C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation

Autor: B.A. van der Reijden, Joost H.A. Martens, Nilofar Sharifi, Hendrik G. Stunnenberg, Eva M. Janssen-Megens, Joop H. Jansen, Christian M. Zwaan, Saskia M. Bergevoet, Bowon Kim, Mathijs A. Sanders, J Knijnenburg, Anna E. Marneth, Peter J. M. Valk, Maarten Fornerod, A. S. Al Hinai, T C J M Arentsen-Peters, Torsten Haferlach, Jorren Kuster, E C G Stoetman, Marie-Laure Yaspo, Niccolò Tesi, M M van den Heuvel-Eibrink, Koen H.M. Prange

Publikováno v: Leukemia : the Journal of Normal and Malignant Hemopoiese ; Official Journal of the Leukemia Research Fund U.K.
Leukemia, 32(3), 828-836. Nature Publishing Group
Leukemia, 32, pp. 828-836
Leukemia, 32, 828-836. Macmillan Publishers Limited, part of Springer Nature.
Leukemia, 32(3), 828-836

Overexpression of the BRE (brain and reproductive organ-expressed) gene defines a distinct pediatric and adult acute myeloid leukemia (AML) subgroup. Here we identify a promoter enriched for active chromatin marks in BRE intron 4 causing strong biall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0991d6d688f32e57394edc14b63b95c
https://doi.org/10.1038/leu.2017.280