Zobrazeno 1 - 10
of 91
pro vyhledávání: '"E Douglas Lewandowski"'
Autor:
Julianne H Grose, Kelsey Langston, Xiaohui Wang, Shayne Squires, Soumyajit Banerjee Mustafi, Whitney Hayes, Jonathan Neubert, Susan K Fischer, Matthew Fasano, Gina Moore Saunders, Qiang Dai, Elisabeth Christians, E Douglas Lewandowski, Peipei Ping, Ivor J Benjamin
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0133994 (2015)
Small Heat Shock Proteins (sHSPs) are molecular chaperones that transiently interact with other proteins, thereby assisting with quality control of proper protein folding and/or degradation. They are also recruited to protect cells from a variety of
Externí odkaz:
https://doaj.org/article/1aa7329692af4e7eac7ae8233e3ebade
Autor:
Tsunehisa Yamamoto, Santosh K. Maurya, Elizabeth Pruzinsky, Kirill Batmanov, Yang Xiao, Sarah M. Sulon, Tomoya Sakamoto, Yang Wang, Ling Lai, Kendra S. McDaid, Swapnil V. Shewale, Teresa C. Leone, Timothy R. Koves, Deborah M. Muoio, Pieterjan Dierickx, Mitchell A. Lazar, E. Douglas Lewandowski, Daniel P. Kelly
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
During the development of heart failure (HF), the capacity for cardiomyocyte (CM) fatty acid oxidation (FAO) and ATP production is progressively diminished, contributing to pathologic cardiac hypertrophy and contractile dysfunction. Receptor-interact
Externí odkaz:
https://doaj.org/article/73b6b8d5e2734d2b968b0ca4b0b2ae53
Publikováno v:
JACC: Basic to Translational Science. 8:422-435
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a07c102c2369b3dae7939db607b8c75
https://doi.org/10.1016/j.jacbts.2022.10.009
https://doi.org/10.1016/j.jacbts.2022.10.009
Publikováno v:
JACC: Basic to Translational Science. 7:730-742
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d41c88e0eab754d8d912d495c754f9d
https://doi.org/10.1016/j.jacbts.2021.12.010
https://doi.org/10.1016/j.jacbts.2021.12.010
Autor:
Azariyas Challa, Santosh Maurya, Yang Wang, Pablo Vidal Souza, Lisa Baer, Andrew Carley, Kristin Stanford, E. Douglas Lewandowski
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:122-123
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b77a57b44c9decfa65996cb7076d42f5
https://doi.org/10.1016/j.yjmcc.2022.08.240
https://doi.org/10.1016/j.yjmcc.2022.08.240
Autor:
Yang Wang, Matthew Fasano, Craig H. Selzman, Santosh K. Maurya, E. Douglas Lewandowski, Stavros G. Drakos, Andrew N. Carley
Publikováno v:
Circulation
Background: The failing heart is energy starved with impaired oxidation of long-chain fatty acids (LCFAs) at the level of reduced CPT1 (carnitine palmitoyltransferase 1) activity at the outer mitochondrial membrane. Recent work shows elevated ketone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4722f654bdcfca26aec6deb9d4ff33e8
https://doi.org/10.1161/circulationaha.120.052671
https://doi.org/10.1161/circulationaha.120.052671
Multiphasic triacylglycerol dynamics in the intact heart during acute in vivo overexpression of CD36
Autor:
Andrew N. Carley, Jian Bi, Xuerong Wang, Natasha H. Banke, Jason R.B. Dyck, J. Michael O'Donnell, E. Douglas Lewandowski
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 1, Pp 97-106 (2013)
Cardiac triacylglycerol (TAG) stores buffer the intracellular availability of long chain fatty acid (LCFA) that act as nuclear receptor ligands, substrate for lipotoxic derivatives, and high energy-yield fuel. The kinetic characteristics of TAG turno
Externí odkaz:
https://doaj.org/article/93403b84088b4901848010bd0bf033b2
Autor:
Euy‐Myoung Jeong, Jaehoon Chung, Hong Liu, Yeongju Go, Scott Gladstein, Afshin Farzaneh‐Far, E. Douglas Lewandowski, Samuel C. Dudley
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 5 (2016)
BackgroundDiabetes mellitus (DM) is associated with mitochondrial oxidative stress. We have shown that myocardial oxidative stress leads to diastolic dysfunction in a hypertensive mouse model. Therefore, we hypothesized that diabetes mellitus could c
Externí odkaz:
https://doaj.org/article/a030f104c67c412dba04ffc9f96778bb
Autor:
Shannon Hitchcock, Alvin D. Pewa, Eric B. Taylor, Lawrence R. Gray, Jonas Maximilian Marx, Isabelle Robillard-Frayne, Thomas Cassier, Rose McGlauflin, Fariba Tayyari, Paul V. Taufalele, Lauren Haff, Lynn M. Teesch, Jamie Soto, Peter A. Crawford, Kathy Zimmerman, Trevor Funari, Jennifer L. Stueve, Robert M. Weiss, Christine Des Rosiers, E. Douglas Lewandowski, E. Dale Abel, Yuan Zhang, James E. Cox, Adam J. Rauckhorst, Kevin D. Lin, William J. Kutschke, Patrycja Puchalska, Jared Rutter, Jesse D. Cochran, Kevin M. Kato
Publikováno v:
Nature metabolism
In addition to fatty acids, glucose and lactate are important myocardial substrates under physiologic and stress conditions. They are metabolized to pyruvate, which enters mitochondria via the mitochondrial pyruvate carrier (MPC) for citric acid cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3413162a397848a5e3eb89491638c1b3
https://doi.org/10.1038/s42255-020-00288-1
https://doi.org/10.1038/s42255-020-00288-1
Autor:
Andrew Carley, Santosh Maurya, Yang Wang, Kenneth Bedi Jr, Kenneth Margulies, E. Douglas Lewandowski
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62bf45ae2417e440429b45b340aa8377
https://doi.org/10.1016/j.yjmcc.2022.08.026
https://doi.org/10.1016/j.yjmcc.2022.08.026