Zobrazeno 1 - 10
of 193
pro vyhledávání: '"E, Van Royen"'
Publikováno v:
Cells, Vol 13, Iss 20, p 1693 (2024)
The androgen receptor (AR), a member of the nuclear steroid hormone receptor family of transcription factors, plays a crucial role not only in the development of the male phenotype but also in the development and growth of prostate cancer. While AR s
Externí odkaz:
https://doaj.org/article/114d2f84ea904314806481cc2398bfd4
Autor:
Barbara Steurer, Roel C. Janssens, Marit E. Geijer, Fernando Aprile-Garcia, Bart Geverts, Arjan F. Theil, Barbara Hummel, Martin E. van Royen, Bastiaan Evers, René Bernards, Adriaan B. Houtsmuller, Ritwick Sawarkar, Jurgen Marteijn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
DNA damage inhibits elongating RNA polymerase II, but also initiates genome-wide transcriptional responses. Here the authors reveal that particularly promoter-bound Pol II is degraded upon DNA damage in a GSK3 signaling-mediated response.
Externí odkaz:
https://doaj.org/article/8ae0ddc4ec8841d3a8a8b7435095a252
Autor:
L. A. Erozenci, T. V. Pham, S. R. Piersma, N. F. J. Dits, G. W. Jenster, M. E. van Royen, R. J. A. Moorselaar, C. R. Jimenez, I. V. Bijnsdorp
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Urinary extracellular vesicles (EVs) have gained increased interest as a biomarker source. Clinical implementation on a daily basis requires protocols that inevitably includes short-term storage of the clinical samples, especially when colle
Externí odkaz:
https://doaj.org/article/025a5325a2264c839ebf332875fec65e
Autor:
Annelies Van Hemelryk, Sigrun Erkens-Schulze, Lifani Lim, Corrina M. A. de Ridder, Debra C. Stuurman, Guido W. Jenster, Martin E. van Royen, Wytske M. van Weerden
Publikováno v:
Cells, Vol 12, Iss 10, p 1377 (2023)
Tumor organoids have been pushed forward as advanced model systems for in vitro oncology drug testing, with the eventual goal to direct personalized cancer treatments. However, drug testing efforts suffer from a large variation in experimental condit
Externí odkaz:
https://doaj.org/article/d9b94a9c25aa4cd88b4d7be85f2dcdf8
Autor:
Silvia R. Vitale, Jean A. Helmijr, Marjolein Gerritsen, Hicret Coban, Lisanne F. van Dessel, Nick Beije, Michelle van der Vlugt-Daane, Paolo Vigneri, Anieta M. Sieuwerts, Natasja Dits, Martin E. van Royen, Guido Jenster, Stefan Sleijfer, Martijn Lolkema, John W. M. Martens, Maurice P. H. M. Jansen
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-17 (2021)
Abstract Background Extracellular vesicles (EVs) are actively secreted by cells into body fluids and contain nucleic acids of the cells they originate from. The goal of this study was to detect circulating tumor-derived EVs (ctEVs) by mutant mRNA tra
Externí odkaz:
https://doaj.org/article/72f7c191e7ba46759ff2867e41682c33
Autor:
Annelies Van Hemelryk, Ingrid Tomljanovic, Corrina M. A. de Ridder, Debra C. Stuurman, Wilma J. Teubel, Sigrun Erkens-Schulze, Esther I. Verhoef, Sebastiaan Remmers, Amrish J. Mahes, Geert J. L. H. van Leenders, Martin E. van Royen, Harmen J. G. van de Werken, Magda Grudniewska, Guido W. Jenster, Wytske M. van Weerden
Publikováno v:
Cells, Vol 11, Iss 22, p 3632 (2022)
Castration-resistant prostate cancer (CRPC) remains an incurable and lethal malignancy. The development of new CRPC treatment strategies is strongly impeded by the scarcity of representative, scalable and transferable preclinical models of advanced,
Externí odkaz:
https://doaj.org/article/9ed70a04355a4fed8481dd542b4ecb2b
Autor:
Gilles S van Tienderen, Oskar Rosmark, Ruby Lieshout, Jorke Willemse, Floor de Weijer, Linda Elowsson Rendin, Gunilla Westergren-Thorsson, Michail Doukas, Bas Groot Koerkamp, Martin E van Royen, Luc JW van der Laan, Monique MA Verstegen
Publikováno v:
Acta Biomaterialia, 158, 115-131. Elsevier
Patient-derived tumor organoids have been established as promising tools for in vitro modelling of multiple tumors, including cholangiocarcinoma (CCA). However, organoids are commonly cultured in basement membrane extract (BME) which does not recapit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::449c27609dd5f77df951c7d0a695e416
https://doi.org/10.1016/j.actbio.2022.11.038
https://doi.org/10.1016/j.actbio.2022.11.038
Autor:
Maurice de Wit, Ya Gao, Darlene Mercieca, Iris de Heer, Bart Valkenburg, Martin E. van Royen, Joachim Aerts, Peter Sillevis Smitt, Pim French
Publikováno v:
EBioMedicine, Vol 56, Iss , Pp 102796- (2020)
Background: Clinical responses to EGFR tyrosine kinase inhibitors (TKIs) are restricted to tumors harboring specific activating mutations and even then, not all tyrosine kinase inhibitors provide clinical benefit. All TKIs however, effectively inhibi
Externí odkaz:
https://doaj.org/article/4d3332bf8c9340df889230410d065f40
Autor:
Alex Pines, Madelon Dijk, Matthew Makowski, Elisabeth M. Meulenbroek, Mischa G. Vrouwe, Yana van der Weegen, Marijke Baltissen, Pim J. French, Martin E. van Royen, Martijn S. Luijsterburg, Leon H. Mullenders, Michiel Vermeulen, Wim Vermeulen, Navraj S. Pannu, Haico van Attikum
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
An integrated network of chaperones and protein degradation machineries called the proteostasis network (PN) is required to maintain protein homeostasis. Here the authors show that one of the components of the PN, the chaperonin TRiC, interacts with
Externí odkaz:
https://doaj.org/article/349d895dc8574c5db3919c1594d1d33a
Autor:
Annelies Van Hemelryk, Lisanne Mout, Sigrun Erkens-Schulze, Pim J. French, Wytske M. van Weerden, Martin E. van Royen
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1572 (2021)
Organoid-based studies have revolutionized in vitro preclinical research and hold great promise for the cancer research field, including prostate cancer (PCa). However, experimental variability in organoid drug testing complicates reproducibility. Fo
Externí odkaz:
https://doaj.org/article/721bef334d5b4664922d111ed7466a0c