Zobrazeno 1 - 10
of 177
pro vyhledávání: '"E, Verdun"'
Autor:
John P. Brabson, Tiffany Leesang, Yoon Sing Yap, Jingjing Wang, Minh Q. Lam, Byron Fang, Igor Dolgalev, Daniela A. Barbieri, Victoria Strippoli, Carolina P. Bañuelos, Sofia Mohammad, Peter Lyon, Sana Chaudhry, Dane Donich, Anna Swirski, Evan Roberts, Ivelisse Diaz, Daniel Karl, Helena Gomes Dos Santos, Ramin Shiekhattar, Benjamin G. Neel, Stephen D. Nimer, Ramiro E. Verdun, Daniel Bilbao, Maria E. Figueroa, Luisa Cimmino
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112027- (2023)
Summary: TET2 haploinsufficiency is a driving event in myeloid cancers and is associated with a worse prognosis in patients with acute myeloid leukemia (AML). Enhancing residual TET2 activity using vitamin C increases oxidized 5-methylcytosine (mC) f
Externí odkaz:
https://doaj.org/article/5e49692c1c5545df90f0bdb82844b32f
Autor:
Martín Somoza, Adriano Bertelli, Cecilia A. Pratto, Ramiro E. Verdun, Oscar Campetella, Juan Mucci
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
Trypanosoma cruzi infection induces a polyclonal B cell proliferative response characterized by maturation to plasma cells, excessive generation of germinal centers, and secretion of parasite-unrelated antibodies. Although traditionally reduced to th
Externí odkaz:
https://doaj.org/article/e393a2339de8468db7bc05188ff2e188
Autor:
Xiaoyu Jiang, Xiaoqing Lu, Yu Zhang, Leda Lacaria, Brett J. Schuchardt, David C. Mikles, Marco Magistri, Idoia García-Ramírez, Isidro Sanchez-Garcia, Amjad Farooq, Ramiro E. Verdun, Midhat H. Abdulreda, Vincent T. Moy, Izidore S. Lossos
Publikováno v:
Blood Advances, Vol 3, Iss 15, Pp 2286-2297 (2019)
Abstract: Human germinal center (GC)–associated lymphoma (HGAL) is an adaptor protein expressed in GC B cells. HGAL regulates cell motility and B-cell receptor (BCR) signaling, processes that are central for the successful completion of the GC reac
Externí odkaz:
https://doaj.org/article/6dc73614162c47b0bb5ebce608b6d197
Autor:
Pierre-Jacques Hamard, Gabriel E. Santiago, Fan Liu, Daniel L. Karl, Concepcion Martinez, Na Man, Adnan K. Mookhtiar, Stephanie Duffort, Sarah Greenblatt, Ramiro E. Verdun, Stephen D. Nimer
Publikováno v:
Cell Reports, Vol 24, Iss 10, Pp 2643-2657 (2018)
Summary: Protein arginine methyltransferase 5 (PRMT5) is overexpressed in many cancer types and is a promising therapeutic target for several of them, including leukemia and lymphoma. However, we and others have reported that PRMT5 is essential for n
Externí odkaz:
https://doaj.org/article/3f53d8256d1a4982a660f6bf4d6b6001
Autor:
Stephen P. Methot, Ludivine C. Litzler, Poorani Ganesh Subramani, Anil K. Eranki, Heather Fifield, Anne-Marie Patenaude, Julian C. Gilmore, Gabriel E. Santiago, Halil Bagci, Jean-François Côté, Mani Larijani, Ramiro E. Verdun, Javier M. Di Noia
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Activation-induced deaminase (AID) is important for inducing desirable mutations at the B cell receptor genes for effective antibody responses. Here the authors show that three key arginine residues of AID link AID-chromatin association with transcri
Externí odkaz:
https://doaj.org/article/4b68ae1b781848de928edd5a95b1ea1e
Autor:
Kerri-Ann Latchmansingh, Xiaoqiong Wang, Ramiro E. Verdun, Mario L. Marques-Piubelli, Francisco Vega, M. James You, Jennifer Chapman, Izidore S. Lossos
Publikováno v:
Mod Pathol
T- lymphoblastic leukemia / lymphoma (T-LL) is an aggressive malignancy of immature T-cells with poor overall survival (OS) and in need of new therapies. LIM-domain only 2 (LMO2) is a critical regulator of hematopoietic cell development that can be o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5797ae7094db7b6e31a2eebf68db16b
https://doi.org/10.1038/s41379-022-01063-1
https://doi.org/10.1038/s41379-022-01063-1
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic gamma-herpesvirus that causes AIDS-associated Kaposi sarcoma (KS) and several lymphoproliferative disorders. During the humoral immune response antigen-activated mature B cells acquire
Externí odkaz:
https://doaj.org/article/d411553938c74b6b9df962b0e1cf9669
Autor:
Liliana Garcia-Martinez, Andrew M. Adams, Ho Lam Chan, Yuichiro Nakata, Natalia Weich, Stephanie Stransky, Zhao Zhang, Mohamed Alshalalfa, Leonor Sarria, Brandon A. Mahal, Susan B. Kesmodel, Toni Celià-Terrassa, Zhijie Liu, Saverio Minucci, Daniel Bilbao, Simone Sidoli, Ramiro E. Verdun, Lluis Morey
Publikováno v:
Nat Struct Mol Biol
Resistance to cancer treatment remains a major clinical hurdle. Here, we demonstrate that the CoREST complex is a key determinant for endocrine resistance and ER+ breast cancer plasticity. In endocrine sensitive cells, CoREST is recruited to ERα/FOX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f21f2f0e3b3cabf591796cdf35bdb0d
https://europepmc.org/articles/PMC9707522/
https://europepmc.org/articles/PMC9707522/
Publikováno v:
Leukemia & Lymphoma. 62:2547-2550
LIM-domain only 2 (LMO2) is a highly conserved cysteine-rich protein that is a critical regulator of hematopoietic cell development, stem cell maintenance, and is implicated in angiogenesis [1,2]. ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10cefc36592498a75e7630f4d773405d
https://doi.org/10.1080/10428194.2021.1927020
https://doi.org/10.1080/10428194.2021.1927020
Autor:
Prevost, J., Van der Walt, A., Kalincik, T., Grand-Maison, F., McCombe, P., Butler, E., Lechner-Scott, J., di Cantogno, E. Verdun, Van Hijfte, L., Laureys, G., Ozakbas, SERKAN, Girard, M., Prat, A., Hodgkinson, S., Spelman, T., Butzkueven, H., Van Pesch, V., Macdonell, R., Oh, J., Alroughani, R., Grammond, P., Sanchez-Menoyo, J. -L., Terzi, M., Duquette, P., Madueno, S. Eichau, Izquierdo, G., Buzzard, K., Skabina, O.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2605::7c5e3b6533ba2d754f24b95dd08b45d3
https://avesis.deu.edu.tr/publication/details/930675be-0068-4de7-9f8f-1893d1cd5faf/oai
https://avesis.deu.edu.tr/publication/details/930675be-0068-4de7-9f8f-1893d1cd5faf/oai