Zobrazeno 1 - 10
of 39
pro vyhledávání: '"E D, Kharasch"'
Publikováno v:
Acta anaesthesiologica Scandinavica. 47(6)
Cytochrome P4502E1(CYP2E1)-mediated oxidation of halothane to a reactive intermediate (trifluoroacyl chloride) that covalently binds to hepatic proteins forming trifluoroacetylated neoantigens is believed to be the initiating event in a complex immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c99d6bf0e235051425dcdc35c838358
https://pubmed.ncbi.nlm.nih.gov/12803597
https://pubmed.ncbi.nlm.nih.gov/12803597
Publikováno v:
Acta anaesthesiologica Scandinavica. 47(3)
The gender aspect in pharmacokinetics and pharmacodynamics of anesthetics has attracted little attention. Knowledge of previous work is required to decide if gender-based differences in clinical practice is justified, and to determine the need for re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23b850a823aa1c633991193da4d67008
https://pubmed.ncbi.nlm.nih.gov/12648189
https://pubmed.ncbi.nlm.nih.gov/12648189
Publikováno v:
Acta anaesthesiologica Scandinavica. 46(7)
Nasal administration of opioids may be an alternative route to intravenous, subcutaneous, oral transmucosal, oral or rectal administration in some patients. Key features may be self-administration, combined with rapid onset of action. The aim of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e093eaf6302012932cf3c31041162b1c
https://pubmed.ncbi.nlm.nih.gov/12139528
https://pubmed.ncbi.nlm.nih.gov/12139528
Autor:
S, Phimmasone, E D, Kharasch
Publikováno v:
Clinical pharmacology and therapeutics. 70(6)
The opioid alfentanil is a CYP3A4 substrate whose plasma clearance depends exclusively on hepatic CYP3A4 activity. Alfentanil clearance is an excellent in vivo probe for hepatic CYP3A4 activity and drug interactions in humans. However, such pharmacok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0305222cf4d4e737ad1008d55a3cde27
https://pubmed.ncbi.nlm.nih.gov/11753266
https://pubmed.ncbi.nlm.nih.gov/11753266
Autor:
Y, Oda, E D, Kharasch
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 298(3)
Methadone and levo-alpha-acetylmethadol (LAAM) are opioid agonists used for analgesia and preventing opiate withdrawal. Methadone is sequentially N-demethylated to the inactive metabolites 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a1d62fa0a7861cd217f5b5a23f66b2e
https://pubmed.ncbi.nlm.nih.gov/11504799
https://pubmed.ncbi.nlm.nih.gov/11504799
Autor:
Y, Oda, E D, Kharasch
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 297(1)
levo-alpha-Acetylmethadol (LAAM) is a long-acting opioid agonist prodrug used for preventing opiate withdrawal. LAAM undergoes bioactivation via sequential N-demethylation to nor-LAAM and dinor-LAAM, which are more potent and longer-acting than LAAM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9cc2ce336fefc1b1c8df8e00506c453a
https://pubmed.ncbi.nlm.nih.gov/11259570
https://pubmed.ncbi.nlm.nih.gov/11259570
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(1)
Methoxsalen (8-methoxypsoralen) is an effective and selective mechanism-based inhibitor of human hepatic cytochrome P-450 (CYP)2A6 in vitro, and may have utility as a clinical probe for CYP2A6-catalyzed xenobiotic metabolism in humans in vivo. This i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5bb39875b92827aca7dad3477f750303
https://pubmed.ncbi.nlm.nih.gov/10611136
https://pubmed.ncbi.nlm.nih.gov/10611136
Autor:
E D, Kharasch, C, Jubert
Publikováno v:
Anesthesiology. 91(5)
Sevoflurane is degraded during low-flow anesthesia to fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A"), which causes renal necrosis in rats but is not known to cause nephrotoxicity in surgical patients. Compound A is metabolize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2e2e5a2d366a578910f2e30c9f2c085
https://pubmed.ncbi.nlm.nih.gov/10551576
https://pubmed.ncbi.nlm.nih.gov/10551576
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 291(1)
Disulfiram (DSF) is a mechanism-based inhibitor of cytochrome P-450 2E1 (CYP2E1), resulting in loss of CYP2E1 protein and activity, which may be useful in preventing CYP2E1-mediated xenobiotic toxicity. The duration of inhibition after a single DSF d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33e9bce14a1672422cd2d4b0b9b92673
https://pubmed.ncbi.nlm.nih.gov/10490907
https://pubmed.ncbi.nlm.nih.gov/10490907
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(6)
Disulfiram and its primary metabolite diethyldithiocarbamate are effective mechanism-based inhibitors of cytochrome P-450 2E1 (CYP2E1)1 in vitro. Single-dose disulfiram diminishes CYP2E1 activity in vivo and has been used to identify CYP2E1 participa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::158d3f8e69939368fa8c6b8a645de365
https://pubmed.ncbi.nlm.nih.gov/10348802
https://pubmed.ncbi.nlm.nih.gov/10348802