Zobrazeno 1 - 10 of 238 pro vyhledávání: '"E, Wales"'
1
Akademický článek
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states
Autor: David Yin-wei Lin, Lauren E Kueffer, Puneet Juneja, Thomas E Wales, John R Engen, Amy H Andreotti
Publikováno v: eLife, Vol 12 (2024)
Full-length Bruton’s tyrosine kinase (BTK) has been refractory to structural analysis. The nearest full-length structure of BTK to date consists of the autoinhibited SH3–SH2–kinase core. Precisely how the BTK N-terminal domains (the Pleckstrin
Externí odkaz: https://doaj.org/article/6893fa79a72b4e8bbfd35d28b126c009
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2
Akademický článek
Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency
Autor: Michelle S. Prew, Christina M. Camara, Thomas Botzanowski, Jamie A. Moroco, Noah B. Bloch, Hannah R. Levy, Hyuk-Soo Seo, Sirano Dhe-Paganon, Gregory H. Bird, Henry D. Herce, Micah A. Gygi, Silvia Escudero, Thomas E. Wales, John R. Engen, Loren D. Walensky
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Prew et al. uncovered a structural basis for human VLCAD deficiency that arises from point mutations within the enzyme’s membrane-binding region, which was shown to fold as a putative α-helical hairpin. Helix-breaking mutations selectively disrupt
Externí odkaz: https://doaj.org/article/e862c131a10741b096477d28809d47d0
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3
Akademický článek
The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core
Autor: Noah B. Bloch, Thomas E. Wales, Michelle S. Prew, Hannah R. Levy, John R. Engen, Loren D. Walensky
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The pro-apoptotic BAX protein is a monomer under homeostatic conditions and, in response to stress, transforms into oligomers that induce apoptosis. Here, the authors characterize structural features of BAX that individually stabilize the monomer whi
Externí odkaz: https://doaj.org/article/6094840e65e043afbdbb1d1b24daacd6
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4
Akademický článek
Differential impact of BTK active site inhibitors on the conformational state of full-length BTK
Autor: Raji E Joseph, Neha Amatya, D Bruce Fulton, John R Engen, Thomas E Wales, Amy Andreotti
Publikováno v: eLife, Vol 9 (2020)
Bruton’s tyrosine kinase (BTK) is targeted in the treatment of B-cell disorders including leukemias and lymphomas. Currently approved BTK inhibitors, including Ibrutinib, a first-in-class covalent inhibitor of BTK, bind directly to the kinase activ
Externí odkaz: https://doaj.org/article/a1e7c59bd7424b1ea7e5693fd82af544
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5
Akademický článek
Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX
Autor: Daniel T. Cohen, Thomas E. Wales, Matthew W. McHenry, John R. Engen, Loren D. Walensky
Publikováno v: Cell Reports, Vol 30, Iss 10, Pp 3229-3239.e6 (2020)
Summary: BCL-2 family proteins converge at the mitochondrial outer membrane to regulate apoptosis and maintain the critical balance between cellular life and death. This physiologic process is essential to organism homeostasis and relies on protein-p
Externí odkaz: https://doaj.org/article/d674418a0a83428c96204962babe54c6
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6
Simple and Fast Maximally Deuterated Control (maxD) Preparation for Hydrogen-Deuterium Exchange Mass Spectrometry Experiments
Autor: Daniele Peterle, John R. Engen, Thomas E. Wales
Publikováno v: Analytical chemistry. 94(28)
During the analysis steps of hydrogen-deuterium exchange (HDX) mass spectrometry (MS), there is an unavoidable loss of deuterons, or back-exchange. Understanding back-exchange is necessary to correct for loss during analysis, to calculate the absolut
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f21c2d9b38a5cab454804e64572248
https://pubmed.ncbi.nlm.nih.gov/35796687
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10
Akademický článek
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