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Nucleotide sequence of rat haptoglobin cDNA. Characterization of the alpha beta-subunit junction region of prohaptoglobin

Autor: E C Heath, L A Goldstein

Publikováno v: Journal of Biological Chemistry. 259:9212-9217

The biosynthesis of rat haptoglobin, a hetrotetrameric glycoprotein (alpha 2 beta 2), requires the post-translational cleavage of its glycosylated primary translation product (prohaptoglobin) into alpha- and beta-subunits (Hanley, J. M., Haugen, T. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfacb44a4da132305dff6f7acfaeb70d
https://doi.org/10.1016/s0021-9258(17)47287-5

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A hybrid protein containing the toxic subunit of ricin and the cell-specific subunit of human chorionic gonadotropin. II. Biologic properties

Autor: T N Oeltmann, E C Heath

Publikováno v: Journal of Biological Chemistry. 254:1028-1032

The biologic properties of a purified hybrid protein containing the toxic subunit A of ricin and the cell-specific subunit of human chorionic gonadotropin (hCGbeta) in a disulfide conjugate is reported. The biologic activity of the hybrid has been st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac0b8a780d859e542f513c58fdeb132e
https://doi.org/10.1016/s0021-9258(17)34162-5

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A hybrid protein containing the toxic subunit of ricin and the cell-specific subunit of human chorionic gonadotropin. I. Synthesis and characterization

Autor: E C Heath, T N Oeltmann

Publikováno v: Journal of Biological Chemistry. 254:1022-1027

In order to study the mechanisms involved in the interaction of cell-surface components and effector proteins, we synthesized a double-labeled dimeric hybrid molecule consisting of the toxic A subunit of the lectin ricin and the cell-specific beta su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b61926a1b00258559743cd3bfa64514
https://doi.org/10.1016/s0021-9258(17)34161-3

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Biosynthesis, processing, and secretion of M and Z variant human alpha 1-antitrypsin

Autor: Kathryn M. Verbanac, E C Heath

Publikováno v: Journal of Biological Chemistry. 261:9979-9989

The Z genetic variant of human alpha 1-antitrypsin (alpha 1AT) is associated with decreased serum alpha 1AT levels, hepatic inclusion bodies, and an increased risk of lung and liver disease. We studied the biosynthesis, processing, and secretion of n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7990b7384d4f7c37faab9c6a13111781
https://doi.org/10.1016/s0021-9258(18)67612-4

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Relative and Absolute Bioavailability of Prednisone and Prednisolone After Separate Oral and Intravenous Doses

Autor: A. M. Horvath, Ihor Bekersky, C. F. Ryan, J. J. Ferry, E. C. Heath, Wayne A. Colburn

Publikováno v: The Journal of Clinical Pharmacology. 28:81-87

A randomized, four-way cross-over study was conducted in eight healthy male volunteers to determine the relative and absolute bioavailability of prednisone (PN) and prednisolone (PL). PN and PL were administered as single, oral 10-mg tablet doses and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499b1294632b6b3f6dcb2d9ed34ea920
https://doi.org/10.1002/j.1552-4604.1988.tb03105.x

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Glycoprotein biosynthesis in myeloma cells. Characterization on nonglycosylated immunoglobulin light chain secreted in presence of 2-deoxy-D-glucose

Autor: E C Heath, P K Eagon

Publikováno v: Journal of Biological Chemistry. 252:2372-2383

The biosynthesis and secretion of a glycosylated, K-type immunoglobulin light chain (K-46) was studied in a mouse myeloma tumor, mineral oil plasmacytoma-46B. Viable single cell suspensions were prepared from excised tumors and optimal conditions wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77300c1e0251088a89a0e217e42e87f9
https://doi.org/10.1016/s0021-9258(17)40564-3

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The relationship between rat major acute phase protein and the kininogens

Autor: K P Anderson, E C Heath

Publikováno v: Journal of Biological Chemistry. 260:12065-12071

The rat major acute phase protein (alpha 1-MAP) is a cysteine protease inhibitor. The stoichiometry of the interaction between the inhibitor and enzyme was shown to be 1:2. A cDNA clone specific for rat alpha 1-MAP was isolated from a cDNA library pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::745d4700f2bf083b127a1ed80a8ca767
https://doi.org/10.1016/s0021-9258(17)38986-x

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