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Relationship between cytokine-dependent cell cycle progression and MHC class II antigen expression by human CD34+ HLA-DR- bone marrow cells

Autor: E F Srour, J E Brandt, T Leemhuis, C B Ballas, R Hoffman

Publikováno v: The Journal of Immunology. 148:815-820

Human CD34+ HLA-DR- bone marrow cells constitute a phenotypically homogeneous population of quiescent cells. More than 97% of CD34+ HLA-DR- cells reside in the G0/G1 phase of the cell cycle. The in vitro effects of two cytokines, IL-1 alpha and IL-3,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc56090f555a77ec36367f429a82a0a7
https://doi.org/10.4049/jimmunol.148.3.815

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Role of c-kit ligand in the expansion of human hematopoietic progenitor cells

Autor: J, Brandt, R A, Briddell, E F, Srour, T B, Leemhuis, R, Hoffman

Publikováno v: Blood. 79:634-641

To test the hypothesis that the c-kit ligand plays an important role in the regulation of early events occurring during human hematopoiesis, we determined the effect of a recombinant form of c-kit ligand, termed mast cell growth factor (MGF), on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87a7df5c4822d796e05af46e83fa430
https://doi.org/10.1182/blood.v79.3.634.bloodjournal793634

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Autor: J, Wilpshaar, J H, Falkenburg, X, Tong, W A, Noort, R, Breese, D, Heilman, H, Kanhai, C M, Orschell-Traycoff, E F, Srour

Publikováno v: Blood. 96(6)

It was hypothesized that during mammalian development, the extensive need for hematopoietic cells requires equal contribution to blood cell production from both quiescent and cycling hematopoietic stem cells (HSCs) while maintaining the stem cell poo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14ef2e508544ee2981fc9df1890d7ca9
https://pubmed.ncbi.nlm.nih.gov/10979954

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Homing and engraftment potential of Sca-1(+)lin(-) cells fractionated on the basis of adhesion molecule expression and position in cell cycle

Autor: C M, Orschell-Traycoff, K, Hiatt, R N, Dagher, S, Rice, M C, Yoder, E F, Srour

Publikováno v: Blood. 96(4)

Engraftment potential of hematopoietic stem cells (HSCs) is likely to be dependent on several factors including expression of certain adhesion molecules (AMs) and degree of mitotic quiescence. The authors investigated the functional properties and en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99cabbed5eab10d43879c314c9d5432f
https://pubmed.ncbi.nlm.nih.gov/10942381

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Expression and functional characterization of the beta-isoform of the folate receptor on CD34(+) cells

Autor: J A, Reddy, L S, Haneline, E F, Srour, A C, Antony, D W, Clapp, P S, Low

Publikováno v: Blood. 93(11)

We have investigated the expression and functional competence of folate receptor (FR) isoforms on human hematopoietic cells. Using immunofluorescence and reverse transcriptase-polymerase chain reaction (RT-PCR) methodology, we find that a substantial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::731d0e804ee87149fcce279fc3c8c24e
https://pubmed.ncbi.nlm.nih.gov/10339503

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Gene Marking in Bone Marrow and Peripheral Blood Stem Cell Transplantation

Autor: E. F. Srour, C. M. Traycoff, K. Cornetta

Publikováno v: Gene Therapy ISBN: 9783034870139

In this chapter we will evaluate the use of genetic marking in autologous bone marrow transplantation. After identifying the controversial issues in the field, clinical studies using gene-marked bone marrow will be reviewed and discussed in the conte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::160b1b045d688740bcf3e7bd266abaa5
https://doi.org/10.1007/978-3-0348-7011-5_12

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Autor: A, Gothot, J C, van der Loo, D W, Clapp, E F, Srour

Publikováno v: Blood. 92(8)

Most primitive hematopoietic progenitor cells reside in vivo within the G0/G1 phase of the cell cycle. By simultaneous DNA/RNA staining it is possible to distinguish G0 and G1 states and to isolate cells in defined phases of the cell cycle. We report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f53a2077aedffa0e4774b38b4d5a34b
https://pubmed.ncbi.nlm.nih.gov/9763545

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Chronic myelogenous leukaemia CD34+ cells exit G0/G1 phases of cell cycle more rapidly than normal marrow CD34+ cells

Autor: C M, Traycoff, B, Halstead, S, Rice, J, McMahel, E F, Srour, K, Cornetta

Publikováno v: British journal of haematology. 102(3)

To investigate the mechanisms behind the leukaemic expansion of chronic myelogenous leukaemia (CML), we examined the cell cycle status and activation kinetics of purified subpopulations of CD34+ cells from normal and CML bone marrow (BM). Propidium i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::945be3cd2134b5bc07c41419e8f7ce16
https://pubmed.ncbi.nlm.nih.gov/9722304

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Assessment of proliferative and colony-forming capacity after successive in vitro divisions of single human CD34+ cells initially isolated in G0

Autor: A, Gothot, R, Pyatt, J, McMahel, S, Rice, E F, Srour

Publikováno v: Experimental hematology. 26(7)

Exit of primitive hematopoietic progenitor cells (HPCs) from the G0 phase of the cell cycle in response to in vitro cytokine stimulation is a limiting step in successful ex vivo expansion. Simultaneous DNA/RNA staining with Hoechst 33342 and pyronin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98d87bcb7aa98a0a311a9b0bc0f2074b
https://pubmed.ncbi.nlm.nih.gov/9657130

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