Zobrazeno 1 - 10 of 60 pro vyhledávání: '"E Binderup"'
1
Examination of structurally selective derivatization of vitamin D(3) analogues by electrospray mass spectrometry
Autor: A S, Weiskopf, P, Vouros, J, Cunniff, E, Binderup, F, Björkling, L, Binderup, M C, White, G H, Posner
Publikováno v: Journal of mass spectrometry : JMS. 36(1)
The structural specificity of vitamin D derivatization by PTAD (4-phenyl-1,2,4-triazoline-3,5-dione) was probed using synthetic analogues and ion trap mass spectrometry. EB 1089, a vitamin D(3) analogue which contains a second site for Diels--Alder c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6b0b2649189ad6981960cf4de749fec0
https://pubmed.ncbi.nlm.nih.gov/11180648
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2
Seocalcitol (EB 1089): a vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation
Autor: C M Hansen, E Binderup, K J Hamberg, L Binderup
Publikováno v: Current pharmaceutical design. 6(7)
It is well established that the metabolically active form of vitamin D, 1alpha,25-dihydroxyvitamin D 3 (1alpha,25(OH)2 D 3 ) plays a key role in the establishment and maintenance of the calcium metabolism in the body. In addition to this classic effe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534f3a83dbd9ca05dbeb22641a058866
https://pubmed.ncbi.nlm.nih.gov/10828309
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3
Metabolism of the vitamin D3 analogue EB1089 alters receptor complex formation and reduces promoter selectivity
Autor: M, Quack, C, Mørk Hansen, E, Binderup, A M, Kissmeyer, C, Carlberg
Publikováno v: British journal of pharmacology. 125(4)
1. 1alpha,25-dihydroxyvitamin3 (VD) is a nuclear hormone that has important cell regulatory functions but also a strong calcemic effect. EB1089 is a potent antiproliferative VD analogue, which has a modified side chain resulting in increased metaboli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8eaf20a9c2c2300e5682e66c1036004
https://pubmed.ncbi.nlm.nih.gov/9831892
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4
The vitamin D analog, KH1060, is rapidly degraded both in vivo and in vitro via several pathways: principal metabolites generated retain significant biological activity
Autor: Graham R. Williams, E. Binderup, Glenville Jones, M. J. Calverley, A.-M. Kissmeyer, F. J. Dilworth, J. L. Nielsen, Hugh L.J. Makin
Publikováno v: Scopus-Elsevier
Vitamin D analogs are valuable drugs with established and potential uses in hyperproliferative disorders. Lexacalcitol (KH1060) is over 100 times more active than 1alpha,25-dihydroxyvitamin D3 [1alpha,25-(OH)2D3], as judged by in vitro antiproliferat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2087df31f9422f90c8f4bbf9ed1483
https://pubmed.ncbi.nlm.nih.gov/9389535
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8
Mutual pro-drugs of .BETA.-lactam antibiotics and .BETA.-lactamase inhibitors
Autor: W. O. Godtfredsen, B. Baltzer, H. Sorensen, W. von Daehne, E. Binderup, B. Nielsen, S. Vangedal, K. Hansen
Publikováno v: The Journal of Antibiotics. 33:1183-1192
The principle of combining a beta-lactam antibiotic with a beta-lactamase inhibitor in a single molecule functioning as pro-drug for the two active components is illustrated by the linked esters 3 and 4 in which ampicillin and mecillinam, respectivel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0574fc1ab082e521ee7c7974254009
https://doi.org/10.7164/antibiotics.33.1183
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9
Chlorosulfates as Reagents in the Synthesis of Carboxylic Acid Esters Under Phase-Transfer Conditions
Autor: E. Binderup, E. T. Hansen
Publikováno v: Synthetic Communications. 14:857-864
During a search for a satisfactory synthesis of chloromethyl esters 1 of certain β-lactam antibiotics, e.g. penicillanic acid sulfone, we discovered that chloromethyl chlorosulfate1 (4) is an excellent reagent for this purpose. We also found that ot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de66566e41ebbd44841a9baa8c90fb72
https://doi.org/10.1080/00397918408075729
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