Výsledky vyhledávání - "E C, Maduakor"

ChemInform Abstract: Fluorine as an ortho-Directing Group in Aromatic Metalation: A Two Step Preparation of Substituted Benzo(b)thiophene-2-carboxylates

Autor: Alexander J. Bridges, Arthur Lee, C. E. Schwartz, E. C. Maduakor

Publikováno v: ChemInform. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3589ca8986e4a5ace96088bf06b54ad0
https://doi.org/10.1002/chin.199317151

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ChemInform Abstract: Fluorine as an ortho-Directing Group in Aromatic Metalation: Generality of the Reaction and the High Position of Fluorine in the Dir-Met (Directed Metalation) Potency Scale

Autor: C. E. Schwartz, Arthur Lee, E. C. Maduakor, Alexander J. Bridges

Publikováno v: ChemInform. 24

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6be099eea686e3d8da28734765f0bffb
https://doi.org/10.1002/chin.199317124

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Fluorine as an ortho-directing group in aromatic metalation: A two step preparation of substituted benzo[b]thiophene-2-carboxylates

Autor: C.Eric Schwartz, E. C. Maduakor, Arthur Lee, Alexander J. Bridges

Publikováno v: Tetrahedron Letters. 33:7499-7502

A simple 2-step synthesis of B-ring substituted benzo[b]thiophene-2-carboxylates from aryl fluorides has been developed. The route involves a selective lithiation ortho to fluorine, followed by formylation, and subsequently, displacement of fluorine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aad673901c53321bab44ad22c4d1b135
https://doi.org/10.1016/s0040-4039(00)60806-7

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Fluorine as an ortho-directing group in aromatic metalation: Generality of the reaction and the high position of fluorine in the Dir-Met potency scale

Autor: C.Eric Schwartz, Arthur Lee, Alexander J. Bridges, E. C. Maduakor

Publikováno v: Tetrahedron Letters. 33:7495-7498

Many para-substituted fluorobenzenes can be lithiated ortho to fluorine in moderate to good yields, often with one of the dialkylamide bases, lithium diisopropylamide (LDA) or lithium 2,2,6,6-tetramethylpiperidide (LiTMP). Intramolecular competition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfc4fae264b18f7d12c254849ff44327
https://doi.org/10.1016/s0040-4039(00)60805-5

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Inhibition of urokinase by 4-substituted benzo[b]thiophene-2-carboxamidines: an important new class of selective synthetic urokinase inhibitor

Autor: M J, Towle, A, Lee, E C, Maduakor, C E, Schwartz, A J, Bridges, B A, Littlefield

Publikováno v: Cancer research. 53(11)

Urokinase-type plasminogen activator (uPA) is an important mediator of cellular invasiveness. Specifically, cell surface receptor-bound uPA activates plasminogen to the potent general protease plasmin, which then degrades extracellular matrix or base

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f45cf27b27829cb884c7d9b888edd22
https://pubmed.ncbi.nlm.nih.gov/8495419

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