Zobrazeno 1 - 10
of 27
pro vyhledávání: '"E Allen, Sickmier"'
Autor:
Yue Hao, Whitney E Purtha, Christa Cortesio, Huan Rui, Yan Gu, Hao Chen, E Allen Sickmier, Paolo S Manzanillo, Xin Huang
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218063 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0200374.].
Externí odkaz:
https://doaj.org/article/34fad8c3366b45b7b5552fa19e5be426
Autor:
Yue Hao, Whitney Purtha, Christa Cortesio, Huan Rui, Yan Gu, Hao Chen, E Allen Sickmier, Paolo Manzanillo, Xin Huang
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200374 (2018)
Cathepsin H is a member of the papain superfamily of lysosomal cysteine proteases. It is the only known aminopeptidase in the family and is reported to be involved in cancer and other major diseases. Like many other proteases, it is synthesized as an
Externí odkaz:
https://doaj.org/article/bc889651b61041d4af51369ee8d2fabc
Autor:
Jennifer Castro, Matthew H. Daniels, Chuang Lu, David Brennan, Deepali Gotur, Young-Tae Lee, Kevin Knockenhauer, April Case, Jie Wu, Shane M. Buker, Julie Liu, Brian A. Sparling, E. Allen Sickmier, Stephen J. Blakemore, P. Ann Boriack-Sjodin, Kenneth W. Duncan, Scott Ribich, Robert A. Copeland
Publikováno v:
Cancer Research. 83:1136-1136
DHX9 is a multifunctional DEAH-box ATP-independent RNA helicase which has been reported to play important roles in replication, transcription, translation, RNA splicing and RNA processing which contribute to DHX9’s role in maintenance of genomic st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8c337e484014a2fd0111880ff8a940
https://doi.org/10.1158/1538-7445.am2023-1136
https://doi.org/10.1158/1538-7445.am2023-1136
Autor:
E Allen Sickmier, Robert J M Kurzeja, Klaus Michelsen, Mukta Vazir, Evelyn Yang, Andrew S Tasker
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163366 (2016)
Panitumumab and cetuximab target the epidermal growth factor receptor for the treatment of metastatic colorectal cancer. These therapies provide a significant survival benefit to patients with metastatic colorectal cancer with wild-type RAS. A single
Externí odkaz:
https://doaj.org/article/9714291c953e4ed38fccb50a2c3b5208
Autor:
Michael D. Bartberger, Vijay Keshav Gore, Mark R. Fielden, Ryan White, Qingyian Liu, E. Allen Sickmier, Stephen J. Wood, Jonathan D. Low, Jonathan Werner, Yuan Cheng, Dean Hickman, Hugo M. Vargas, Douglas A. Whittington, Ana Elena Minatti, Kui Chen
Publikováno v:
MedChemComm. 8:1196-1206
As part of an ongoing effort at Amgen to develop a disease-modifying therapy for Alzheimer's disease, we have previously used the aminooxazoline xanthene (AOX) scaffold to generate potent and orally efficacious BACE1 inhibitors. While AOX-BACE1 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13830ea11dc0c121fd4aa2ff4514c50d
https://doi.org/10.1039/c7md00106a
https://doi.org/10.1039/c7md00106a
Autor:
Christa L. Cortesio, Paolo Manzanillo, Whitney E. Purtha, Hao Chen, E. Allen Sickmier, Yan Gu, Xin Huang, Yue Hao, Huan Rui
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218063 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0200374.].
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9361aeedfd73c3129e8550fde4c0cba2
http://europepmc.org/articles/PMC6557506?pdf=render
http://europepmc.org/articles/PMC6557506?pdf=render
Autor:
Mirna Mujacic, John B. Jordan, Pranhitha Reddy, Aleksander Swietlow, Vivian S. W. Li, Tisha San Miguel, Paul Kodama, Anne-Marie C Rousseau, Seb Caille, E. Allen Sickmier, Michael J. Frohn, Dhanashri Bagal, Steve Osgood, Christopher H. Fotsch, Ki Won Kim, John D. McCarter, Mike Achmatowicz, Oliver R. Thiel, Alex Pickrell, Yong-Jae Kim, John G. Allen
Publikováno v:
ACS Chemical Biology. 11:2734-2743
The efficacy of therapeutic antibodies that induce antibody-dependent cellular cytotoxicity can be improved by reduced fucosylation. Consequently, fucosylation is a critical product attribute of monoclonal antibodies produced as protein therapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7973a8b4af60302b46b36632b02c9cd0
https://doi.org/10.1021/acschembio.6b00460
https://doi.org/10.1021/acschembio.6b00460
Autor:
E. Allen Sickmier, Paolo Manzanillo, Huan Rui, Whitney E. Purtha, Hao Chen, Yue Hao, Christa L. Cortesio, Yan Gu, Xin Huang
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 7, p e0200374 (2018)
PLoS ONE, Vol 13, Iss 7, p e0200374 (2018)
Cathepsin H is a member of the papain superfamily of lysosomal cysteine proteases. It is the only known aminopeptidase in the family and is reported to be involved in cancer and other major diseases. Like many other proteases, it is synthesized as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f787ba39b534feee9fec636b7fbcc38e
https://pubmed.ncbi.nlm.nih.gov/31181113
https://pubmed.ncbi.nlm.nih.gov/31181113
Autor:
Kevin Gaida, Xuxia Zhang, Robin Elliott, Benxian Liu, Andrea Itano, Cynthia Park, Justin K. Murray, Colin V. Gegg, Jennifer Aral, Les P. Miranda, Joseph G. McGivern, Hongyan Li, Anne Colombero, E. Allen Sickmier, Kevin Salyers, Michael Stenkilsson, Jonathan Werner, Steven Yu, Mark J. Rose, John K. Sullivan, Yi-Xin Qian, Peter Miu, Kristin L. Andrews
Publikováno v:
Journal of Medicinal Chemistry. 58:6784-6802
To realize the medicinal potential of peptide toxins, naturally occurring disulfide-rich peptides, as ion channel antagonists, more efficient pharmaceutical optimization technologies must be developed. Here, we show that the therapeutic properties of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ed4b88835ea36a6e04bf82dabb3f1f
https://doi.org/10.1021/acs.jmedchem.5b00495
https://doi.org/10.1021/acs.jmedchem.5b00495
Autor:
John B, Jordan, Douglas A, Whittington, Michael D, Bartberger, E Allen, Sickmier, Kui, Chen, Ryan D, White, Yuan, Cheng, Ted, Judd
Publikováno v:
Journal of medicinal chemistry. 60(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da5615b8703b81b5b0cdb606b6571616
https://pubmed.ncbi.nlm.nih.gov/26978477
https://pubmed.ncbi.nlm.nih.gov/26978477