Zobrazeno 1 - 10
of 13
pro vyhledávání: '"E F, Usac"'
Autor:
M. Barbacid, Conchi Mora, Carmen Franco, Javier Martín, E F Usac, Nuria Marzo, Marta E Fabregat, Roger R. Gomis
Publikováno v:
Diabetologia. 47:686-694
Cyclin-dependent kinase 4 (Cdk4) is crucial for beta cell development. A mutation in the gene encoding for Cdk4, Cdk4R24C, causes this kinase to be insensitive to INK4 cell cycle inhibitors and induces beta cell hyperplasia in Cdk4R24C knockin mice.
Publikováno v:
Journal of Clinical Immunology. 23:107-118
A human B cell clone, EBV-MB91, producing IgMλ islet cell autoantibody (ICA), obtained by Epstein–Barr virus (EBV) transformation of peripheral CD5− surface Ig+ B cells from a Type 1 diabetic child, and an EBV-MB91-derived hetrohybridoma, HY-MB9
Autor:
Monica Gudayol, Albert Morales, E F Usac, José C. Fernández-Checa, Ramon Gomis, Josep Vidal, Marta E Fabregat, Anna Novials
Publikováno v:
Endocrine. 16:39-42
Ca2+-responsive mitochondrial FAD-linked glycerophosphate dehydrogenase (mGPDH) is a key component of the pancreatic beta-cell glucose-sensing device. The purpose of this study was to examine the association of mutations in the cDNA coding for the FA
Autor:
M Gudayol, Jose M. Vidal-Taboada, Rafael Oliva, C dell'Anna, A Costa, Roger R. Gomis, P Cristòbal, E F Usac
Publikováno v:
Biochemical and Biophysical Research Communications. 263:439-445
To evaluate if potential defects in the FAD-binding domain of the mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH) gene could contribute to susceptibility to type 2 diabetes mellitus, we have screened 151 type 2 DM patients for mutations usin
Publikováno v:
Biochemical and Biophysical Research Communications. 252:173-177
COS-7 cells were transfected with the green fluorescent protein (GFP) ofAequorea victoria,human mitochondrial FAD-linked glycerophosphate dehydrogenase (mGDH), a mGDHwt-EGFP construct, or two mutant mGDH-proteins fused with EGFP. The site of mutation
Autor:
Susan D. Arden, Gaby Duinkerken, R. R. P. De Vries, Bart O. Roep, E. F. Usac, John C. Hutton, Pavlos Neophytou
Publikováno v:
Journal of Clinical Investigation. 97:551-561
Cell-mediated autoimmune attack directed against islet proteins of approximately 38 kD in size has been associated with type 1 diabetes. A novel murine cDNA encoding an antigen of this size was cloned using a screening procedure based on the prolifer
Autor:
Kevin Docherty, Kathleen I.J. Shennan, John C. Hutton, E. F. Usac, E M Bailyes, Paul C. Guest, Susan D. Arden
Publikováno v:
Biochemical Journal. 309:587-594
Human prohormone convertase PC2 was expressed in Xenopus oocytes and its properties were compared with those of the Type-2 endopeptidase of rat insulin secretory granules, previously identified as PC2 [Bennett, Bailyes, Nielson, Guest, Rutherford, Ar
Autor:
Roger R. Gomis, E F Usac, J. Barceló, Nuria Somoza, Teresa Gallart, Odette Viñas, A. Muñoz, Josefa Fernandez-Álvarez
Publikováno v:
Diabetologia. 38:62-72
Although CD5 + B lymphocytes are mostly committed to the production of polyreactive natural autoantibodies, CD5 + B lymphocytes committed to the production of somatically mutated and monoreactive high-affinity IgM autoantibodies have been also shown.
Publikováno v:
Diabetologia. 44(8)
Publikováno v:
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 32(3)