Výsledky vyhledávání

Metabolism of 3,5,5-trimethylhexanoyl-ferrocene by rat liver: release of iron from 3,5,5-trimethylhexanoyl-ferrocene by a microsomal, phenobarbital-inducible cytochrome P-450

Autor: E E, Cable, H C, Isom

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 27(2)

3,5,5-Trimethylhexanoyl (TMH)-ferrocene has been used to produce iron loading in whole animals and in cultured hepatocytes. Iron loading produced by TMH-ferrocene is highly efficient and, of the compounds used to produce iron loading in experimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::43b89a6cb7ad443fc4fcb5173dc1ff19
https://pubmed.ncbi.nlm.nih.gov/9929512

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Accumulation of iron by primary rat hepatocytes in long-term culture: changes in nuclear shape mediated by non-transferrin-bound forms of iron

Autor: E E, Cable, J R, Connor, H C, Isom

Publikováno v: The American journal of pathology. 152(3)

We have previously shown that hepatocytes in long-term dimethylsulfoxide (DMSO) culture, fed a chemically defined medium, are highly differentiated and an excellent in vitro model of adult liver. Hepatocytes in long-term DMSO culture can be iron load

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::997c775b43ef9af02d26dafa78b00fdc
https://pubmed.ncbi.nlm.nih.gov/9502420

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Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: evidence against a stress-mediated response

Autor: E E, Cable, O S, Gildemeister, J A, Pepe, R W, Lambrecht, H L, Bonkovsky

Publikováno v: Molecular and cellular biochemistry. 169(1-2)

Heme oxygenase catalyzes the first and rate-controlling step in heme catabolism. One of the two forms of heme oxygenase (heme oxygenase-1) has been shown to be increased by heme, metals, and in some systems, by certain environmental stresses. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c41fe8d53e0f060859ba5d34f09dce37
https://pubmed.ncbi.nlm.nih.gov/9089626

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A detailed analysis of the Knodell score and other histologic parameters as predictors of response to interferon therapy in chronic hepatitis C

Autor: B F, Banner, A L, Barton, E E, Cable, L, Smith, H L, Bonkovsky

Publikováno v: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 8(3)

The Knodell score is inaccurate at predicting response to interferon alpha (IFN-alpha) therapy in patients with hepatitis C. Our aim was to see if specific histologic parameters, including iron deposition in liver biopsies, are better predictors of r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2343d8947d3844af990906a1515cbaa
https://pubmed.ncbi.nlm.nih.gov/7542385

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Tissue distribution of zinc-mesoporphyrin in rats: relationship to inhibition of heme oxygenase

Autor: S M, Russo, J A, Pepe, S, Donohue, E E, Cable, R W, Lambrecht, H L, Bonkovsky

Publikováno v: The Journal of pharmacology and experimental therapeutics. 272(2)

Metalloporphyrins, including heme and others that inhibit heme oxygenase, are agents with expanding therapeutic potential. Recent results from our laboratory showed that a combination of heme and zinc-mesoporphyrin was remarkably effective in amelior

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed9aff55eaf984f15a821c2b8f1eb083
https://pubmed.ncbi.nlm.nih.gov/7853192

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Repression of hepatic delta-aminolevulinate synthase by heme and metalloporphyrins: relationship to inhibition of heme oxygenase

Autor: E E, Cable, J W, Cable, H L, Bonkovsky

Publikováno v: Hepatology (Baltimore, Md.). 18(1)

Heme- and tin-chelated metalloporphyrins are known to decrease the activity of hepatic delta-amino-levulinate synthase, the rate-controlling enzyme of heme synthesis. We performed experiments in primary chick embryo liver cells with tin-, zinc- and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbd83f2b7ea146695bfe877c809c1028
https://pubmed.ncbi.nlm.nih.gov/8325603

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Porphyrogenic properties of the terpenes camphor, pinene, and thujone (with a note on historic implications for absinthe and the illness of Vincent van Gogh)

Autor: H L, Bonkovsky, E E, Cable, J W, Cable, S E, Donohue, E C, White, Y J, Greene, R W, Lambrecht, K K, Srivastava, V, van Gogh

Publikováno v: Biochemical pharmacology. 43(11)

Camphor, alpha-pinene (the major component of turpentine), and thujone (a constituent in the liqueur called absinthe) produced an increase in porphyrin production in primary cultures of chick embryo liver cells. In the presence of desferrioxamine (an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::575acf0b01cd81e4c11d96b459e3491c
https://pubmed.ncbi.nlm.nih.gov/1610401

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Akademický článek

High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C.

Autor: Clifford BD; Department of Medicine, University of Massachusetts Medical Center, Worcester 01655., Donahue D, Smith L, Cable E, Luttig B, Manns M, Bonkovsky HL

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 1995 Mar; Vol. 21 (3), pp. 613-9.

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Akademický článek

Mechanism of synergistic induction of hepatic heme oxygenase by glutethimide and iron: studies in cultured chick embryo liver cells.

Autor: Cable E; Department of Biochemistry, Emory University, Atlanta, GA 30322., Greene Y, Healey J, Evans CO, Bonkovsky H

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1990 Apr 16; Vol. 168 (1), pp. 176-81.

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