Evaluation of variable new antigen receptors (vNARs) as a novel cathepsin S (CTSS) targeting strategy

Autor: P. Smyth, L. Ferguson, J. F. Burrows, R. E. Burden, S. R. Tracey, Ú. M. Herron, M. Kovaleva, R. Williams, A. J. Porter, D. B. Longley, C. J. Barelle, C. J. Scott

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Aberrant activity of the cysteine protease Cathepsin S (CTSS) has been implicated across a wide range of pathologies. Notably in cancer, CTSS has been shown to promote tumour progression, primarily through facilitating invasion and migration of tumou

Externí odkaz: https://doaj.org/article/c73d1a2f27044702b9125d5d2cae26d0

Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer

Autor: Naphannop Sereesongsaeng, Sara H. McDowell, James F. Burrows, Christopher J. Scott, Roberta E. Burden

Publikováno v: Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)

Abstract Background Lysosomal cysteine protease cathepsin V has previously been shown to exhibit elevated expression in breast cancer tissue and be associated with distant metastasis. Research has also identified that cathepsin V expression is elevat

Externí odkaz: https://doaj.org/article/f0f6b2ce326a44db8cf62786ac66b46c

USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells

Autor: Aidan P. McCann, Peter Smyth, Francesco Cogo, William J. McDaid, Lai Jiang, Jia Lin, Emma Evergren, Roberta E. Burden, Sandra Van Schaeybroeck, Christopher J. Scott, James F. Burrows

Publikováno v: Cell Communication and Signaling, Vol 16, Iss 1, Pp 1-12 (2018)

Abstract Background The deubiquitinase USP17 is overexpressed in NSCLC and has been shown to be required for the growth and motility of EGFR wild-type (WT) NSCLC cells. USP17 is also required for clathrin-mediated endocytosis of EGFR. Here, we examin

Externí odkaz: https://doaj.org/article/389459c8bc77420cac6802a897ba1482

Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer

Autor: James F Burrows, Naphannop Sereesongsaeng, Roberta E. Burden, Sara H. McDowell, Christopher J. Scott

Publikováno v: Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)
Breast Cancer Research : BCR
Sereesongsaeng, N, McDowell, S H, Burrows, J F, Scott, C J & Burden, R E 2020, ' Cathepsin V suppresses GATA3 protein expression in luminal A breast cancer ', Breast Cancer Research, vol. 22, no. 1, pp. 139 . https://doi.org/10.1186/s13058-020-01376-6

Background Lysosomal cysteine protease cathepsin V has previously been shown to exhibit elevated expression in breast cancer tissue and be associated with distant metastasis. Research has also identified that cathepsin V expression is elevated in tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e326b94e680b509b4ca766211d4bb8
https://doaj.org/article/f0f6b2ce326a44db8cf62786ac66b46c

USP17 is required for peripheral trafficking of lysosomes

Autor: Jia Lin, Aidan P McCann, Naphannop Sereesongsaeng, Jonathan M Burden, Alhareth A Alsa’d, Roberta E Burden, Ileana Micu, Richard Williams, Sandra Van Schaeybroeck, Emma Evergren, Paul Mullan, Jeremy C Simpson, Christopher J Scott, James F Burrows

Publikováno v: Lin, J, McCann, A, Sereesongsaeng, N, Burden, J, Alsa'd, A A M, Burden, R, Micu, I, Williams, R, Van Schaeybroeck, S, Evergren, E, Mullan, P, Scott, C & Burrows, J 2022, ' USP17 is required for peripheral trafficking of lysosomes ', EMBO Reports . https://doi.org/10.15252/embr.202051932

Expression of the deubiquitinase USP17 is induced by multiple stimuli, including cytokines (IL-4/6), chemokines (IL-8, SDF1), and growth factors (EGF), and several studies indicate it is required for cell proliferation and migration. However, the mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1620489c446b5d366be14ac3cfc91d68
https://doi.org/10.15252/embr.202051932