Zobrazeno 1 - 10
of 38
pro vyhledávání: '"E A Gulve"'
Autor:
E. A. Gulve, Lorraine A. Nolte, John O. Holloszy, May M. Chen, Polly A. Hansen, Jane M. Schluter
Publikováno v:
Diabetes. 47:721-726
It has been hypothesized that increased production of tumor necrosis factor-alpha (TNF-alpha) plays a role in causing the insulin resistance associated with obesity. Obesity with insulin resistance is associated with increased production of TNF-alpha
Publikováno v:
American Journal of Physiology-Cell Physiology. 273:C1082-C1087
beta-Adrenergic stimulation has been reported to inhibit insulin-stimulated glucose transport in adipocytes. This effect has been attributed to a decrease in the intrinsic activity of the GLUT-4 isoform of the glucose transporter that is mediated by
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 272:E1080-E1088
Enhanced glucose flux via the hexosamine biosynthetic pathway has been implicated in insulin resistance. We measured products of this pathway, UDP-N-acetyl hexosamines (UDP-HexNAc), and activity of the rate-limiting enzyme L-glutamine:D-fructose-6-ph
Autor:
R. J. Spina, E. A. Gulve
Publikováno v:
Journal of Applied Physiology. 79:1562-1566
Previous studies in animals and humans have shown that endurance exercise-training protocols of several weeks to many months in duration induce adaptive increases in skeletal muscle GLUT-4 protein concentration. It is generally assumed that the incre
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 268:R997-R1002
There is evidence that an increase in sarcoplasmic Ca2+ stimulates glucose transport in muscle. Recent studies have provided the apparently conflicting finding that a sustained increase in cytosolic Ca2+ has little effect on basal glucose transport b
Autor:
Jeffrey E. Pessin, John O. Holloszy, Mike Mueckler, E. A. Gulve, Bess A. Marshall, Jiaping Gao, Polly A. Hansen
Publikováno v:
Journal of Biological Chemistry. 270:1679-1684
Skeletal muscle glucose transport and metabolism were studied in a line of transgenic mice overexpressing the human Glut4 facilitative glucose transporter. Skeletal muscle Glut4 protein levels were increased 2-4-fold in transgenic animals relative to
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 267:R888-R894
The calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) stimulates glucose transport in skeletal muscle, apparently by raising cytosolic Ca2+ (P. Palade. J. Biol. Chem. 262: 6142-6148, 1987; J.H. Youn, E.A. Gulve, and J.O.
Publikováno v:
Diabetes. 43:903-907
Lithium is thought to have an insulin-like effect on glucose transport and metabolism in skeletal muscle and adipocytes. However, we found that lithium had only a minimal effect on basal glucose transport activity in rat epitrochlearis muscles. Inste
Autor:
E. A. Gulve, M. Mueckler, Jian-Ming Ren, Bess A. Marshall, Jiaping Gao, John O. Holloszy, Polly A. Hansen
Publikováno v:
Journal of Biological Chemistry. 269:18366-18370
Glucose transport activity was examined in transgenic mice overexpressing the human GLUT1 glucose transporter in skeletal muscles. Basal transport activity measured in vitro with the glucose analog 2-deoxy-D-glucose (1 mM) was increased 2-8-fold in f
Publikováno v:
Journal of Biological Chemistry. 269:14396-14401
GLUT4 glucose transporter content and glucose transport capacity are closely correlated in skeletal muscle. In this study, we tested the hypothesis that a rapid increase in GLUT4 expression occurs as part of the early adaptive response of muscle to e