The role of P-glycoprotein in blood-brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice

Autor: R, Xie, M, Hammarlund-Udenaes, A G, de Boer, E C, de Lange

Publikováno v: British journal of pharmacology. 128(3)

1. The aim of this study was to investigate whether blood-brain barrier transport of morphine was affected by the absence of mdr1a-encoded P-glycoprotein (Pgp), by comparing mdr1a (-/-) mice with mdr1a (+/+) mice. 2. Mdr1a (-/-) and (+/+) mice receiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1595e130f2700cb38d1f296cf8d4cbb3
https://pubmed.ncbi.nlm.nih.gov/10516633

Drug equilibration across the blood-brain barrier--pharmacokinetic considerations based on the microdialysis method

Autor: M, Hammarlund-Udenaes, L K, Paalzow, E C, de Lange

Publikováno v: Pharmaceutical research. 14(2)

The purpose of the study was to investigate the influence of different rates of transport into and out of the brain, including passive and active transport, on unbound brain concentrations and profile in relation to the blood concentration profile. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::291148347ed63f6514a3e4b39252ec54
https://pubmed.ncbi.nlm.nih.gov/9090698

The use of intracerebral microdialysis to determine changes in blood-brain barrier transport characteristics

Autor: E C, de Lange, M B, Hesselink, M, Danhof, A G, de Boer, D D, Breimer

Publikováno v: Pharmaceutical research. 12(1)

The aim of this study was to determine whether changes in the transport of drugs into the brain could be determined by in vivo intracerebral microdialysis. Atenolol was used as a model drug to determine blood-brain barrier (BBB) transport characteris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1de6ab7d7c6f63e972b63bd00c6e0682
https://pubmed.ncbi.nlm.nih.gov/7724474

Recent Progress on Biosensors for the Early Detection of Neurological Disorders.

Autor: Chougale, Amit¹ (AUTHOR) amit.chougale@adelaide.edu.au, Vedante, Shruti¹ (AUTHOR), Kulkarni, Guruprasad² (AUTHOR), Patnawar, Sneha³ (AUTHOR)

Publikováno v: ChemistrySelect. 12/6/2022, Vol. 7 Issue 45, p1-16. 16p.

Accurate Spatial Heterogeneity Dissection and Gene Regulation Interpretation for Spatial Transcriptomics using Dual Graph Contrastive Learning.

Autor: Yu Z; School of Artificial Intelligence, Jilin University, Jilin, 130012, China., Yang Y; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada., Chen X; Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02115, USA., Wong KC; Department of Computer Science, City University of Hong Kong, Hong Kong, SAR, 999077, Hong Kong., Zhang Z; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada., Zhao Y; College of Computer and Control Engineering, Northeast Forestry University, Harbin, 150040, China., Li X; School of Artificial Intelligence, Jilin University, Jilin, 130012, China.; Department of Computer Science, City University of Hong Kong, Hong Kong, SAR, 999077, Hong Kong.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Nov 28, pp. e2410081. Date of Electronic Publication: 2024 Nov 28.