Výsledky vyhledávání - "E, Zborowska"

Contextual effects of transforming growth factor beta on the tumorigenicity of human colon carcinoma cells

Autor: S C, Ye, J M, Foster, W, Li, J, Liang, E, Zborowska, S, Venkateswarlu, J, Gong, M G, Brattain, J K, Willson

Publikováno v: Cancer research. 59(18)

Transforming growth factor betas (TGF-betas) are a growth factor family with negative autocrine growth functions for most epithelial cells including colon carcinoma cell lines. Both type I (RI) and type II (RII) transmembrane TGF-beta receptors have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ccbf86232f7040bc4eb3617ae8b66ce7
https://pubmed.ncbi.nlm.nih.gov/10493532

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Detection of poly(ADP-ribose) polymerase cleavage in response to treatment with topoisomerase I inhibitors: a potential surrogate end point to assess treatment effectiveness

Autor: C M, Whitacre, E, Zborowska, J K, Willson, N A, Berger

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(3)

Cleavage of poly(ADP-ribose) polymerase (PARP) by caspases is a prominent characteristic of apoptosis or programmed cell death shown to be induced by topoisomerase (Topo) inhibitors. Because Topo I inhibitors have been shown to be effective in the tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a1496890c9061e6b6eeaaed809fc3aaf
https://pubmed.ncbi.nlm.nih.gov/10100720

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Expression of transforming growth factor-beta receptor type II and tumorigenicity in human breast adenocarcinoma MCF-7 cells

Autor: Y, Ko, S S, Banerji, Y, Liu, W, Li, J, Liang, H D, Soule, R J, Pauley, J K, Willson, E, Zborowska, M G, Brattain

Publikováno v: Journal of cellular physiology. 176(2)

To analyze transforming growth factor-beta (TGF-beta) response during MCF-7 cell progression, early passage (MCF-7E,200 passage) and late passage (MCF-7L,500 passage) cells were compared. MCF-7E cells showed an IC50 of approximately 10 ng/ml of TGF-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62687e9c500f380332f404667293d912
https://pubmed.ncbi.nlm.nih.gov/9648930

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A kinase-defective transforming growth factor-beta receptor type II is a dominant-negative regulator for human breast carcinoma MCF-7 cells

Autor: Michael G. Brattain, K. M. Koli, C. L. Arteaga, W. Li, Yong Ko, Sunandita S. Banerji, J. K. V. Willson, E. Zborowska

Publikováno v: International Journal of Oncology.

The role of transforming growth factor (TGF)-beta type II receptor (T beta RII) in TGF-beta resistance and tumor progression is now well recognized. To test the effects of T beta RII loss in determining malignancy, we transfected a T beta RII-express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b5285a5a812eae666740219031c514
https://doi.org/10.3892/ijo.12.1.87

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O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU

Autor: W P, Phillips, J K, Willson, S D, Markowitz, E, Zborowska, N H, Zaidi, L, Liu, N H, Gordon, S L, Gerson

Publikováno v: Cancer research. 57(21)

To evaluate the role of O6-alkylguanine-DNA alkyltransferase (AGT) in colon tumor chloroethylnitrosourea (CENU) resistance, AGT-deficient VACO 8 cells were transfected with a vector containing or lacking the human O6-methylguanine-DNA methyltransfera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b1809da9b4821559db5bcaabf5133115
https://pubmed.ncbi.nlm.nih.gov/9354444

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Topotecan increases topoisomerase IIalpha levels and sensitivity to treatment with etoposide in schedule-dependent process

Autor: C M, Whitacre, E, Zborowska, N H, Gordon, W, Mackay, N A, Berger

Publikováno v: Cancer research. 57(8)

To elucidate the effect of topoisomerase (Topo) I inhibitors in the modulation of Topo II levels and sensitivity to Topo II-directed drugs, athymic mice bearing SW480 human colon cancer xenografts were treated with simultaneous, subsequent, or distan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75395e3b4afdd92605fc3835361736a8
https://pubmed.ncbi.nlm.nih.gov/9108439

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Role of alpha 5 beta 1 integrin in determining malignant properties of colon carcinoma cells

Autor: J, Gong, D, Wang, L, Sun, E, Zborowska, J K, Willson, M G, Brattain

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 8(1)

We characterized the expression of alpha 5 beta 1 integrin in two distinct phenotypes of colon carcinoma cell lines. Highly invasive colon cell lines (designated Group I cell lines) expressed higher levels of integrin alpha 5 beta 1 mRNA and protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ccf58a02c6ba2b1f85929cd1ba5a1b40
https://pubmed.ncbi.nlm.nih.gov/8993837

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Sensitive enzymatic cycling assay for glutathione: measurements of glutathione content and its modulation by buthionine sulfoximine in vivo and in vitro in human colon cancer

Autor: S J, Berger, D, Gosky, E, Zborowska, J K, Willson, N A, Berger

Publikováno v: Cancer research. 54(15)

We have measured glutathione content in small tissue samples derived from biopsies of primary and metastatic human colon tumors and from colon cancer cell lines in tissue culture and xenografts in athymic mice. Measurements were performed using an en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::43d545dac43f089bad850dfebfe4c018
https://pubmed.ncbi.nlm.nih.gov/8033140

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