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Akademický článek

Myosin VI drives arrestin-independent internalization and signaling of GPCRs

Autor: Nishaben M. Patel, Léa Ripoll, Chloe J. Peach, Ning Ma, Emily E. Blythe, Nagarajan Vaidehi, Nigel W. Bunnett, Mark von Zastrow, Sivaraj Sivaramakrishnan

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract G protein-coupled receptor (GPCR) endocytosis is canonically associated with β-arrestins. Here, we delineate a β-arrestin-independent endocytic pathway driven by the cytoskeletal motor, myosin VI. Myosin VI engages GIPC, an adaptor protein

Externí odkaz: https://doaj.org/article/3dee4150cd6f48cb81a29bb29098c782

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Cenozoic slip along the southern Sierra Nevada normal fault, California (USA): A long-lived stable western boundary of the Basin and Range

Autor: Jeffrey Lee, Daniel F. Stockli, Ann E. Blythe

Publikováno v: Geosphere. 19:878-899

The uplift history of the Sierra Nevada, California, is a topic of long-standing disagreement with much of it centered on the timing and nature of slip along the range-bounding normal fault along the east flank of the southern Sierra Nevada. The hist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b67a7c2dd9b7bd8c8b99da73c7273074
https://doi.org/10.1130/ges02574.1

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Akademický článek

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A discrete mode of endosomal GPCR signaling that does not require β-arrestin

Autor: Emily E. Blythe, Mark von Zastrow

The ability of GPCRs to initiate a second phase of G protein-coupled signaling after endocytosis is now well established. The prevailing current view is that GPCR signaling from endosomes is strictly dependent on β-arrestin. Here we revise this view

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6fd595c80d902f04e511b69a261bf3a
https://doi.org/10.1101/2022.09.07.506997

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Digitizing The Land of Genghis Khan: Reforming Mongolia’s Internet Law to Achieve Growth in E-Commerce

Autor: Stephen E. Blythe

Publikováno v: International Journal of Humanities and Applied Social Science. :1-7

In the digital age, the E-signature has replaced the handwritten signature. Since 1995, there have been three generations of E-signature law: the first mandated use of the digital signature, the second recognized the legal validity of all types of E-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6189b043f71241c20417e10ad60357b3
https://doi.org/10.33642/ijhass.v6n7p1

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Cambodia’s New Digital Signature, E-Commerce and Consumer Protection Laws: Key Components of a Bold Strategy for Dramatic Future Economic Growth

Autor: Stephen E. Blythe

Publikováno v: International Journal of Social Science and Public Policy. :1-12

Cambodia has a bold new strategy to stimulate E-commerce and to grow the economy. The Digital Signature (DSL), Consumer Protection (CPL), and E-Commerce Laws (ECL) are important components of that strategy. The DSL provides for licensing of certifyin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a2b740181f0954dd221d6b5c2202441
https://doi.org/10.33642/ijsspp.v3n7p1

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Increasing conception rate by addition of a second prostaglandin injection in an Ovsynch and progesterone treatment programme for dairy cows not detected in oestrus before the start of the seasonal mating period

Autor: A Karkaba, E Blythe, S McDougall, R Castle, Y Macpherson

Publikováno v: New Zealand Veterinary Journal. 69:211-223

To assess the effect on conception rate to first service, 3- and 6-week in-calf rates, final pregnancy rate and the hazard of pregnancy, of addition of a second prostaglandin (PG) injection 24 hours after the first, in a synchrony programme combining

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25449775a22d4e0811fb0ac4371a135a
https://doi.org/10.1080/00480169.2021.1906343

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Uplift and exhumation in Haida Gwaii driven by terrane translation and transpression along the southern Queen Charlotte fault, Canada

Autor: Eric Morley, William A. Matthews, Alison R. Duvall, Ann E. Blythe, Sean Richard LaHusen, P. Schoettle-Greene

Publikováno v: Geology. 48:908-912

The mountainous archipelago of Haida Gwaii abuts the transpressive Pacific–North American plate margin north of the Cascadia subduction zone (northwestern North America). Topography on Haida Gwaii has been attributed to either dynamic uplift suppor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0e5a1476649026a0831c9053d7f213b
https://doi.org/10.1130/g47364.1

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Profiling the diversity of agonist-selective effects on the proximal proteome environment of G protein-coupled receptors

Autor: Benjamin J. Polacco, Braden T. Lobingier, Emily E. Blythe, Nohely Abreu, Jiewei Xu, Qiongyu Li, Zun Zar Chi Naing, Brian K. Shoichet, Joshua Levitz, Nevan J. Krogan, Mark Von Zastrow, Ruth Hüttenhain

G protein-coupled receptors (GPCRs) regulate many aspects of physiology and represent actionable targets for drug discovery. These receptors translate ligand-dependent input into a cellular response by remodeling protein interaction networks that are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f7536df9f3183f718a6b7c16539af5f
https://doi.org/10.1101/2022.03.28.486115

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