Zobrazeno 1 - 10
of 24
pro vyhledávání: '"E F Nemeth"'
Autor:
E. F. Nemeth, W. G. Goodman
Publikováno v:
Calcified tissue international. 98(4)
The actions of extracellular Ca(2+) in regulating parathyroid gland and kidney functions are mediated by the extracellular calcium receptor (CaR), a G protein-coupled receptor. The CaR is one of the essential molecules maintaining systemic Ca(2+) hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c707edb443123d0dd75b666d6345de1
https://pubmed.ncbi.nlm.nih.gov/26319799
https://pubmed.ncbi.nlm.nih.gov/26319799
Autor:
E. F. Nemeth, F. K. Racke
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 267:E429-E438
The role of protein kinase C (PKC) in regulating cytosolic Ca2+ concentrations ([Ca2+]i) and parathyroid hormone (PTH) secretion was studied in bovine parathyroid cells rendered deficient in PKC activity by incubation with phorbol 12-myristate 13-ace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b2860eb53fb0327028004a87d793a2
https://doi.org/10.1152/ajpendo.1994.267.3.e429
https://doi.org/10.1152/ajpendo.1994.267.3.e429
Autor:
F K Racke, E F Nemeth
Publikováno v:
The Journal of Physiology. 468:163-176
1. The role of protein kinase C (PKC) in the regulation of parathyroid hormone (PTH) secretion was examined in dissociated bovine parathyroid cells. 2. Increasing the concentration of extracellular Ca2+ from 0.5 to 2 mM inhibited PTH secretion by 60-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79681ed9dbc239cad61012980f154491
https://doi.org/10.1113/jphysiol.1993.sp019765
https://doi.org/10.1113/jphysiol.1993.sp019765
Autor:
F K Racke, E F Nemeth
Publikováno v:
The Journal of Physiology. 468:141-162
1. The effects of protein kinase C (PKC) activators and inhibitors on the mechanisms regulating cytosolic Ca2+ homeostasis in dissociated bovine parathyroid cells loaded with fura-2 were examined. 2. Stepwise increases in the concentration of extrace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e772f79c51ddb53f0a11e91e14dbd90b
https://doi.org/10.1113/jphysiol.1993.sp019764
https://doi.org/10.1113/jphysiol.1993.sp019764
Autor:
E F, Nemeth
Publikováno v:
Journal of musculoskeletalneuronal interactions. 4(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::acb980a310ae111e05499cd3c6271d69
https://pubmed.ncbi.nlm.nih.gov/15758288
https://pubmed.ncbi.nlm.nih.gov/15758288
Autor:
E F Nemeth
Publikováno v:
Current pharmaceutical design. 8(23)
Parathyroid hormone (PTH) is the key endocrine factor regulating systemic Ca(2+) homeostasis. Elevated levels of circulating PTH increase bone turnover and, depending on the duration of elevation, will result in net anabolic or catabolic effects on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bfda918c384f28874b25f02afd4a79
https://pubmed.ncbi.nlm.nih.gov/12171519
https://pubmed.ncbi.nlm.nih.gov/12171519
Autor:
E F, Nemeth, E G, Delmar, W L, Heaton, M A, Miller, L D, Lambert, R L, Conklin, M, Gowen, J G, Gleason, P K, Bhatnagar, J, Fox
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(1)
Despite the discovery of many ions and molecules that activate the Ca2+ receptor, there are no known ligands that block this receptor. Reported here are the pharmacodynamic properties of a small molecule, NPS 2143, which acts as an antagonist at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0ba77477c50c13fed183008c55123b5
https://pubmed.ncbi.nlm.nih.gov/11561095
https://pubmed.ncbi.nlm.nih.gov/11561095
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(2)
N-(3-[2-Chlorophenyl]propyl)-(R)-alpha-methyl-3-methoxybenzylamine (NPS R-568) is an orally active compound that activates Ca(2+) receptors on parathyroid cells and rapidly suppresses plasma levels of parathyroid hormone (PTH) and Ca(2+) (ED(50), 1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7aec3039bef6bc41783bc05dad7ed383
https://pubmed.ncbi.nlm.nih.gov/10411553
https://pubmed.ncbi.nlm.nih.gov/10411553
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(2)
Calcimimetics like N-(3-[2-chlorophenyl]propyl)-(R)-alpha-methyl-3-methoxybenzylamine (NPS R-568) potentiate the effects of extracellular Ca(2+) on parathyroid Ca(2+) receptors and inhibit parathyroid hormone (PTH) secretion in vitro. When administer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a6943444c6185d2bae74e99b812f34c
https://pubmed.ncbi.nlm.nih.gov/10411552
https://pubmed.ncbi.nlm.nih.gov/10411552
Autor:
L G, Hammerland, K J, Krapcho, J E, Garrett, N, Alasti, B C, Hung, R T, Simin, C, Levinthal, E F, Nemeth, F H, Fuller
Publikováno v:
Molecular pharmacology. 55(4)
The Ca2+ receptor is a G protein-coupled receptor that enables parathyroid cells and certain other cells in the body to respond to changes in the level of extracellular Ca2+. The Ca2+ receptor is a member of a family of G protein-coupled receptors th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e0c04b7f7d471a81dcebe5f13382ab77
https://pubmed.ncbi.nlm.nih.gov/10101021
https://pubmed.ncbi.nlm.nih.gov/10101021