Zobrazeno 1 - 10
of 143
pro vyhledávání: '"E E Sercarz"'
Autor:
P. Van Den Elzen, Emanual Michael Maverakis, E. E. Sercarz, J. E. Miller, L. T. Madakamutil, Francesco Ria
Publikováno v:
Scopus-Elsevier
T lymphocytes play a central role in the pathogenesis of a large number of human conditions including autoimmunity and graft rejection. Although T cells are key players in mounting immune responses, the assessment of T cell repertoires has yet to fin
Publikováno v:
The Journal of Immunology. 163:4232-4237
The T cell repertoire is shaped by the processes of positive and negative selection. We have previously shown that mice are tolerant to a native self-Ag, mouse lysozyme (ML), but they respond vigorously when challenged with different ML peptides (“
Publikováno v:
Clinical and Experimental Immunology. 114:166-172
SUMMARYIt is now becoming accepted that one is not tolerant to all the determinants of self proteins: the T cell repertoire directed to some sequences in self proteins is intact and can be activated. When a self protein is exclusively expressed by tu
Publikováno v:
The Journal of Immunology. 159:2574-2579
T cell responses to different protein Ags have been shown to focus on a few ("immunodominant") determinants. We have addressed three major, interrelated questions regarding immunodominance. First, can each area within hen eggwhite lysozyme (HEL) serv
Publikováno v:
The Journal of Immunology. 153:938-945
Previously, we have demonstrated that during allograft rejection, MHC molecules of the donor are processed and presented to alloreactive CD4+ T lymphocytes in the form of peptides associated with the MHC class II molecules of the recipient. There is
Publikováno v:
The Journal of Immunology. 152:3711-3719
Recent experiments have shown that during the course of chronic experimental allergic encephalomyelitis, there is a shift in the determinant hierarchy away from the dominant to other subdominant and cryptic self determinants. It was therefore of inte
Publikováno v:
The Journal of Immunology. 151:5000-5010
The key event in the induction of an immune response is the recognition by a T lymphocyte of an antigenic peptide bound to a MHC molecule. In the absence of structural coordinates of the TCR and class II MHC molecules, various models of T cell recogn
Publikováno v:
European Journal of Immunology. 23:269-274
Human T helper cells can discriminate among strain variants of HIV gp120 because of T cell clones recognizing non-conserved regions, as demonstrated with T cells from HIV-infected individuals and vaccinated volunteers and with primary T cell lines an
Publikováno v:
The Journal of Immunology. 144:1571-1577
The specificity of lysozyme-induced T cell proliferative responses by individual B10.A mice was compared by using a panel of three peptides. A surprising degree of variation in the focus of the responses was observed among individual animals, both in
Publikováno v:
Current directions in autoimmunity. 4