Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Eóin N. McNamee"'
Autor:
Agnieszka K. Czopik, Eóin N. McNamee, Victoria Vaughn, Xiangsheng Huang, In Hyuk Bang, Trent Clark, Yanyu Wang, Wei Ruan, Tom Nguyen, Joanne C. Masterson, Eunyoung Tak, Sandra Frank, Colm B. Collins, Howard Li, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Mark E. Gerich, Glenn T. Furuta, Xiaoyi Yuan, Anil K. Sood, Edwin F. de Zoeten, Holger K. Eltzschig
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Metabolic imbalance leading to inflammatory hypoxia and stabilization of hypoxia-inducible transcription factors (HIFs) is a hallmark of inflammatory bowel diseases. We hypothesize that HIF could be stabilized in CD4+ T cells during intestin
Externí odkaz:
https://doaj.org/article/a669e42b23f44430a2592da34005a047
Autor:
Juliet Hammer, Eóin N. McNamee, Rachel Harris, Kelley E. Capocelli, Glenn T. Furuta, Kathryn A. Biette, Caleb J. Kelly, Sean P. Colgan, Hiroshi Nakagawa, Nathalie Nguyen, Joanne C. Masterson, Stefan F. Ehrentraut, Faria N. Ahmed, Louise E. Glover, Bejan Saeedi, Lindsay Hosford, Shahan D. Fernando, Eric L. Campbell, James J. Lee
Publikováno v:
Journal of Clinical Investigation. 129:3224-3235
Epithelial barrier dysfunction is a significant factor in many allergic diseases, including eosinophilic esophagitis (EoE). Infiltrating leukocytes and tissue adaptations increase metabolic demands and decrease oxygen availability at barrier surfaces
Autor:
Joanne C. Masterson, Juliet Hammer, Kathryn A. Biette, Rachel Harris, Heather Miyazawa, Eóin N. McNamee, James J. Lee, Glenn T. Furuta
Publikováno v:
Allergy. 72:1232-1242
Background: Eosinophilic esophagitis (EoE) is a chronic antigen‐mediated clinicopathologic disease of the esophagus characterized by an eosinophil‐predominant inflammatory infiltrate. A clinical hallmark is extensive tissue remodeling including b
Autor:
Eóin N. McNamee
Neutrophil (PMN) infiltration of the intestinal mucosa is a hallmark of tissue injury associated with inflammatory bowel diseases (IBDs). The pathological effects of PMNs are largely attributed to the release of soluble mediators and reactive oxygen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ec4e3a7c86d2ea194b5efdb738cbe5
http://mural.maynoothuniversity.ie/10934/
http://mural.maynoothuniversity.ie/10934/
Autor:
Francisco Victorino, Heidi Ehrentraut, Holger K. Eltzschig, Kelley S. Brodsky, Lucy Golden-Mason, Sandra Hoegl, Eóin N. McNamee
Publikováno v:
Journal of Leukocyte Biology. 101:471-480
A critical step in the pathogenesis of acute lung injury (ALI) is excessive recruitment of polymorphonuclear neutrophils (PMNs) into the lungs, causing significant collateral tissue damage. Defining the molecular and cellular steps that control neutr
Autor:
S. Courtney Frasch, Sean P. Colgan, Claudia Jakubzick, Paul Jedlicka, James J. Lee, Karin A. Zemski Berry, Matthias Mack, Donna L. Bratton, Eóin N. McNamee, Peter M. Henson, Douglas J. Kominsky, Glenn T. Furuta
Publikováno v:
The Journal of Immunology. 197:1425-1434
Proinflammatory consequences have been described for lysophosphatidylcholine, a lipid product of cellular injury, signaling via the G protein–coupled receptor G2A on myeloid and lymphoid inflammatory cells. This prompted the hypothesis that genetic
Autor:
Francisco Victorino, Eóin N. McNamee, Holger K. Eltzschig, Dirk Homann, Kelley S. Brodsky, Dorothy K. Sojka, Eric T. Clambey, Joanne C. Masterson, Wayne M. Yokoyama
Publikováno v:
The Journal of Immunology. 195:4973-4985
NK cells are innate lymphoid cells important for immune surveillance, identifying and responding to stress, infection, and/or transformation. Whereas conventional NK (cNK) cells circulate systemically, many NK cells reside in tissues where they appea
Autor:
Martin G. Myers, Peter J. Dempsey, Nicholas H. Elder, Mark R. Frey, Jennifer C. Jones, Christopher M. Dekaney, Constance D. Brindley, Eóin N. McNamee, Noah F. Shroyer, Michael Rajala
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 533-554 (2019)
Background & Aims: Loss of leucine-rich repeat-containing G-protein–coupled receptor 5–positive crypt base columnar cells provides permissive conditions for different facultative stem cell populations to dedifferentiate and repopulate the stem ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1071110e4825da3466e59902eec945
http://mural.maynoothuniversity.ie/10935/
http://mural.maynoothuniversity.ie/10935/
Autor:
Jesus Rivera-Nieves, Eóin N. McNamee
Publikováno v:
Gastroenterology
The gut-associated lymphoid tissues are the guardians of the enteric immune system and integrate dietary and microbial stimuli to maintain immunologic tolerance. However, during periods of persistent chronic inflammation, such as in Crohn’s disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6723b8d097b2f68625a879df94ed0f43
https://europepmc.org/articles/PMC9924356/
https://europepmc.org/articles/PMC9924356/
Autor:
Owen Jensen, Matthias Mack, Luke A. J. O'Neill, Kelley S. Brodsky, Mark E. Cooper, Kathryn A. Biette, Charles A. Dinarello, Eóin N. McNamee, Seth L. Masters, Hazel Tye, Moritz Haneklaus, Glenn T. Furuta, Viola Neudecker, Holger K. Eltzschig, Paul Jedlicka, Avril A. B. Robertson, Mark E. Gerich, Ludmila Khailova, Joanne C. Masterson
Publikováno v:
Journal of Experimental Medicine, 214, 1737-1752
Journal of Experimental Medicine, 214, 6, pp. 1737-1752
The Journal of Experimental Medicine
Journal of Experimental Medicine, 214, 6, pp. 1737-1752
The Journal of Experimental Medicine
Neudecker et al. define a role for a microRNA, miR-223, in regulating the inflammatory tone of the intestine by constraining nlrp3 inflammasome activation in CCR2+ monocytes and attenuating excessive IL-1β–driven inflammation. Therapeutic nanopart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adc7a6b2f77b5c7ae776e147b187fa8
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/174781
https://hdl.handle.net/https://repository.ubn.ru.nl/handle/2066/174781