Zobrazeno 1 - 9
of 9
pro vyhledávání: '"E C, Gurley"'
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 12, Pp 2446-2454 (1997)
The feedback repression of cholesterol 7alpha-hydroxylase transcriptional activity and mRNA levels by taurocholate (TCA) occurs via a protein kinase C (PKC)-dependent signal. To determine whether bile acids could activate PKC indirectly via generatio
Externí odkaz:
https://doaj.org/article/834e6267283645e9871a33373a71f4bd
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 6, Pp 1359-1369 (1995)
Inhibitors of protein kinases were screened for the ability to prevent the repression of cholesterol 7 alpha-hydroxylase mRNA by taurocholate in primary cultures of adult rat hepatocytes. The addition of taurocholate (25 microM) for 6 h decreased cho
Externí odkaz:
https://doaj.org/article/7744bbdcc70544dfb899534631550d8d
Publikováno v:
Journal of lipid research. 38(12)
The feedback repression of cholesterol 7alpha-hydroxylase transcriptional activity and mRNA levels by taurocholate (TCA) occurs via a protein kinase C (PKC)-dependent signal. To determine whether bile acids could activate PKC indirectly via generatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04fd586c022e4c6372c5bfd0402ee137
https://pubmed.ncbi.nlm.nih.gov/9458268
https://pubmed.ncbi.nlm.nih.gov/9458268
Publikováno v:
Journal of lipid research. 36(6)
The importance of cholesterol and "oxysterols" in the regulation of cholesterol 7 alpha-hydroxylase is not clear. Previous in vivo studies suggest that cholesterol may up-regulate cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce7328ae69bb1eb7f4d888ac302c478e
https://pubmed.ncbi.nlm.nih.gov/7665995
https://pubmed.ncbi.nlm.nih.gov/7665995
Autor:
P B, Hylemon, E C, Gurley, R T, Stravitz, J S, Litz, W M, Pandak, J Y, Chiang, Z R, Vlahcevic
Publikováno v:
The Journal of biological chemistry. 267(24)
In primary cultures of adult rat hepatocytes the level of cholesterol 7 alpha-hydroxylase steady-state mRNA markedly decreased by 72 h. However, the addition of L-thyroxine (T4) and dexamethasone synergistically returned cholesterol 7 alpha-hydroxyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::989a1036efa8fdb78a7d0bfbd0d1744a
https://pubmed.ncbi.nlm.nih.gov/1512229
https://pubmed.ncbi.nlm.nih.gov/1512229
Autor:
P F, Duckworth, Z R, Vlahcevic, E J, Studer, E C, Gurley, D M, Heuman, Z H, Beg, P B, Hylemon
Publikováno v:
The Journal of biological chemistry. 266(15)
We have previously reported that relatively hydrophobic bile acids, decreased hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase (reductase) activity whereas, hydrophilic bile acids had little effect on the enzyme. The purpose of the present stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd10cbcf007740b3023779edb3ef88b0
https://pubmed.ncbi.nlm.nih.gov/2033042
https://pubmed.ncbi.nlm.nih.gov/2033042
Autor:
W M, Pandak, Y C, Li, J Y, Chiang, E J, Studer, E C, Gurley, D M, Heuman, Z R, Vlahcevic, P B, Hylemon
Publikováno v:
The Journal of biological chemistry. 266(6)
Cholesterol 7 alpha-hydroxylase catalyzes the rate-limiting step in the bile acid biosynthetic pathway. Regulation of this pathway is thought to occur solely as a result of a negative feedback control mechanism that is dependent upon the flux and com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08c84493109ac2116087ab490c8d61c8
https://pubmed.ncbi.nlm.nih.gov/1995604
https://pubmed.ncbi.nlm.nih.gov/1995604
Publikováno v:
The Journal of biological chemistry. 260(25)
The effect of individual bile acids on bile acid synthesis was studied in primary hepatocyte cultures. Relative rates of bile acid synthesis were measured as the conversion of lipoprotein [4-14C]cholesterol into 4-14C-labeled bile acids. Additions to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a2a9cffae2ae206aa9ef53c04182d91
https://pubmed.ncbi.nlm.nih.gov/4055743
https://pubmed.ncbi.nlm.nih.gov/4055743
Publikováno v:
The Journal of biological chemistry. 260(2)
Monolayer cultures of hepatocytes isolated from cholestyramine-fed rats and incubated in serum-free medium converted exogenous [4-14C]cholesterol into bile acids at a 3-fold greater rate than did cultures of hepatocytes prepared from untreated rats.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::517671fd5dba73384773a21e08d26797
https://pubmed.ncbi.nlm.nih.gov/3968056
https://pubmed.ncbi.nlm.nih.gov/3968056