Zobrazeno 1 - 10
of 383
pro vyhledávání: '"E B Smith"'
Autor:
Amanda Laine, Xiaoxing Wang, Kathryn Ni, Sarah E. B. Smith, Rayan Najjar, Leanne S. Whitmore, Michael Yacoub, Alison Bays, Michael Gale, Tomas Mustelin
Publikováno v:
Microorganisms, Vol 11, Iss 5, p 1310 (2023)
Many patients suffering from autoimmune diseases have autoantibodies against proteins encoded by genomic retroelements, suggesting that normal epigenetic silencing is insufficient to prevent the production of the encoded proteins for which immune tol
Externí odkaz:
https://doaj.org/article/352ff31df8624e8a8791342210f63991
Publikováno v:
Clinical Diabetes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::702f7894c9d50f73197616cc173ce0d5
https://doi.org/10.2337/cd22-0132
https://doi.org/10.2337/cd22-0132
Autor:
Peder L. Myhre, Omemi, Dennis W.T. Nilsen, E B Smith, Svein Solheim, Harald Arnesen, Kristian Laake, Pål Smith, A A Kalstad, Arnljot Tveit, Ingebjørg Seljeflot, Sjur H Tveit
Publikováno v:
European Heart Journal. 42
Background In the OMEMI trial, elderly post-MI patients did not achieve reduction in cardiovascular events from supplementation of 1.8g n-3 polyunsaturated fatty acids (PUFA). In two recent trials of hypertriglyceridaemic patients the REDUCE-IT trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::448ffd40a80d12b9088f6a35defe1c14
https://doi.org/10.1093/eurheartj/ehab724.2429
https://doi.org/10.1093/eurheartj/ehab724.2429
Publikováno v:
2020 Integrated Communications Navigation and Surveillance Conference (ICNS).
When National Airspace System (NAS) flight demand (e.g., Flight Operator operations) exceeds capacity (e.g., airport-, weather-, airspace-related) at a NAS resource the result is delay. To ensure an efficient NAS, the Federal Aviation Administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::818807456f9589e274ae436600b9123f
https://doi.org/10.1109/icns50378.2020.9222980
https://doi.org/10.1109/icns50378.2020.9222980
Autor:
Antoine Maruani, Stephen Caddick, Eifion Robinson, Mark E. B. Smith, João P. Nunes, Vessela Vassileva, James R. Baker, R. Barbara Pedley, João C. F. Nogueira, Vijay Chudasama
Publikováno v:
RSC Advances. 7:9073-9077
Herein we report the use of pyridazinediones to functionalise the native solvent accessible interstrand disulfide bonds in trastuzumab with monomethyl auristatin E (MMAE). This method of conjugation delivers serum stable antibody–drug conjugates (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f284be16884546ad478e386f9a1e0e5
https://doi.org/10.1039/c7ra00788d
https://doi.org/10.1039/c7ra00788d
Autor:
Maurício Morais, João P. M. Nunes, Kersti Karu, Nafsika Forte, Irene Benni, Mark E. B. Smith, Stephen Caddick, Vijay Chudasama, James R. Baker
Publikováno v:
Organic & Biomolecular Chemistry. 19:3024-3024
Correction for ‘Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis’ by Maurício Morais et al., Org. Biomol. Chem., 2017, 15, 2947–2952, DOI: 10.1039/C7OB00220C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ae235c812945331eb2686689513a69
https://doi.org/10.1039/d1ob90035h
https://doi.org/10.1039/d1ob90035h
Publikováno v:
Organic & Biomolecular Chemistry. 13:4165-4168
Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f715a1e82de5f3721bd8169c2de3fa19
https://doi.org/10.1039/c5ob00130g
https://doi.org/10.1039/c5ob00130g
Autor:
James R. Baker, Vijay Chudasama, Eifion Robinson, João P. Nunes, Vineeth Rajkumar, Mark E. B. Smith, Vessela Vassileva, Maurício Morais, R. Barbara Pedley, Stephen Caddick
Publikováno v:
Chemical Communications. 51:10624-10627
Herein we report the use of next generation maleimides (NGMs) for the construction of a potent antibody-drug conjugate (ADC) via functional disulfide bridging. The linker has excellent stability in blood serum and the ADC, armed with monomethyl auris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f9fa72c4c115be6015ea6b27195ed3
https://doi.org/10.1039/c5cc03557k
https://doi.org/10.1039/c5cc03557k
Autor:
Maurício, Morais, João P M, Nunes, Kersti, Karu, Nafsika, Forte, Irene, Benni, Mark E B, Smith, Stephen, Caddick, Vijay, Chudasama, James R, Baker
Publikováno v:
Organicbiomolecular chemistry. 15(14)
Disulfide bridging offers a convenient approach to generate site-selective antibody conjugates from native antibodies. To optimise the reagents available to achieve this strategy, we describe here the use of dibromomaleimides designed to undergo acce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::39775d91677efaf4b141088794ca3489
https://pubmed.ncbi.nlm.nih.gov/33885556
https://pubmed.ncbi.nlm.nih.gov/33885556
Autor:
Vijay Chudasama, Stephen Caddick, Antoine Maruani, Huguette Savoie, Ross W. Boyle, Francesca Bryden, Mark E. B. Smith
Publikováno v:
Bioconjugate Chemistry. 25:611-617
The rapidly increasing interest in the synthesis of antibody-drug conjugates as powerful targeted anticancer agents demonstrates the growing appreciation of the power of antibodies and antibody fragments as highly selective targeting moieties. This t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3559bb146319eeaf119dffbf97d33c52
https://doi.org/10.1021/bc5000324
https://doi.org/10.1021/bc5000324