MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies

Autor: G S Choudhary, S Al-harbi, S Mazumder, B T Hill, M R Smith, J Bodo, E D Hsi, A Almasan

Publikováno v: Cell Death and Disease, Vol 6, Iss 1, Pp e1593-e1593 (2015)

Abstract Overexpression of anti-apoptotic BCL-2 family members is a hallmark of many lymphoid malignancies, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL) that can be targeted with small molecule inhibitors. ABT-199 is a

Externí odkaz: https://doaj.org/article/01ff4a6ad1a9402280aa58f1947766a7

Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study

Autor: C Visco, Y Li, Z Y Xu-Monette, R N Miranda, T M Green, A Tzankov, W Wen, W-m Liu, B S Kahl, E S G d'Amore, S Montes-Moreno, K Dybkær, A Chiu, W Tam, A Orazi, Y Zu, G Bhagat, J N Winter, H-Y Wang, S O'Neill, C H Dunphy, E D Hsi, X F Zhao, R S Go, W W L Choi, F Zhou, M Czader, J Tong, X Zhao, J H van Krieken, Q Huang, W Ai, J Etzell, M Ponzoni, A J M Ferreri, M A Piris, M B Møller, C E Bueso-Ramos, L J Medeiros, L Wu, K H Young

Publikováno v: Leukemia, 26, 2103-2113
Visco, C, Li, Y, Xu-Monette, Z Y, Miranda, R N, Green, T M, Li, Y, Tzankov, A, Wen, W, Liu, W, Kahl, B S, d'Amore, E S G, Montes-Moreno, S, Dybkær, K, Chiu, A, Tam, W, Orazi, A, Zu, Y, Bhagat, G, Winter, J N, Wang, H-Y, O'Neill, S, Dunphy, C H, Hsi, E D, Zhao, X F, Go, R S, Choi, W W L, Zhou, F, Czader, M, Tong, J, Zhao, X, van Krieken, J H, Huang, Q, Ai, W, Etzell, J, Ponzoni, M, Ferreri, A J M, Piris, M A, Møller, M B, Bueso-Ramos, C E, Medeiros, L J, Wu, L & Young, K H 2012, ' Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma : a report from the International DLBCL Rituximab-CHOP Consortium Program Study ', Leukemia, vol. 26, no. 9, pp. 2103-2113 . https://doi.org/10.1038/leu.2012.83
Leukemia, 26, 9, pp. 2103-2113
Visco, C, Li, Y, Xu-Monette, Z Y, Miranda, R N, Green, T M, Li, Y, Tzankov, A, Wen, W, Liu, W-M, Kahl, B S, d'Amore, E S G, Montes-Moreno, S, Dybkær, K, Chiu, A, Tam, W, Orazi, A, Zu, Y, Bhagat, G, Winter, J N, Wang, H-Y, O'Neill, S, Dunphy, C H, Hsi, E D, Zhao, X F, Go, R S, Choi, W W L, Zhou, F, Czader, M, Tong, J, Zhao, X, van Krieken, J H, Huang, Q, Ai, W, Etzell, J, Ponzoni, M, Ferreri, A J M, Piris, M A, Møller, M B, Bueso-Ramos, C E, Medeiros, L J, Wu, L & Young, K H 2012, ' Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma : A report from the International DLBCL Rituximab-CHOP consortium program study ', Leukemia, vol. 26, no. 9, pp. 2103-13 . https://doi.org/10.1038/leu.2012.83

Gene expression profiling (GEP) has stratified diffuse large B-cell lymphoma (DLBCL) into molecular subgroups that correspond to different stages of lymphocyte development-namely germinal center B-cell-like and activated B-cell-like. This classificat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897a8e1b50bbc3f018dfbbfafbea6327
http://hdl.handle.net/2066/110658

Erratum: Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study

Autor: C Visco, Y Li, Z Y Xu-Monette, R N Miranda, T M Green, A Tzankov, W Wen, W-m Liu, B S Kahl, E S G d'Amore, S Montes-Moreno, K Dybkær, A Chiu, W Tam, A Orazi, Y Zu, G Bhagat, J N Winter, H-Y Wang, S O'Neill, C H Dunphy, E D Hsi, X F Zhao, R S Go, W W L Choi, F Zhou, M Czader, J Tong, X Zhao, J H van Krieken, Q Huang, W Ai, J Etzell, M Ponzoni, A J M Ferreri, M A Piris, M B Møller, C E Bueso-Ramos, L J Medeiros, L Wu, K H Young

Publikováno v: Leukemia. 28:980-980

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce49f8ccd2c1781cf7eaf9eb6f850cfd
https://doi.org/10.1038/leu.2014.24

Mechanisms of apoptosis in T cells from patients with renal cell carcinoma

Autor: R G, Uzzo, P, Rayman, V, Kolenko, P E, Clark, T, Bloom, A M, Ward, L, Molto, C, Tannenbaum, L J, Worford, R, Bukowski, R, Tubbs, E D, Hsi, N H, Bander, A C, Novick, J H, Finke

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(5)

Tumors may escape immune recognition and destruction through the induction of apoptosis in activated T lymphocytes. Results from several laboratories suggest that FasL (L/CD95L) expression in tumors may be responsible for this process. In this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f09ebf5ea645ca5357c7828c9318e2c
https://pubmed.ncbi.nlm.nih.gov/10353760

Usefulness of an immunohistochemical panel in paraffin-embedded tissues for the differentiation of B-cell non-Hodgkin's lymphomas of small lymphocytes

Autor: E D, de Leon, S, Alkan, J C, Huang, E D, Hsi

Publikováno v: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 11(11)

Diagnosis of small B-cell lymphomas is sometimes difficult without fresh tissue for flow cytometry (FC) or immunohistochemistry (IHC). Therefore, we examined the usefulness of a paraffin section IHC panel consisting of antibodies to CD5, CD10, CD20,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::685d3dbfb2e5433dbc08b066d28b801f
https://pubmed.ncbi.nlm.nih.gov/9831200