760808968x
https://doi.org/10.1017/s143192760808968x
Publikováno v:
Microscopy and Microanalysis. 21:26-27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::313ed2114b7dc2894e5a35c2bda51c80
https://doi.org/10.1017/s1431927614013804
https://doi.org/10.1017/s1431927614013804
Autor:
Balwant Khatra, K. Trautman, Gary D. Smith, Srinivasan Vijayaraghavan, D T Stephens, Paul Greengard, E F da Cruz e Silva
Publikováno v:
Biology of Reproduction. 54:709-718
Immotile bovine caput epididymal sperm contain levels of protein phosphatase activity twofold higher than do mature motile caudal sperm. Comparison of the inhibition profiles of endogenous phosphatase activities detected by okadaic acid (OA) and caly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32fcf769e3c050899c7fc3c32ffa38d6
https://doi.org/10.1095/biolreprod54.3.709
https://doi.org/10.1095/biolreprod54.3.709
Autor:
Paul Greengard, Don P. Wolf, Srinivasan Vijayaraghavan, E F da Cruz e Silva, K. Trautman, Gary D. Smith
Publikováno v:
Biology of Reproduction. 54:719-727
Sperm motility initiation, capacitation, and hyperactivation are modulated by an interplay of intracellular Ca 2+ , cAMP, and pH. Mechanisms by which these mediators alter sperm function have not been elucidated but may involve reversible alterations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfeaf9c966e368f195e2f6e7b120b555
https://doi.org/10.1095/biolreprod54.3.719
https://doi.org/10.1095/biolreprod54.3.719
Publikováno v:
American Journal of Physiology-Renal Physiology. 269:F673-F680
Previous studies of hormonal regulation of renal Na(+)-K(+)-ATPase have indicated that the activity of the sodium pump is regulated by phosphorylation-dephosphorylation reactions. Here we report that okadaic acid (OA) and calyculin A (CL-A), inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d94dd0e276f6be5bd865228cada04c9
https://doi.org/10.1152/ajprenal.1995.269.5.f673
https://doi.org/10.1152/ajprenal.1995.269.5.f673
Autor:
Paul Greengard, E F da Cruz e Silva, Norbert Berndt, D A Carbonaro-Hall, M Dohadwala, Frederick L. Hall, Angus C. Nairn, R T Williams
Publikováno v:
Scopus-Elsevier
Protein phosphatase 1 and protein phosphatase 2A contain potential phosphorylation sites for cyclin-dependent kinases. In the present study we found that rabbit skeletal muscle protein phosphatase 1, as well as recombinant protein phosphatase 1 alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d19b0408329c73d4642e42be7a6047b
https://doi.org/10.1073/pnas.91.14.6408
https://doi.org/10.1073/pnas.91.14.6408