Zobrazeno 1 - 10
of 44
pro vyhledávání: '"E, Venier"'
Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival
Autor:
Nathaniel D. Anderson, Yael Babichev, Fabio Fuligni, Federico Comitani, Mehdi Layeghifard, Rosemarie E. Venier, Stefan C. Dentro, Anant Maheshwari, Sheena Guram, Claire Wunker, J. Drew Thompson, Kyoko E. Yuki, Huayun Hou, Matthew Zatzman, Nicholas Light, Marcus Q. Bernardini, Jay S. Wunder, Irene L. Andrulis, Peter Ferguson, Albiruni R. Abdul Razak, Carol J. Swallow, James J. Dowling, Rima S. Al-Awar, Richard Marcellus, Marjan Rouzbahman, Moritz Gerstung, Daniel Durocher, Ludmil B. Alexandrov, Brendan C. Dickson, Rebecca A. Gladdy, Adam Shlien
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Heterogeneity in leiomyosarcomas (LMS) makes treatment of the disease challenging. Here the authors analyze LMS heterogeneity and molecular LMS subtypes using genomics and transcriptomics, finding origins in distinct lineages and associations with su
Externí odkaz:
https://doaj.org/article/c08bf52065ac4dcd90672db6a2810128
The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations
Autor:
Anita Villani, Scott Davidson, Nisha Kanwar, Winnie W. Lo, Yisu Li, Sarah Cohen-Gogo, Fabio Fuligni, Lisa-Monique Edward, Nicholas Light, Mehdi Layeghifard, Ricardo Harripaul, Larissa Waldman, Bailey Gallinger, Federico Comitani, Ledia Brunga, Reid Hayes, Nathaniel D. Anderson, Arun K. Ramani, Kyoko E. Yuki, Sasha Blay, Brittney Johnstone, Cara Inglese, Rawan Hammad, Catherine Goudie, Andrew Shuen, Jonathan D. Wasserman, Rosemarie E. Venier, Marianne Eliou, Miranda Lorenti, Carol Ann Ryan, Michael Braga, Meagan Gloven-Brown, Jianan Han, Maria Montero, Famida Spatare, James A. Whitlock, Stephen W. Scherer, Kathy Chun, Martin J. Somerville, Cynthia Hawkins, Mohamed Abdelhaleem, Vijay Ramaswamy, Gino R. Somers, Lianna Kyriakopoulou, Johann Hitzler, Mary Shago, Daniel A. Morgenstern, Uri Tabori, Stephen Meyn, Meredith S. Irwin, David Malkin, Adam Shlien
Publikováno v:
Nature Cancer. 4:203-221
We conducted integrative somatic–germline analyses by deeply sequencing 864 cancer-associated genes, complete genomes and transcriptomes for 300 mostly previously treated children and adolescents/young adults with cancer of poor prognosis or with r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cc564393b318b298215f3cddc8037c8
https://doi.org/10.1038/s43018-022-00474-y
https://doi.org/10.1038/s43018-022-00474-y
Autor:
Kelly M. Bailey, Linda M. McAllister-Lucas, Peter C. Lucas, Rajen Mody, Katherine A. Janeway, Kurt Weiss, Nivitha Periyapatna, Haley Raphael, Chandan Kumar-Sinha, Michelle F. Jacobs, Nathanael G. Bailey, Claire M. Julian, Rosemarie E. Venier, Elina Mukherjee, Jessica D. Daley, Lisa M. Maurer
Loss of GBP1 expression does not impact PSaRC318 cell migration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350842c1693c4a74b6a8acb40a758cf3
https://doi.org/10.1158/2767-9764.22544712
https://doi.org/10.1158/2767-9764.22544712
Autor:
Kelly M. Bailey, Linda M. McAllister-Lucas, Peter C. Lucas, Rajen Mody, Katherine A. Janeway, Kurt Weiss, Nivitha Periyapatna, Haley Raphael, Chandan Kumar-Sinha, Michelle F. Jacobs, Nathanael G. Bailey, Claire M. Julian, Rosemarie E. Venier, Elina Mukherjee, Jessica D. Daley, Lisa M. Maurer
Prevalence of somatic DNA damage repair gene variants in Ewing cell lines included in original studies of PARP inhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c9e36d9ddb5b10558a98c6dcb4644f
https://doi.org/10.1158/2767-9764.22544706.v1
