Zobrazeno 1 - 3
of 3
pro vyhledávání: '"E C Vanzela"'
Autor:
Diane Delaroche, E C Vanzela, Fernanda Ortis, Henrik B. Mortensen, Lotte B Nielsen, Alessandra K Cardozo, Joachim Størling, Geert van Loo, Leen Catrysse, Makiko Fukaya, Rudi Beyaert, Flemming Pociot, Marie Louise Max M.L. Andersen, Caroline Brorsson, Kira Meyerovich
Publikováno v:
Molecular Endocrinology. 30:48-61
Activation of the transcription factor nuclear factor kappa B (NFkB) contributes to β-cell death in type 1 diabetes (T1D). Genome-wide association studies have identified the gene TNF-induced protein 3 (TNFAIP3), encoding for the zinc finger protein
Autor:
E C Vanzela, Alessandra K Cardozo
Publikováno v:
Diabetologia. 55:1572-1576
Type 1 diabetes is a chronic autoimmune disease involving the progressive loss of beta cell mass. Cytokines released by immune cells are early contributors to beta cell apoptosis. Thus, an understanding of the signal transduction mechanisms induced b