Zobrazeno 1 - 10
of 1 970
pro vyhledávání: '"E A, Chiocca"'
Autor:
Favaro, Alice
L’ampia diffusione di graphic novel che raffigurano le mutazioni sociali, le crisi economiche e ambientali, i flussi migratori, la disuguaglianza, la discriminazione e la negazione dei diritti umani vede il fumetto come il protagonista e il mezzo e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b61d509d27c7035edd11d8045229fea6
Autor:
J. Bryan Iorgulescu, Neil Ruthen, Ryuhjin Ahn, Eleni Panagioti, Prafulla C. Gokhale, Martha Neagu, Maria C. Speranza, Benjamin K. Eschle, Kara M. Soroko, Raziye Piranlioglu, Meenal Datta, Shanmugarajan Krishnan, Kathleen B. Yates, Gregory J. Baker, Rakesh K. Jain, Mario L. Suvà, Donna Neuberg, Forest M. White, E. Antonio Chiocca, Gordon J. Freeman, Arlene H. Sharpe, Catherine J. Wu, David A. Reardon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe GL261 and CT2A syngeneic tumor lines are frequently used as immunocompetent orthotopic mouse models of human glioblastoma (huGBM) but demonstrate distinct differences in their responses to immunotherapy.MethodsTo decipher the cell-intri
Externí odkaz:
https://doaj.org/article/0d4ef411871943b490bc6d2c4f558fb2
Autor:
Marilin S. Koch, Mykola Zdioruk, Michal O. Nowicki, Alec M. Griffith, Estuardo Aguilar-Cordova, Laura K. Aguilar, Brian W. Guzik, Francesca Barone, Paul Peter Tak, Katharina Schregel, Michael S. Hoetker, James A. Lederer, E. Antonio Chiocca, Ghazaleh Tabatabai, Sean E. Lawler
Publikováno v:
Molecular Therapy: Oncolytics, Vol 26, Iss , Pp 275-288 (2022)
CAN-2409 is a replication-deficient adenovirus encoding herpes simplex virus (HSV) thymidine kinase (tk) currently in clinical trials for treatment of glioblastoma. The expression of tk in transduced cancer cells results in conversion of the pro-drug
Externí odkaz:
https://doaj.org/article/d1ff12c2b9db4d9895906f9830d6592e
Autor:
Marilin S. Koch, Mykola Zdioruk, Michal O. Nowicki, Michael S. Hoetker, Zachary T. Herbert, Francesca Barone, Paul P. Tak, E. Antonio Chiocca, Ghazaleh Tabatabai, Sean E. Lawler
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
RationaleCAN-2409 is a locally delivered oncolytic therapy, which results in vaccination against the injected tumor. CAN-2409 consists of a non-replicating adenovirus armed with the Herpes virus thymidine kinase, which metabolizes ganciclovir into a
Externí odkaz:
https://doaj.org/article/059541d246d54f58b9384666b90522ef
Autor:
Deepak Bhere, Sung Hugh Choi, Pim van de Donk, David Hope, Kiki Gortzak, Amina Kunnummal, Jasneet Khalsa, Esther Revai Lechtich, Clemens Reinshagen, Victoria Leon, Nabil Nissar, Wenya Linda Bi, Cheng Feng, Hongbin Li, Yu Shrike Zhang, Steven H. Liang, Neil Vasdev, Walid Ibn Essayed, Pablo Valdes Quevedo, Alexandra Golby, Naima Banouni, Anna Palagina, Reza Abdi, Brian Fury, Stelios Smirnakis, Alarice Lowe, Brock Reeve, Arthur Hiller, E. Antonio Chiocca, Glenn Prestwich, Hiroaki Wakimoto, Gerhard Bauer, Khalid Shah
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Abstract Cellular therapies offer a promising therapeutic strategy for the highly malignant brain tumor, glioblastoma (GBM). However, their clinical translation is limited by the lack of effective target identification and stringent testing in pre-cl
Externí odkaz:
https://doaj.org/article/c3728edd112e43e6baeb95ff129c6000
Autor:
Bo Xu, Lei Tian, Jing Chen, Jing Wang, Rui Ma, Wenjuan Dong, Aimin Li, Jianying Zhang, E. Antonio Chiocca, Balveen Kaur, Mingye Feng, Michael A. Caligiuri, Jianhua Yu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Oncolytic herpes simplex virus-1 lyses cancer cells while increases their immunogenicity. Blocking the CD47 “don’t eat me” signal on cancer cells promotes their phagocytosis by macrophages. Authors here show that oncolytic viruses expressing an
Externí odkaz:
https://doaj.org/article/a3ded407a8e84ba2981a8d05e9d3ad5a
Autor:
Joseph W. Jackson, Bonnie L. Hall, Marco Marzulli, Vrusha K. Shah, Lisa Bailey, E. Antonio Chiocca, William F. Goins, Gary Kohanbash, Justus B. Cohen, Joseph C. Glorioso
Publikováno v:
Molecular Therapy: Oncolytics, Vol 22, Iss , Pp 444-453 (2021)
Oncolytic herpes simplex viruses (oHSVs) have demonstrated efficient lytic replication in human glioblastoma tumors using immunodeficient mouse models, but early-phase clinical trials have reported few complete responses. Potential reasons for the la
Externí odkaz:
https://doaj.org/article/5c93d5fd70934a6081e8332d9b55751d
Autor:
Adrianne L. Jenner, Munisha Smalley, David Goldman, William F. Goins, Charles S. Cobbs, Ralph B. Puchalski, E. Antonio Chiocca, Sean Lawler, Paul Macklin, Aaron Goldman, Morgan Craig
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104395- (2022)
Summary: Oncolytic viruses (OVs) are emerging cancer immunotherapy. Despite notable successes in the treatment of some tumors, OV therapy for central nervous system cancers has failed to show efficacy. We used an ex vivo tumor model developed from hu
Externí odkaz:
https://doaj.org/article/ce0d47aff0b143b1858eb624b2a4a00d
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 871-893 (2020)
rQNestin34.5v.2 is an oncolytic herpes simplex virus 1 (oHSV) that retains expression of the neurovirulent ICP34.5 gene under glioma-selective transcriptional regulation. To prepare an investigational new drug (IND) application, we performed toxicolo
Externí odkaz:
https://doaj.org/article/eb2ba3ff62ef4e86bdbd6b80dbd6768d