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Akademický článek
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Autor:
Münster PN; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. munstepn@moffitt.usf.edu, Basso A, Solit D, Norton L, Rosen N
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2001 Aug; Vol. 7 (8), pp. 2228-36.
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(8)
17-allyl-aminogeldanamycin (17-AAG) is an ansamycin antibiotic that binds to a highly conserved pocket in the Hsp90 chaperone protein and inhibits its function. Hsp90 is required for the refolding of proteins during cellular stress and the conformati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8728eeba2c43ba49270c6ce7fa6e0b07
https://pubmed.ncbi.nlm.nih.gov/11489788
https://pubmed.ncbi.nlm.nih.gov/11489788
Autor:
Wang, Lin1 (AUTHOR), Wang, Shihang1 (AUTHOR), Yang, Hao1 (AUTHOR), Li, Shiwei1 (AUTHOR), Wang, Xinyu1 (AUTHOR), Zhou, Yongqi1 (AUTHOR), Tian, Siyuan1 (AUTHOR), Liu, Lu1 (AUTHOR), Bai, Fang2 (AUTHOR) baifang@shanghaitech.edu.cn
Publikováno v:
Advanced Science. 10/28/2024, Vol. 11 Issue 40, p1-14. 14p.
Autor:
E. A. Sausville, M. Monga
Publikováno v:
Leukemia. 16:520-526
As the drug discovery and developmental arm of the National Cancer Institute (NCI), the Developmental Therapeutics Program (DTP) plans, conducts and facilitates development of therapeutic agents for cancer and AIDS. DTP's goal is to turn 'molecules i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d9c9c8aaefc54502dd33f57f3be5c9
https://doi.org/10.1038/sj.leu.2402464
https://doi.org/10.1038/sj.leu.2402464
Publikováno v:
Bioconjugate Chemistry. 12:711-718
Ellipticine derivatives have potential as anticancer drugs. Their clinical use has been limited, however, by poor solubility and host toxicity. As N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-anticancer conjugates are showing promise in early c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05632796bc9fb46bae3e9f742d6e597a
https://doi.org/10.1021/bc0001544
https://doi.org/10.1021/bc0001544
Autor:
J I Johnson, E A Sausville
Publikováno v:
British Journal of Cancer
A new approach to cancer drug discovery targets molecules important in cancer pathogenesis. This approach is thought to be of greater promise than the antiproliferative screens which discovered cytotoxic agents and dominated cancer drug discovery for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3ca31e6a64a36f33151f0e3b0d77a1
https://doi.org/10.1054/bjoc.2000.1473
https://doi.org/10.1054/bjoc.2000.1473
Autor:
E. A. Sausville, E. Feigal
Publikováno v:
Annals of Oncology. 10:1287-1292
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1ddf1e8ec694f7366714c6f72da3da
https://doi.org/10.1023/a:1008333901925
https://doi.org/10.1023/a:1008333901925
Autor:
Schneider, Carolin1, Hilbert, Jorina1, Genevaux, Franziska2, Höfer, Stefanie3, Krauß, Lukas1, Schicktanz, Felix4, Contreras, Constanza Tapia1, Jansari, Shaishavi5, Papargyriou, Aristeidis2,6,7,8, Richter, Thorsten1, Alfayomy, Abdallah M.9,10, Falcomatà, Chiara11,12, Schneeweis, Christian11, Orben, Felix2, Öllinger, Ruppert13, Wegwitz, Florian5, Boshnakovska, Angela14, Rehling, Peter14,15, Müller, Denise16, Ströbel, Philipp16,17,18
Publikováno v:
Advanced Science. 8/21/2024, Vol. 11 Issue 31, p1-18. 18p.
Autor:
Murali, Aparna1 (AUTHOR), Brokesh, Anna M.1 (AUTHOR), Cross, Lauren M.1 (AUTHOR), Kersey, Anna L.1 (AUTHOR), Jaiswal, Manish K.1 (AUTHOR), Singh, Irtisha1,2,3 (AUTHOR) isingh@tamu.edu, Gaharwar, Akhilesh1,3,4 (AUTHOR) gaharwar@tamu.edu
Publikováno v:
Advanced Science. 8/7/2024, Vol. 11 Issue 29, p1-16. 16p.