Abdominal subcutaneous and visceral adipocyte size, lipolysis and inflammation relate to insulin resistance in male obese humans

Autor: K. Verboven, K. Wouters, K. Gaens, D. Hansen, M. Bijnen, S. Wetzels, C. D. Stehouwer, G. H. Goossens, C. G. Schalkwijk, E. E. Blaak, J. W. Jocken

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)

Abstract Obesity is associated with a disturbed adipose tissue (AT) function characterized by adipocyte hypertrophy, an impaired lipolysis and pro-inflammatory phenotype, which contributes to insulin resistance (IR). We investigated whether AT phenot

Externí odkaz: https://doaj.org/article/443cd9ffd09742e6ad0690ce44450891

Improved Insulin Sensitivity With Angiotensin Receptor Neprilysin Inhibition in Individuals With Obesity and Hypertension

Autor: J, Jordan, R, Stinkens, T, Jax, S, Engeli, E E, Blaak, M, May, B, Havekes, C, Schindler, D, Albrecht, P, Pal, T, Heise, G H, Goossens, T H, Langenickel

Publikováno v: Clinical pharmacology and therapeutics. 101(2)

Natriuretic peptide (NP) deficiency and sustained renin-angiotensin system activation are associated with impaired oxidative metabolism and predispose to type-2 diabetes. We hypothesized that sacubitril/valsartan (LCZ696), which augments NP through n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eda9d793bdbdac503f4e3c0509ca68eb
https://pubmed.ncbi.nlm.nih.gov/27542885

Targeting fatty acid metabolism to improve glucose metabolism

Autor: R, Stinkens, G H, Goossens, J W E, Jocken, E E, Blaak

Publikováno v: Obesity reviews : an official journal of the International Association for the Study of Obesity. 16(9)

Disturbances in fatty acid metabolism in adipose tissue, liver, skeletal muscle, gut and pancreas play an important role in the development of insulin resistance, impaired glucose metabolism and type 2 diabetes mellitus. Alterations in diet compositi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f5c6ae47df2ae69af2a458e00cb59a56
https://pubmed.ncbi.nlm.nih.gov/26179344

Abstracts of papers clinical pharmacological meeting

Autor: M. M. Klauw, B. H. Ch. Stricker, J. P. Ottervanger, F. G. A. Meché, J. M. T. Griensven, H. H. P. J. Lemkes, J. M. Kroon, H. C. Schoemaker, A. F. Cohen, J. H. M. Schellens, W. Loos, B. Acker, M. Boer-Dennert, A. S. T. Planting, M. E. L. Burg, G. Stoter, R. Krediet, J. Verweij, E. E. Blaak, M. A. Baak, G. J. Kemerink, M. T. W. Pakbiers, G. A. K. Heidendal, W. H. M. Saris, S. Bouckaert, L. Vakaet, M. Dhont, J. P. Remon, S. A. J. Broek, P. A. Graeff, W. H. Gilst, D. J. Veldhuisen, H. L. Hillige, H. Wesseling, K. I. Lie, C. A. Gaillard, P. N. Es, P. W. Leeuw, L. M. A. B. Bortel, M. J. F. Kool, F. A. T. Lustermans, J. G. S. Breed, A. P. G. Hoeks, H. A. J. Struijker Boudier, R. P. Pickkers, P. Smits, H. Baadenhuysen, A. Laar, Th. Thien, M. M. Elseviers, M. E. Broe, A. J. A. M. Ven, P. P. Koopmans, W. H. M. Peters, T. B. Vree, J. W. M. Meer, E. Snoeck, A. Peer, M. Sack, M. Horton, G. Mannens, R. Woestenborghs, J. Heykants, R. Meibach, T. B. Witsen, H. A. Valkenburg, R. H. Stichele, B. Potter, P. Vyncke, M. G. Bogaert, J. Burggraaf, H. Wollersheim, J. Aalen, R. G. Schoemaker, X. Y. Du, W. A. Bax, E. Bos, P. R. Saxena, G. A. Rongen, P. N. M. Heiningen, H. R. Schwietert, J. M. Kortboyer, F. A. E. Sollie, C. Piraube, P. Desché, J. H. G. Jonkman, W. L. Blok, I. C. Gyssens, Y. A. Hekster, P. A. F. Jansen, R. C. Sival, J. F. Nieuwkerk, B. Klaverwiiden, E. A. Bruijn, O. Driessen

Publikováno v: Pharmacy World & Science. 15:1-7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef2aae6a441771cb628d57e3209c1802
https://doi.org/10.1007/bf01876624

Obesity and the lung: 5. Obesity and COPD

Autor: F M E, Franssen, D E, O'Donnell, G H, Goossens, E E, Blaak, A M W J, Schols

Publikováno v: Thorax. 63(12)

Chronic obstructive pulmonary disease (COPD) and obesity are common and disabling chronic health conditions with increasing prevalence worldwide. A relationship between COPD and obesity is increasingly recognised, although the nature of this associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3256847d6064a693b545f5eab1e5feba
https://pubmed.ncbi.nlm.nih.gov/19561286