Zobrazeno 1 - 10
of 27
pro vyhledávání: '"E C, Arner"'
Publikováno v:
Inflammation Research. 47:115-121
Objective: To evaluate the effect of the antioxidant-like anti-inflammatory agent, ebselen, on cartilage proteoglycan degradation and to determine whether its cartilage protectant activity is related to its antioxidant activity.¶Materials and Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e2030aed6b70bbbfbb1b0dafc93b6d
https://doi.org/10.1007/s000110050296
https://doi.org/10.1007/s000110050296
Autor:
Stephen W. Wright, Bruce Freimark, Jean M. Williams, M. A. Pratta, Ronald L. Magolda, E. C. Arner, Susan R. Sherk, Joseph J. Petraitis, John V. Giannaras
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:851-858
A series of 2,5-diarylisothiazolones is reported that inhibit the IL-1β-induced breakdown of bovine nasal septum cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds represent a nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f524fc6f62e35e4cecae110c5d8558a4
https://doi.org/10.1016/0968-0896(96)00053-3
https://doi.org/10.1016/0968-0896(96)00053-3
Autor:
Stephen W. Wright, Douglas Guy Batt, M. A. Pratta, Joseph J. Petraitis, Ronald L. Magolda, E. C. Arner, Susan R. Sherk, John V. Giannaras, Donald Joseph-Phillip Pinto, Orwat Michael James, Ronald L. Corbett, Bruce Freimark, Jean M. Williams, Susan V. Di Meo, Herman F. Stampfli
Publikováno v:
Bioorganic & Medicinal Chemistry. 3:227-234
A series of 2-(arylmethyl)pyridoisothiazolones is reported that inhibit the IL-1 β induced breakdown of bovine nasal septum cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5b6f7bd4ce3596c642a1014e6fbbe1
https://doi.org/10.1016/0968-0896(95)00018-c
https://doi.org/10.1016/0968-0896(95)00018-c
Autor:
William Henry Miller, M. A. Pratta, E. C. Arner, Robert J. McHugh, Donald Joseph-Phillip Pinto, Ronald L. Magolda
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:843-846
Several aryl-fused isothiazoloquinolinones were prepared and were found to inhibit IL-1β induced degradation of bovine nasal cartilage in an organ culture assay. These compounds, derived conceptually from the benzisothiazolone ring system, represent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94e50d33476fe37d56df61cc83ecfe2d
https://doi.org/10.1016/s0960-894x(01)80860-x
https://doi.org/10.1016/s0960-894x(01)80860-x
Publikováno v:
Experimental Cell Research. 206:58-62
Interleukin-1 beta (IL-1) increases the synthesis of prostaglandins as well as the expression of synovial fluid phospholipase A2 (PLA2) mRNA and activity by chondrocytes. In order to examine the potential involvement of cyclooxygenase in the inductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f52d6379a9734d3ccdcb4dbbda3355
https://doi.org/10.1006/excr.1993.1120
https://doi.org/10.1006/excr.1993.1120
Autor:
Robert A. Copeland, R. J. Cherney, Dayton T. Meyer, E. C. Arner, L. Wang, Carl P. Decicco, D. J. Nelson, Karl D. Hardman
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a56b20bf3db3fbe4c1d8819238c8bc14
https://doi.org/10.1002/chin.199746199
https://doi.org/10.1002/chin.199746199
Autor:
Karl D. Hardman, Jingwu Duan, Robert R. Copeland, Chen Linhua, Chu-Biao Xue, Carl P. Decicco, Maryanne B. Covington, E. C. Arner, Zelda R. Wasserman
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2403359d87e40bade08c1079f9ec40f
https://doi.org/10.1002/chin.199937175
https://doi.org/10.1002/chin.199937175
Publikováno v:
Experimental Cell Research. 195:462-467
Studies to evaluate the effects of recombinant interleukin-1 beta (IL-1) on the expression of matrix proteins by rabbit articular chondrocytes were conducted. Chondrocytes expressed high levels of message for thrombospondin (Tsp) and fibronectin (Fn)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1486c7f6d603feda7f03095bbdb3d52d
https://doi.org/10.1016/0014-4827(91)90397-d
https://doi.org/10.1016/0014-4827(91)90397-d
Autor:
Rui-Qin Liu, Timothy Burn, Kathleen Murphy, Gregory Hollis, Stuart A. Rosenfeld, Barbara H. Wiswall, Robert A. Copeland, Yoshifumi Itoh, Carl P. Decicco, Hideaki Nagase, F. Yang, Robert C. Bruckner, Robert C. Newton, James M. Trzaskos, Henry J. George, Richard Wynn, J. L. Duke, Ronald L. Magolda, Dawn Ellis, Michael A. Pratta, A. Rockwell, Ilgar Abbaszade, E. C. Arner, Harold D. Ross, M.C. Hillman, Micky D. Tortorella, Kimberly A. Solomon, Jeannine M. Hollis
Publikováno v:
Science. 284:1664-1666
We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases. Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs–4 (ADAMTS-4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc2a5018fca3fd44f5c1740c2430b66
https://doi.org/10.1126/science.284.5420.1664
https://doi.org/10.1126/science.284.5420.1664
Autor:
W, Yao, Z R, Wasserman, M, Chao, G, Reddy, E, Shi, R Q, Liu, M B, Covington, E C, Arner, M A, Pratta, M, Tortorella, R L, Magolda, R, Newton, M, Qian, M D, Ribadeneira, D, Christ, R R, Wexler, C P, Decicco
Publikováno v:
Journal of medicinal chemistry. 44(21)
A pharmacophore model of the P1' site, specific for aggrecanase, was defined using the specificity studies of the matrix metalloproteinases and the similar biological activity of aggrecanase and MMP-8. Incorporation of the side chain of a tyrosine re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66b60bcb0ff1f67244f659e6c7b37881
https://pubmed.ncbi.nlm.nih.gov/11585439
https://pubmed.ncbi.nlm.nih.gov/11585439