Zobrazeno 1 - 10 of 24 pro vyhledávání: '"E D, Mihelich"'
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Recombinant human secretory phospholipase A2 released thromboxane from guinea pig bronchoalveolar lavage cells: in vitro and ex vivo evaluation of a novel secretory phospholipase A2 inhibitor
Autor: J H, Fleisch, C T, Armstrong, C R, Roman, E D, Mihelich, S M, Spaethe, W T, Jackson, J L, Bobbitt, S, Draheim, N J, Bach, R D, Dillard, M, Martinelli, R, Fouts, D W, Snyder
Publikováno v: The Journal of pharmacology and experimental therapeutics. 278(1)
The primary objective of this study was to develop a functional assay that could provide rapid and reliable information on some pharmacologic characteristics of a novel inhibitor of human secretory phospholipase A2 (sPLA2). Guinea pig bronchoalveolar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b017882cc52f03933a8bb54ca8786e7e
https://pubmed.ncbi.nlm.nih.gov/8764358
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3
Characterization of the contractile effects of human recombinant nonpancreatic secretory phospholipase A2 (PLA2) and other PLA2s on guinea pig lung pleural strips
Autor: D W, Snyder, C D, Sommers, J L, Bobbitt, E D, Mihelich
Publikováno v: The Journal of pharmacology and experimental therapeutics. 266(3)
Contractile activities of nPLA2, pPLA2 and hPLA2 were characterized on pleural strips of guinea pig lung. The rank order of potency for these PLA2s was nPLA2pPLA2hPLA2. The concentration-related contractions induced by nPLA2 (0.0002-0.67 micrograms/m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3a2efd641180e7798c91f4d6f6c3749
https://pubmed.ncbi.nlm.nih.gov/8371132
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4
Evidence that phospholipase A2 (PLA2) inhibitors can selectively block PLA2-mediated contractions of guinea pig lung pleural strips
Autor: D W, Snyder, C D, Sommers, J L, Bobbitt, E D, Mihelich
Publikováno v: The Journal of pharmacology and experimental therapeutics. 262(3)
We have demonstrated previously that porcine pancreatic phospholipase A2 (PLA2)-induced contractions of guinea pig lung pleural strips can be abated by inhibitors of cyclooxygenase and 5-lipoxygenase pathways, suggesting the liberation of arachidonic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8138ab6dcb955b506b4662ac8f6fc496
https://pubmed.ncbi.nlm.nih.gov/1527719
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5
Inhibition of venom phospholipases A2 by manoalide and manoalogue. Stoichiometry of incorporation
Autor: L J, Reynolds, E D, Mihelich, E A, Dennis
Publikováno v: The Journal of biological chemistry. 266(25)
We have previously described the irreversible inhibition of cobra venom phospholipase A2 (PLA2) by the marine natural product manoalide (MLD) (Lombardo, D., and Dennis, E. A. (1985) J. Biol. Chem. 260, 7234-7240) and by its synthetic analog, manoalog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef51beb24df513a70d0946e83242ee8a
https://pubmed.ncbi.nlm.nih.gov/1885583
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6
Inhibition of venom phospholipases A2 by manoalide and manoalogue. Stoichiometry of incorporation
Autor: E. D. Mihelich, Edward A. Dennis, Laure J. Reynolds
Publikováno v: The Journal of biological chemistry, vol 266, iss 25
Scopus-Elsevier
We have previously described the irreversible inhibition of cobra venom phospholipase A2 (PLA2) by the marine natural product manoalide (MLD) (Lombardo, D., and Dennis, E. A. (1985) J. Biol. Chem. 260, 7234-7240) and by its synthetic analog, manoalog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d034bc6c5d6dd41f5d2f8520a4ef2e
https://escholarship.org/uc/item/1v72p3gs
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7
Characterization of LY233569 on 5-lipoxygenase and reperfusion injury of ischemic myocardium
Autor: R A, Hahn, B R, MacDonald, P J, Simpson, L, Wang, R D, Towner, P P, Ho, M, Goodwin, A P, Breau, T, Suarez, E D, Mihelich
Publikováno v: The Journal of pharmacology and experimental therapeutics. 256(1)
LY233569 produced concentration-dependent inhibition of isolated guinea pig 5-lipoxygenase (5-LPO) and 5-LPO activity of human polymorphonuclear leukocytes in vitro; IC50 values were 0.4 and 0.1 microM, respectively. LY233569 also inhibited (IC50 app
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b33d3369ce663eb83780f5da4beb4ce
https://pubmed.ncbi.nlm.nih.gov/1988671
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