Zobrazeno 1 - 10
of 60
pro vyhledávání: '"E, de Kant"'
Autor:
G. A. Van Der Marel, E. de Kant, S. Hagens, R. de Haan, A. R. P. M. Valentijn, J. H. Van Boom, L.H. Cohen
Publikováno v:
Recueil des Travaux Chimiques des Pays-Bas. 114:332-336
A multi-step synthesis of phosphinylphosphonate analogue 12 of the proposed farnesyl-farnesyl-enzyme (FFE) intermediate in the enzymatic conversion of farnesyl pyrophosphate to squalene is described. In addition, evidence is presented of the inhibito
Autor:
T Sonntag, Christian Thiede, I. Heide, S Jonas, Christoph Rochlitz, Andreas Neubauer, Dieter Huhn, E. de Kant, Richard Herrmann, Peter Neuhaus, F.J Peter
Publikováno v:
European Journal of Cancer. 33:1314-1322
In order to investigate the role of TP53 in tumour progression and metastasis, we analysed 33 liver metastases of colorectal carcinomas and 19 primary colon carcinomas from the same hospital with respect to mutational changes, loss of heterozygosity
Publikováno v:
Oncology. 53:448-454
Overexpression and amplification of the c-myc oncogene occur in approximately 70 and 10% of human primary colorectal carcinomas, respectively, indicating the importance of this gene in colorectal tumorigenesis. Little, however, is known about the inv
Autor:
E, de Kant
Publikováno v:
Methods in molecular medicine. 26
Quantitative mRNA characterization by reverse transcription (RT) of RNA and subsequent polymerase chain reaction (PCR) (RT-PCR) is, compared to qualitative RT-PCR detection of RNA, more complicated because of two features inherent in in vitro amplifi
Autor:
Richard Herrmann, Dieter Huhn, C. A. Schmidt, E. de Kant, I. Heide, Peter Neuhaus, Andreas Neubauer, Christoph Rochlitz
Publikováno v:
British Journal of Cancer
Cells of a patient with Turcot's syndrome and of her parents were evaluated for the presence of molecular alterations in the p53 and the Ki-ras gene. Deletions on chromosome 17p, overexpression and point mutations of the p53 gene as well as mutations
Autor:
Stefan Peter, G. Willroth, Dieter Huhn, E. de Kant, Hartmut Lobeck, Christoph Rochlitz, Richard Herrmann
Publikováno v:
European Journal of Cancer. 28:333-336
Mutations in codon 12, 13 or 61 of one of the three ras genes, Ha-ras, Ki-ras, and N-ras, convert these genes into active oncogenes. To determine the role mutated ras genes play in the carcinogenesis of renal cell carcinoma, we analysed tumour DNA an
Autor:
E. de Kant, Richard Herrmann, A Lohri, J Reuter, Christoph Rochlitz, Christian Thiede, R. A. Popescu
Publikováno v:
European journal of cancer (Oxford, England : 1990). 34(8)
Apoptosis (programmed cell death) inhibition may be an important mechanism by which gastrointestinal mucosal cells containing damaged DNA evade normal clearance mechanisms and grow to become invasive tumours. Since bcl-2 is an apoptosis inhibitor, bc
Autor:
E, de Kant
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 86
Publikováno v:
Oncology. 53(6)
Overexpression and amplification of the c-myc oncogene occur in approximately 70 and 10% of human primary colorectal carcinomas, respectively, indicating the importance of this gene in colorectal tumorigenesis. Little, however, is known about the inv
Publikováno v:
Europe PubMed Central
Background : Alterations of the c-myc and the p53 genes occur in a majority of human colorectal cancers, and functional interaction between these two genes has recently been suggested. Patients and methods : We analyzed p53 sequence and c-myc and p53