Zobrazeno 1 - 10
of 552
pro vyhledávání: '"E Escher"'
Autor:
Matthias M. Wehr, Stella Marie Reamon-Buettner, Detlef Ritter, Jan Knebel, Monika Niehof, Sylvia E. Escher
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Next-generation risk assessment relies on mechanistic data from new approach methods, including transcriptome data. Various technologies, such as high-throughput targeted sequencing methods and microarray technologies based on hybridization
Externí odkaz:
https://doaj.org/article/11e16239a00c42b6a2cfd059b284d4dc
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
For many industrial chemicals toxicological data is sparse regarding several regulatory endpoints, so there is a high and often unmet demand for NAMs that allow for screening and prioritization of these chemicals. In this proof of concept case study
Externí odkaz:
https://doaj.org/article/7824a62fc0ef41bfba6176412284a191
Substantiate a read-across hypothesis by using transcriptome data—A case study on volatile diketones
Autor:
Christina Drake, Matthias M. Wehr, Walter Zobl, Jeannette Koschmann, David De Lucca, Britta A. Kühne, Tanja Hansen, Jan Knebel, Detlef Ritter, Jan Boei, Harry Vrieling, Annette Bitsch, Sylvia E. Escher
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
This case study explores the applicability of transcriptome data to characterize a common mechanism of action within groups of short-chain aliphatic α-, β-, and γ-diketones. Human reference in vivo data indicate that the α-diketone diacetyl induc
Externí odkaz:
https://doaj.org/article/ef322cf5e85e456eb141e4eefa521a86
Autor:
Monika Batke, Fatemeh Moradi Afrapoli, Rupert Kellner, James F. Rathman, Chihae Yang, Mark T. D. Cronin, Sylvia E. Escher
Publikováno v:
Frontiers in Toxicology, Vol 3 (2021)
The Threshold of Toxicological Concern (TTC) concept can be applied to organic compounds with the known chemical structure to derive a threshold for exposure, below which a toxic effect on human health by the compound is not expected. The TTC concept
Externí odkaz:
https://doaj.org/article/94a1725ac32c45b78c0406d6254c6e57
Publikováno v:
Data in Brief, Vol 11, Iss C, Pp 204-207 (2017)
Hyperbilirubinemia is a pathological condition, very often indicative of underlying liver condition that is characterized by excessive accumulation of conjugated or unconjugated bilirubin in sinusoidal blood. In literature there are several indicatio
Externí odkaz:
https://doaj.org/article/43bc47672a4a4220879ea5d2c75155a0
Publikováno v:
Archives of Toxicology. 96:3033-3051
Valproic acid is a frequently used antiepileptic drug and known pediatric hepatotoxic agent. In search of pharmaceuticals with increased effectiveness and reduced toxicity, analogue chemicals came into focus. So far, toxicity and teratogenicity data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381140ef55e302a018dffe2751f3d7b0
https://doi.org/10.1007/s00204-022-03340-z
https://doi.org/10.1007/s00204-022-03340-z
Autor:
Oliver C. Gorton, Jutta E. Escher
Publikováno v:
Physical Review C. 107
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c0135ea672ea42fd0f95bec5fcb9793
https://doi.org/10.1103/physrevc.107.044612
https://doi.org/10.1103/physrevc.107.044612
Autor:
Joan Lewis-Wambi, Christy R. Hagan, Ossama Tawfik, Katherine R. Walter, Eric S. Geanes, Asona J. Lui, Taylor E. Escher
S1. E2 and GO-201 decrease IFITM1 expression. S2. Combination treatment with JAK/STAT inhibitor. S3. Alterations to IFITM1 expression upon MUC1 knockdown and Rux treatment. S4. Estrogen treatment reduces tumor size in Nude mice injected with MCF-7:5C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9353866a373f95b54e7722514cbcca1
https://doi.org/10.1158/1541-7786.22512468.v1
https://doi.org/10.1158/1541-7786.22512468.v1
Autor:
Joan Lewis-Wambi, Christy R. Hagan, Ossama Tawfik, Katherine R. Walter, Eric S. Geanes, Asona J. Lui, Taylor E. Escher
The human oncoprotein, mucin 1 (MUC1), drives tumorigenesis in breast carcinomas by promoting epithelial-to-mesenchymal transition (EMT), epigenetic reprogramming, and evasion of immune response. MUC1 interacts with STAT1, through JAK/STAT signaling,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a989f1c292dc7a8a06dc9b7efcafb3b0
https://doi.org/10.1158/1541-7786.c.6540249.v1
https://doi.org/10.1158/1541-7786.c.6540249.v1
The symposium “Computational and Group-Theoretical Methods in Nuclear Physics” was organized to celebrate the 60th birthday of Jerry P Draayer, who is Professor of Physics, Lousiana State University, and President of the Southeastern Universities