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SUMMARY Several cytokines have been implicated individually in the pathogenesis of systemic lupus erythematosus (SLE) and some, including interleukin (IL)-10, IL-12 and IL-1ra are raised during flares of disease activity. Few studies have been direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85efc29cadf5e367e7c34dde262d7e2a
https://europepmc.org/articles/PMC1809203/
https://europepmc.org/articles/PMC1809203/
Autor:
E A, Capper, A K, Roshak, B J, Bolognese, P L, Podolin, T, Smith, D L, Dewitt, K M, Anderson, L A, Marshall
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 295(3)
Tranilast (SB 252218) is a compound initially identified as an anti-atopic agent. Recently the compound has demonstrated clear beneficial effects in animal models of restenosis. Here we confirm tranilast has broad and profound effects on human monocy