Zobrazeno 1 - 10
of 15
pro vyhledávání: '"E A, Konorev"'
Publikováno v:
Basic Research in Cardiology. 86:327-339
The purpose of this study was to find out whether Ca2+ is necessary for the protective effect of phosphocreatine (PCr) on ischemic myocardium. Isolated Langendorff-perfused rat hearts were used in the study. When ischemic arrest was induced in Ca(2+)
Publikováno v:
Bulletin of Experimental Biology and Medicine. 109:281-284
Publikováno v:
The Journal of biological chemistry. 275(43)
Doxorubicin (DOX) is a broad spectrum anthracycline antibiotic used to treat a variety of cancers. Redox activation of DOX to form reactive oxygen species has been implicated in DOX-induced cardiotoxicity. In this work we investigated DOX-induced apo
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 274(1)
The objective of this study was to assess the cardioprotective effect of the nitric oxide (.NO) donor, S-nitrosoglutathione (GSNO) and to investigate the mechanism of cardioprotection in a model of ischemia and reperfusion in isolated rat hearts. The
Publikováno v:
Kardiologiia. 32(3)
Publikováno v:
Biokhimiia (Moscow, Russia). 57(2)
The role of Ca2+ in the manifestation of the cardioprotective effect of phosphocreatine (PCr) on the ischemic myocardium was studied in isolated rat hearts perfused by the Langendorf method. Under ischemic cardiac arrest induced by a Ca(2+)-free perf
Publikováno v:
Biokhimiia (Moscow, Russia). 56(9)
The effects of phosphocreatine (PCr) and its analogues (creatine, phosphocreatinine, phosphoarginine and inorganic phosphate) on liposomal and erythrocyte membranes and on the sarcolemmal membrane of cardiomyocytes were studied. The ESR spectrum of t
Autor:
E A, Konorev, V A, Saks, D V, Rudnev, L A, Konorev, V G, Sharov, V E, Kagan, V V, Pichugin, R P, Evstigneeva
Publikováno v:
Vestnik Akademii meditsinskikh nauk SSSR. (3)
The effects of phosphocreatine and tocopheryl phosphate and their combined use in ischemia and reperfusion of the heart were studied in anesthetized dogs. The investigation focused on the size of myocardial infarction and left ventricular contractili
Publikováno v:
Biulleten' eksperimental'noi biologii i meditsiny. 110(9)
The effects of synthetic antioxidant emoxypine on infarct size and plasma creatine kinase (CK) activity was studied on open-chest anesthetized dogs with 180-min myocardial ischemia followed by reperfusion. Emoxypine (10 and 40 mg/kg) was injected int
Publikováno v:
Biulleten' eksperimental'noi biologii i meditsiny. 109(3)
Oxidative damage of the isolated perfused rat heart was caused by addition of 90 microM H2O into Krebs-Henseleit solution. After 20 min of H2O2 addition an elevation of diastolic pressure (irreversible contracture) was observed followed by decrease o