Výsledky vyhledávání

A mutation in the alpha subunit of the platelet integrin alphaIIbbeta3 identifies a novel region important for ligand binding

Autor: E C, Tozer, E K, Baker, M H, Ginsberg, J C, Loftus

Publikováno v: Blood. 93(3)

An unbiased genetic approach was used to identify a specific amino acid residue in the alphaIIb subunit important for the ligand binding function of the integrin alphaIIbbeta. Chemically mutagenized cells were selected by flow cytometry based on thei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ba0bbd2e3d59207c32208ed27f3f3d4
https://pubmed.ncbi.nlm.nih.gov/9920841

Zobrazit plný text záznamu

Ligand binding to integrin alphaIIbbeta3 is dependent on a MIDAS-like domain in the beta3 subunit

Autor: E C, Tozer, R C, Liddington, M J, Sutcliffe, A H, Smeeton, J C, Loftus

Publikováno v: The Journal of biological chemistry. 271(36)

Substitution of beta3 residue Asp119, Ser121, or Ser123 results in a loss of the ligand binding function of integrin alphaIIbbeta3. Homologous residues in other integrin beta subunits are similarly critical for ligand binding function. This DXSXS mot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d838b4600db6b3e05d04df1b0543738
https://pubmed.ncbi.nlm.nih.gov/8703003

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání