Zobrazeno 1 - 7
of 7
pro vyhledávání: '"E D, Bischoff"'
Publikováno v:
Cancer research. 60(21)
Targretin (LGD1069; a high-affinity ligand for the retinoid X receptors) is an efficacious chemotherapeutic and chemopreventive agent in the N-nitroso-N-methylurea-induced rat mammary carcinoma model. To evaluate the molecular action of LGD1069 in ma
Autor:
S D, Gamage, E D, Bischoff, K D, Burroughs, W W, Lamph, M M, Gottardis, C L, Walker, R, Fuchs-Young
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 295(2)
The conventional treatment of uterine leiomyomas, or fibroids, with gonadotropin-releasing hormone (GnRH) agonists is often associated with serious side effects, necessitating short-term, palliative use of this therapy. Therefore, we examined a retin
Publikováno v:
Cancer research. 58(3)
Recently, we reported that LGD1069, a high-affinity ligand for the retinoid X receptors (RXRs), was shown to have an efficacy equivalent to that of tamoxifen (TAM) as a chemopreventive agent in the N-nitroso-N-methylurea-induced rat mammary carcinoma
Autor:
D R, Shalinsky, E D, Bischoff, W W, Lamph, L, Zhang, M F, Boehm, P J, Davies, A M, Nadzan, R A, Heyman
Publikováno v:
Cancer research. 57(1)
We have identified a novel retinoid, ALRT1550, that potently and selectively activates retinoic acid receptors (RARs). ALRT1550 binds RARs with Kd values of approximately equal to 1-4 nM, and retinoid X receptors with low affinities (Kd approximately
Publikováno v:
Cancer research. 56(24)
Recently, 9-cis retinoic acid, a high affinity ligand for retinoic acid receptors and retinoid X-receptors (RXRs), was shown to have efficacy superior to all-trans retinoic acid as a chemopreventive agent in the N-nitroso-N-methylurea-induced rat mam
Autor:
D R, Shalinsky, E D, Bischoff, M L, Gregory, W W, Lamph, R A, Heyman, J S, Hayes, V, Thomazy, P J, Davies
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(3)
Cisplatin (DDP) is commonly used to treat head and neck tumors. Therapy frequently fails due to development of DDP resistance or toxicities associated with DDP therapy. In this study, effects of ALRT1057 [9-cis retinoic acid (9-cis RA)] on DDP cytoto
Autor:
D R, Shalinsky, E D, Bischoff, M L, Gregory, M M, Gottardis, J S, Hayes, W W, Lamph, R A, Heyman, M A, Shirley, T A, Cooke, P J, Davies
Publikováno v:
Cancer research. 55(14)
Retinoids are promising agents for therapy of squamous cancers. In vitro, retinoids decrease expression of differentiation markers in head and neck squamous carcinoma cells. Little information is available on effects of retinoids on head and neck squ