https://doi.org/10.1158/2767-9764.22544706.v1
Autor:
Kelly M. Bailey, Linda M. McAllister-Lucas, Peter C. Lucas, Rajen Mody, Katherine A. Janeway, Kurt Weiss, Nivitha Periyapatna, Haley Raphael, Chandan Kumar-Sinha, Michelle F. Jacobs, Nathanael G. Bailey, Claire M. Julian, Rosemarie E. Venier, Elina Mukherjee, Jessica D. Daley, Lisa M. Maurer
Ewing sarcoma is a fusion oncoprotein–driven primary bone tumor. A subset of patients (∼10%) with Ewing sarcoma are known to harbor germline variants in a growing number of genes involved in DNA damage repair. We recently reported our discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa78735420778b69b3aa79e2eb85561
https://doi.org/10.1158/2767-9764.c.6550734
https://doi.org/10.1158/2767-9764.c.6550734
Autor:
Rosemarie E. Venier, Robin E. Grubs, Elena Kessler, Kristine L. Cooper, Kelly M. Bailey, Julia Meade
Publikováno v:
Journal of Genetic Counseling. 31:901-911
Cancer predisposition syndromes (CPS) are underdiagnosed in the pediatric population, though the diagnosis of a CPS has important implications for the child and their family. CPS are often diagnosed by geneticists or oncologists with expertise in CPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8458f49cc5b16013aae9b07e8435efe
https://doi.org/10.1002/jgc4.1559
https://doi.org/10.1002/jgc4.1559
Autor:
Jen Dorsey, Yael Babichev, Rosemarie E. Venier, Richard Marcellus, Rima Al-awar, Linda Z. Penn, Albiruni A. Razak, Brendan C. Dickson, Eric Chen, Irene L. Andrulis, Jay Wunder, Rebecca A. Gladdy
Publikováno v:
Clinical Cancer Research. 28:B014-B014
Introduction and Objective: Undifferentiated pleomorphic sarcoma (UPS) and leiomyosarcoma (LMS) are treated with surgery, radiation, and/or chemotherapy. Current drug therapies, such as doxorubicin, have limited response rates and severe toxicities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d73e4952523c675c881dc920175dabb
https://doi.org/10.1158/1557-3265.sarcomas22-b014
https://doi.org/10.1158/1557-3265.sarcomas22-b014
Autor:
Linda M. McAllister-Lucas, Haley Raphel, Kurt R. Weiss, Nathanael G. Bailey, Rosemarie E. Venier, Lisa M. Maurer, Rajen Mody, Chandan Kumar-Sinha, Michelle F. Jacobs, Katherine A. Janeway, Jessica D. Daley, Peter C. Lucas, Elina Mukherjee, Claire M. Julian, Kelly M. Bailey
Ewing sarcoma, an oncofusion-driven primary bone tumor, can occur in the setting of various germline mutations in DNA damage repair pathway genes. We recently reported our discovery of a germline mutation in the DNA damage repair protein BARD1 (BRCA1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35be12c668a5963bb0ab07f7d44a5d08
https://doi.org/10.1101/2020.09.18.304238
https://doi.org/10.1101/2020.09.18.304238
Genomic medicine and the use of genetic information in pediatric oncology has provided insight on the molecular underpinnings of childhood cancers and has demonstrated that cancer predisposition syndromes (CPS) are underdiagnosed. Diagnosis of a CPS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3f7a8c8bc22b19f5b7b29a29c6ef9d
https://doi.org/10.22541/au.159415223.38011765
https://doi.org/10.22541/au.159415223.38011765
Autor:
Rosemarie E. Venier, Kelly M. Bailey, Elena Kessler, Jean M. Tersak, Richard L. McGough, Sarangarajan Ranganathan, Julia Meade, Lisa M. Maurer, Marcus M. Malek, Kurt R. Weiss
Publikováno v:
Pediatric Blood & Cancer. 66
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd086c6aeb58ec86f35056fc535e1a1b
https://doi.org/10.1002/pbc.27824
https://doi.org/10.1002/pbc.27824