Zobrazeno 1 - 10
of 95
pro vyhledávání: '"E, Toja"'
Autor:
E Toja, O Agostini
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 661:313-318
7-[(2,2-Dimethyl)propyl)]-1-methylxanthine (I, Lab code MX2/120) is a new potent antibronchospastic agent. A rapid and simple HPLC assay for I in guinea pig plasma has been developed. Compound I was extracted from plasma with dichloromethane by a sol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0873afa8315e968d0093ee28b7248f1
https://doi.org/10.1016/0378-4347(94)00339-4
https://doi.org/10.1016/0378-4347(94)00339-4
Autor:
E Toja, P. Hunt, M. L. Formento, Michel Fortin, Alina Butti, F. Barzaghi, A. Maggioni, A. Nencioni, C. Bonetti, Giulio Galliani
Publikováno v:
ChemInform. 23
On the basis of the knowledge acquired from basic studies of several known arecoline derivatives about the structural requirements for potent agonistic activity and oral efficacy, a series of 1-alkyl-1,2,5,6-tetrahydropyridine-3-carboxaldehyde- O -al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdbe223c5c14a43ba0f3c37e4298715f
https://doi.org/10.1002/chin.199218200
https://doi.org/10.1002/chin.199218200
Publikováno v:
ChemInform. 22
A series of 5-alkoxy-1-arylcarbonyl-2-pyrrolidinones ( 1–27 ) were prepared by condensation of arylcarbonyl chlorides with 5-alkoxy-2 pyrrolidinones in the presence of butyl lithium in tetrahydrofuran. Alkylation of these intermediates with substit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ea58c53c36510092931f32494249b4c
https://doi.org/10.1002/chin.199141141
https://doi.org/10.1002/chin.199141141
Autor:
F. Barzaghi, Alina Butti, A. Nencioni, C. Bonetti, M. L. Formento, A. Maggioni, P. Hunt, Giulio Galliani, E Toja, Michel Fortin
Publikováno v:
ChemInform. 24
Our previous attempts to design muscarinic agonists related to arecoline with the prerequisites for clinical use were successful with the discovery of 1,2,5,6-tetrahydropyridine-3-carboxaldehyde-O-methyloxime hydrochloride, RU 35963, and structurally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0d8de669e8dfb4667dce73aab42b65c
https://doi.org/10.1002/chin.199302195
https://doi.org/10.1002/chin.199302195
Autor:
O. Agostini, E. Toja, Stefano Evangelista, A Castellucci, Lido Ballati, G. Bonacchi, G. Di Marco, M. Borgianni, Boni P
Publikováno v:
ChemInform. 26
A series of 7-(2,2-dimethyl)propyl substituted xanthines were synthesized and tested for their antibronchospastic activity in comparison with theophylline. In vitro, the inhibition of carbachol-induced increase in bronchial tone was determined. In vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca6e94506824fc780630fcc33e962ab5
https://doi.org/10.1002/chin.199544170
https://doi.org/10.1002/chin.199544170
Autor:
Michel Fortin, Giulio Galliani, F. Barzaghi, P. Hunt, Alina Butti, A. Maggioni, E Toja, M. L. Formento, A. Nencioni, C. Bonetti
Publikováno v:
European Journal of Medicinal Chemistry. 27:519-526
Our previous attempts to design muscarinic agonists related to arecoline with the prerequisites for clinical use were successful with the discovery of 1,2,5,6-tetrahydropyridine-3-carboxaldehyde-O-methyloxime hydrochloride, RU 35963, and structurally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76fec0aa8ed2f6f016902c8f13c56012
https://doi.org/10.1016/0223-5234(92)90186-5
https://doi.org/10.1016/0223-5234(92)90186-5
Autor:
Michel Fortin, Giulio Galliani, Alina Butti, E Toja, M. L. Formento, F. Barzaghi, A. Maggioni, A. Nencioni, C. Bonetti, P. Hunt
Publikováno v:
European Journal of Medicinal Chemistry. 26:853-868
On the basis of the knowledge acquired from basic studies of several known arecoline derivatives about the structural requirements for potent agonistic activity and oral efficacy, a series of 1-alkyl-1,2,5,6-tetrahydropyridine-3-carboxaldehyde- O -al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67b1312eee03cb866aa9c74cafcf7bcf
https://doi.org/10.1016/0223-5234(91)90128-a
https://doi.org/10.1016/0223-5234(91)90128-a
Publikováno v:
European Journal of Medicinal Chemistry. 26:415-422
A series of 5-alkoxy-1-arylcarbonyl-2-pyrrolidinones ( 1–27 ) were prepared by condensation of arylcarbonyl chlorides with 5-alkoxy-2 pyrrolidinones in the presence of butyl lithium in tetrahydrofuran. Alkylation of these intermediates with substit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feabed0feba6eb34e2c3797120b0118c
https://doi.org/10.1016/0223-5234(91)90102-s
https://doi.org/10.1016/0223-5234(91)90102-s
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
Arzneimittel-Forschung. 45(6)
7-[(2,2-Dimethyl)propyl]-1-methyl xanthine (CAS 155006-67-0, MX2/120) is a new potent antibronchospastic agent with negligible side effects. The synthesis involves the alkylation of 3-benzyl-1-methyl xanthine with neopentyl bromide followed by remova
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c314a6c76f976199206b4415c173019
https://pubmed.ncbi.nlm.nih.gov/7646571
https://pubmed.ncbi.nlm.nih.gov/7646571