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Human papillomavirus type 16 E6 inactivation of p53 in normal human mammary epithelial cells promotes tamoxifen-mediated apoptosis

Autor: V L, Seewaldt, K, Mrózek, E C, Dietze, M, Parker, L E, Caldwell

Publikováno v: Cancer research. 61(2)

Aberrant p53 expression is frequently observed in mammary epithelial cells obtained from women at high risk for developing breast cancer and is a predictor for the subsequent development of malignancy. Tamoxifen has recently been shown to reduce the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a1555d547954d8ef31c102d388144adb
https://pubmed.ncbi.nlm.nih.gov/11212259

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Localization of the C-terminus of rat glutathione S-transferase A1-1: crystal structure of mutants W21F and W21F/F220Y

Autor: E T, Adman, I, Le Trong, R E, Stenkamp, B S, Nieslanik, E C, Dietze, G, Tai, C, Ibarra, W M, Atkins

Publikováno v: Proteins. 42(2)

Twelve C-terminal residues of human glutathione S-transferase A1-1 form a helix in the presence of glutathione-conjugate, or substrate alone, and partly cover the active site. According to X-ray structures, the helix is disordered in the absence of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::43b88ba0c8be6b2552ee8bc90f9c7721
https://pubmed.ncbi.nlm.nih.gov/11119643

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The locally denatured state of glutathione S-transferase A1-1: transition state analysis of ligand-dependent formation of the C-terminal helix

Autor: B S, Nieslanik, E C, Dietze, W M, Atkins, I L, Trong, E, Adman

Publikováno v: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing.

On the basis of available x-ray structures, A-class glutathione S-transferases (GSTs) contain at their C-termini a short alpha-helix that provides a 'lid' over the active site in the presence of the reaction products, glutathione-conjugates. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b0ef1ad52ca7b8bf1dd4a07111ce78d6
https://pubmed.ncbi.nlm.nih.gov/10380227

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Retinoic acid-mediated G1-S-phase arrest of normal human mammary epithelial cells is independent of the level of p53 protein expression

Autor: V L, Seewaldt, E C, Dietze, B S, Johnson, S J, Collins, M B, Parker

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 10(1)

Retinoids mediate the normal growth of a variety of epithelial cells and may play an important role in the chemoprevention of breast cancer. Despite the widespread clinical use of retinoids, specific target genes that are regulated by retinoids are r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::085d37391ac5b5d1bc2166110d1d7d21
https://pubmed.ncbi.nlm.nih.gov/9950218

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