Zobrazeno 1 - 10
of 77
pro vyhledávání: '"E A, Sausville"'
Autor:
E. A. Sausville, M. Monga
Publikováno v:
Leukemia. 16:520-526
As the drug discovery and developmental arm of the National Cancer Institute (NCI), the Developmental Therapeutics Program (DTP) plans, conducts and facilitates development of therapeutic agents for cancer and AIDS. DTP's goal is to turn 'molecules i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d9c9c8aaefc54502dd33f57f3be5c9
https://doi.org/10.1038/sj.leu.2402464
https://doi.org/10.1038/sj.leu.2402464
Publikováno v:
Bioconjugate Chemistry. 12:711-718
Ellipticine derivatives have potential as anticancer drugs. Their clinical use has been limited, however, by poor solubility and host toxicity. As N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-anticancer conjugates are showing promise in early c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05632796bc9fb46bae3e9f742d6e597a
https://doi.org/10.1021/bc0001544
https://doi.org/10.1021/bc0001544
Autor:
J I Johnson, E A Sausville
Publikováno v:
British Journal of Cancer
A new approach to cancer drug discovery targets molecules important in cancer pathogenesis. This approach is thought to be of greater promise than the antiproliferative screens which discovered cytotoxic agents and dominated cancer drug discovery for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3ca31e6a64a36f33151f0e3b0d77a1
https://doi.org/10.1054/bjoc.2000.1473
https://doi.org/10.1054/bjoc.2000.1473
Autor:
E. A. Sausville, E. Feigal
Publikováno v:
Annals of Oncology. 10:1287-1292
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1ddf1e8ec694f7366714c6f72da3da
https://doi.org/10.1023/a:1008333901925
https://doi.org/10.1023/a:1008333901925
Publikováno v:
Journal of Biological Chemistry. 268:3817-3820
Gastrin releasing peptide is mitogenic for mouse Swiss 3T3 fibroblasts and certain human small cell lung carcinoma (SCLC) cells but not for mouse Balb/c 3T3 fibroblasts. To identify new molecules associated with the gastrin releasing peptide-responsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e93eded00a5ea4327400742843191d9d
https://doi.org/10.1016/s0021-9258(18)53544-4
https://doi.org/10.1016/s0021-9258(18)53544-4
Autor:
J W, Lynch, I, Linoilla, E A, Sausville, S M, Steinberg, B C, Ghosh, D T, Nguyen, G P, Schechter, A B, Fischmann, D C, Ihde, J L, Stocker
Publikováno v:
Blood. 79:3293-3299
We investigated the correlation between the detection of clonal rearrangement of the T-cell antigen receptor gene (TCRR) in lymph node tissue with histopathologic lymph node classification in 33 patients with mycosis fungoides with and without the Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854e5fc145ca7a8907ea758c5d4f89f7
https://doi.org/10.1182/blood.v79.12.3293.3293
https://doi.org/10.1182/blood.v79.12.3293.3293
Publikováno v:
Journal of Clinical Investigation. 86:1904-1912
Cholera toxin (CT) inhibited the in vitro growth of three of four human small-cell lung carcinoma (SCLC) cell lines with a 50% inhibitory concentration of 27-242 ng/ml. Loss of surface membrane ruffling and the capacity of [Tyr4]-bombesin, vasopressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03703fbe1f3037f799cac763a539068f
https://doi.org/10.1172/jci114923
https://doi.org/10.1172/jci114923
Publikováno v:
European journal of cancer (Oxford, England : 1990). 40(6)
The in vivo hollow fibre model was developed by the National Cancer Institute (NCI) in the United States of America (USA) at a time when the number of potential anti-cancer drugs arising from in vitro screening efforts exceeded the available capacity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a0f2235399e21f044dfe59946842ebe
https://pubmed.ncbi.nlm.nih.gov/15120037
https://pubmed.ncbi.nlm.nih.gov/15120037
Autor:
E A, Sausville
Publikováno v:
Cancer metastasis reviews. 20(1-2)
New insights into cancer biology have allowed the definition of pathways critical to the success of the cancer cell. These include enhanced activity of positive regulators of cell proliferation, including oncogenes, and loss of tumor suppressor gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf459f7f9a2df00cf2b49294f76fbb03
https://pubmed.ncbi.nlm.nih.gov/11831639
https://pubmed.ncbi.nlm.nih.gov/11831639
Autor:
S G, Arbuck, J, Dancey, J M, Pluda, L, Grochow, A J, Murgo, P, Ivy, J, Wright, B, Blaylock, L E, Via, E A, Sausville
Publikováno v:
Cancer chemotherapy and biological response modifiers. 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e94d6118ee428ab7f1d5604bd56a7976
https://pubmed.ncbi.nlm.nih.gov/11686017
https://pubmed.ncbi.nlm.nih.gov/11686017