p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin

Autor: Aminah A. Loonat, James Clark, Katharina Tilgner, Pelin Arabacilar, Nicholas T. Hertz, Max Thomas, Michael S. Marber, Negin Sarafraz-Shekary, Kevan M. Shokat, E Denise Martin, Alma L. Burlingame, Shahzan Uddin, Rebecca S. Levin

Publikováno v: Loonat, A A, Martin, E D, Sarafraz-Shekary, N, Tilgner, K, Hertz, N T, Levin, R, Shokat, K M, Burlingame, A L, Arabacilar, P, Uddin, S, Thomas, M, Marber, M S & Clark, J E 2019, ' p38γ MAPK contributes to left ventricular remodeling after pathologic stress and disinhibits calpain through phosphorylation of calpastatin ', Faseb Journal, vol. 33, no. 12, pp. 13131-13144 . https://doi.org/10.1096/fj.201701545R

Despite the high and preferential expression of p38γ MAPK in the myocardium, little is known about its function in the heart. The aim of the current study was to elucidate the physiologic and biochemical roles of p38γ in the heart. Expression and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6495c6e9f2f2092f9b7c4ede0c6d39e
https://kclpure.kcl.ac.uk/ws/files/123773029/fj.201701545r.pdf

ELUCIDATING THE ROLE OF P38γ IN PATHOLOGICAL CARDIAC HYPERTROPHY

Autor: Francesca Hunt, Sang Hoon Choi, Kevan M. Shokat, Michael S. Marber, Aminah A. Loonat, E Denise Martin, Alma L. Burlingame, Becca Levin, James Clark, Nicholas T. Hertz

Publikováno v: Heart. 100:A18.2-A18

P38-mitogen activated protein kinases (of which there are 4 isoforms; α, β, γ and δ) are serine/threonine kinases that are activated in response to stress stimuli. Classically studies have only examined the role of p38α in the myocardium. Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::900c215c418f36793b5429e1dc37fee8
https://doi.org/10.1136/heartjnl-2014-306916.54