Zobrazeno 1 - 10
of 831
pro vyhledávání: '"E Donahue"'
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Glioblastoma (GB) is a highly heterogeneous type of incurable brain cancer with a low survival rate. Intensive ongoing research has identified several potential targets; however, GB is marred by the activation of multiple pathways, and thus
Externí odkaz:
https://doaj.org/article/4088ce2fde8e48de96f0d471c36d2ffa
Autor:
Naoya Uchida, Ulana Stasula, Selami Demirci, Paula Germino-Watnick, Malikiya Hinds, Anh Le, Rebecca Chu, Alexander Berg, Xiong Liu, Ling Su, Xiaolin Wu, Allen E. Krouse, N. Seth Linde, Aylin Bonifacino, So Gun Hong, Cynthia E. Dunbar, Leanne Lanieri, Anjali Bhat, Rahul Palchaudhuri, Bindu Bennet, Megan Hoban, Kirk Bertelsen, Lisa M. Olson, Robert E. Donahue, John F. Tisdale
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Hematopoietic stem cell (HSC) gene therapy has curative potential; however, its use is limited by the morbidity and mortality associated with current chemotherapy-based conditioning. Targeted conditioning using antibody-drug conjugates (ADC)
Externí odkaz:
https://doaj.org/article/da5777a8fdb54d1094c35c66359052e6
Autor:
Khaled Essawi, Waleed Hakami, Muhammad Behroz Naeem Khan, Reid Martin, Jing Zeng, Rebecca Chu, Naoya Uchida, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, Gerd A. Blobel, Ulrike Gerdemann, Leslie S. Kean, Stacy A. Maitland, Scot A. Wolfe, Jean-Yves Metais, Stephen Gottschalk, Daniel E. Bauer, John F. Tisdale, Selami Demirci
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 483-493 (2023)
CRISPR-Cas9-based therapeutic genome editing approaches hold promise to cure a variety of human diseases. Recent findings demonstrate pre-existing immunity for the commonly used Cas orthologs from Streptococcus pyogenes (SpCas9) and Staphylococcus au
Externí odkaz:
https://doaj.org/article/186bb2a612c54f99a14f07e9473590ec
Autor:
Scott A. Peslak, Selami Demirci, Vemika Chandra, Byoung Ryu, Saurabh K. Bhardwaj, Jing Jiang, Jeremy W. Rupon, Robert E. Throm, Naoya Uchida, Alexis Leonard, Khaled Essawi, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, Francesca Ferrara, Matthew Wielgosz, Osheiza Abdulmalik, Nicole Hamagami, Paula Germino-Watnick, Anh Le, Rebecca Chu, Malikiya Hinds, Mitchell J. Weiss, Wei Tong, John F. Tisdale, Gerd A. Blobel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 452-465 (2023)
Transcriptional enhancers can be in physical proximity of their target genes via chromatin looping. The enhancer at the β-globin locus (locus control region [LCR]) contacts the fetal-type (HBG) and adult-type (HBB) β-globin genes during correspondi
Externí odkaz:
https://doaj.org/article/32788d42c8a3431085e1147f913baa4b
Autor:
Malcolm H. Squires, Erin E. Donahue, Michelle L. Wallander, Sally J. Trufan, Reilly E. Shea, Nicole F. Lindholm, Joshua S. Hill, Jonathan C. Salo
Publikováno v:
Current Oncology, Vol 30, Iss 2, Pp 2482-2492 (2023)
The National Surgical Quality Improvement Project (NSQIP) dataset was used to identify perioperative variables associated with the length of stay (LOS) and early discharge among cancer patients undergoing colectomy. Patients who underwent non-emergen
Externí odkaz:
https://doaj.org/article/151176e8542041fa95a3a3e98333ab2e
Autor:
Lan Wang, Gajendra W. Suryawanshi, Shihyoung Kim, Xin Guan, Aylin C. Bonifacino, Mark E. Metzger, Robert E. Donahue, Sanggu Kim, Irvin S.Y. Chen
Publikováno v:
Heliyon, Vol 9, Iss 9, Pp e19435- (2023)
Selective T-cell depletion prior to cell or organ transplantation is considered a preconditioning regimen to induce tolerance and immunosuppression. An immunotoxin consisting of a recombinant anti-CD3 antibody conjugated with diphtheria toxin was use
Externí odkaz:
https://doaj.org/article/6d1b05ec6891474793ee47b9bea7ce1b
Autor:
Owen P. Leary, Matthew Hagan, Patricia L. Zadnik Sullivan, Abigail McElroy, Sohail Syed, David D. Liu, John E. Donahue, Keith-Austin Scarfo, Alexios G. Carayannopoulos, Justin Li, Konstantina Svokos, Jared S. Fridley, Ziya L. Gokaslan, Adetokunbo A. Oyelese, Petra M. Klinge
Publikováno v:
Interdisciplinary Neurosurgery, Vol 33, Iss , Pp 101773- (2023)
Introduction: Diagnosis, pathophysiology, and rationale for surgical intervention in adult-onset tethered cord syndrome (ATCS) remain controversial. In this population, comorbid degenerative spinal disease (DSD) and prior trauma may sometimes distrac
Externí odkaz:
https://doaj.org/article/17c8b9b34c344167ac5f3f5ed4264d24
Autor:
Zainab Shahid, Alicia L. Patrick, Michelle L. Wallander, Erin E. Donahue, Sally J. Trufan, Antoinette R. Tan, Jimmy J. Hwang, Earle F. Burgess, Brittany Ragon, Nilanjan Ghosh, Michael R. Grunwald, Peter M. Voorhees, Edward A. Copelan, Derek Raghavan
Publikováno v:
Vaccine: X, Vol 14, Iss , Pp 100289- (2023)
Purpose: Cancer patients are at high risk of developing severe illness from SARS-CoV-2 infection, but risk is lowered with receipt of COVID-19 vaccine. COVID-19 vaccination uptake among previously infected cancer patients may be influenced by an assu
Externí odkaz:
https://doaj.org/article/b5e30d5ae392467681a5ca38f490956d
Autor:
Mark Willy L. Mondia, Michael A. Kritselis, John E. Donahue, Heinrich Elinzano, Sasmit Sarangi, David Bryant, Marzia Capelletti, W. Michael Korn, Esther Yu, Sherry Yan, Steven A. Toms, Eric T. Wong
Publikováno v:
Frontiers in Neurology, Vol 13 (2023)
PurposeEpithelioid glioblastoma is an unusual histologic variant of malignant glioma. The present study investigates both the genomic and transcriptomic determinants that may promote the development of this tumor.MethodsWhole-exome sequencing (WES) a
Externí odkaz:
https://doaj.org/article/e652121a3ac1494f83333864a668e459
Autor:
Sandeep K. Srivastava, Lauren L. Truitt, Chuanfeng Wu, Adam Glaser, Daniel J. Nolan, Michael Ginsberg, Diego A. Espinoza, Samson Koelle, Idalia M. Yabe, Kyung-Rok Yu, Sogun Hong, Stephanie Sellers, Allen Krouse, Aylin Bonifacino, Mark Metzger, Pradeep K. Dagur, Robert E. Donahue, Cynthia E. Dunbar, Sandhya R. Panch
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 703-715 (2021)
Ex vivo hematopoietic stem and progenitor cell (HSPC) expansion platforms are under active development, designed to increase HSPC numbers and thus engraftment ability of allogeneic cord blood grafts or autologous HSPCs for gene therapies. Murine and
Externí odkaz:
https://doaj.org/article/f752637eb89a49feb1dc785c3084f549