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Akademický článek

The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons.

Autor: Michael P Nicoll, William Hann, Maitreyi Shivkumar, Laura E R Harman, Viv Connor, Heather M Coleman, João T Proença, Stacey Efstathiou

Publikováno v: PLoS Pathogens, Vol 12, Iss 4, p e1005539 (2016)

Herpes simplex virus 1 (HSV-1) establishes life-long latent infection within sensory neurons, during which viral lytic gene expression is silenced. The only highly expressed viral gene product during latent infection is the latency-associated transcr

Externí odkaz: https://doaj.org/article/f4caff8f8fb647f38af1659e1e2223c7

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The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons

Autor: Viv Connor, Stacey Efstathiou, João T. Proença, Maitreyi Shivkumar, William Hann, Heather M. Coleman, Michael P. Nicoll, Laura E. R. Harman

Publikováno v: PLoS Pathogens, Vol 12, Iss 4, p e1005539 (2016)
PLoS Pathogens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d92dfbe8cdedcf0a0bfc85e6faf36cc5
http://europepmc.org/articles/PMC4824392?pdf=render

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Hedgehog Signaling in Gastrointestinal Development and Disease

Autor: Seung K. Kim, E. B. Harman, Andrew H. Ko

Publikováno v: Current Molecular Medicine. 2:67-82

The development of the gastrointestinal (GI) tract and its associated parenchymal organs depends on Hedgehog signals from the endoderm to the surrounding mesoderm. During development, Hedgehog signaling is essential for patterning the GI tract along

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd80b4223d2dff7b4b8289b68265bc81
https://doi.org/10.2174/1566524023363130

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Enhancement of CD8(+) T-cell memory by removal of a vaccinia virus nuclear factor-κB inhibitor

Autor: Hongwei, Ren, Brian J, Ferguson, Carlos, Maluquer de Motes, Rebecca P, Sumner, Laura E R, Harman, Geoffrey L, Smith

Publikováno v: Immunology

Factors influencing T-cell responses are important for vaccine development but are incompletely understood. Here, vaccinia virus (VACV) protein N1 is shown to impair the development of both effector and memory CD8(+) T cells and this correlates with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b19a063cc07dab9579925ca81041323
https://pubmed.ncbi.nlm.nih.gov/25382035

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Mode of virus rescue determines the acquisition of VHS mutations in VP22-negative herpes simplex virus 1

Autor: Gillian Elliott, Katja Ebert, Laura E. R. Harman, Daniel P. Depledge, Judith Breuer

Publikováno v: Journal of virology. 87(18)

It has been proposed that herpes simplex virus 1 with VP22 deleted requires secondary mutation of VHS for viability. Here we show that a replication-competent Δ22 virus constructed by homologous recombination maintains a wild-type (Wt) VHS gene and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9405731d5f22e20ecde47b32e5b96e1c
https://pubmed.ncbi.nlm.nih.gov/23864617

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Injuries in women associated with a periodized strength training and running program

Autor: K L, Reynolds, E A, Harman, R E, Worsham, M B, Sykes, P N, Frykman, V L, Backus

Publikováno v: Journal of strength and conditioning research. 15(1)

Forty-five women participated in a 24-week physical training program designed to improve lifting, load carriage, and running performance. Activities included weightlifting, running, backpacking, lift and carry drills, and sprint running. Physicians d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::20999ab71f3079f40a1b02f146c02fbd
https://pubmed.ncbi.nlm.nih.gov/11708698

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Effects of a World Record Unsupported Ski Trek Across Greenland (The G2 Expedition) on Physical Performance and Body Composition

Autor: E. A. Harman, P. K. Opstad, J. F. Patton, P. N. Frykman, R. W. Hoyt

Prolonged exhaustive physical exertion is often predicted to result in reduced performance capacity ("overtraining"), through mechanisms of tissue breakdown and inadequate time for full recuperation. This is of importance in military operations, wher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1e03089241461a5b746cb4e437b0237
https://doi.org/10.21236/ada396385

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Resistance training modes: specificity and effectiveness

Autor: M C, Morrissey, E A, Harman, M J, Johnson

Publikováno v: Medicine and science in sports and exercise. 27(5)

There is considerable demand for information on the effectiveness of various resistance exercises for improving physical performance, and on how exercise programs must match functional activities to produce the greatest performance gains (training sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::984f87dea2bafb80557c189240a9d0e9
https://pubmed.ncbi.nlm.nih.gov/7674868

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Lower and upper body anaerobic performance in male and female adolescent athletes

Autor: B C, Nindl, M T, Mahar, E A, Harman, J F, Patton

Publikováno v: Medicine and science in sports and exercise. 27(2)

Little data exist for upper and lower body mechanical power capability of adolescent athletes. This study compared arm (A) and leg (L) anaerobic peak and mean power (PP and MP) of 20 male and 20 female adolescent athletes after normalization for body

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2d6856566d159beb1f40b5d7b82af54
https://pubmed.ncbi.nlm.nih.gov/7564980

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