Zobrazeno 1 - 10
of 52
pro vyhledávání: '"E, Skaletsky"'
Publikováno v:
Viral Immunology. 5:71-79
Anti-idiotypic antibodies (Ab2s) generated against neutralizing antibodies (Ab1s) specific for feline infectious peritonitis virus (FIPV) were shown to be specific for paratope-associated idiotopes of the Ab1s and not against isotypic determinants. I
Publikováno v:
Journal of molecular biology. 275(5)
The structure of an intact monoclonal antibody for phenobarbital, subclass IgG1, has been determined to 3.2 A resolution by X-ray crystallography. The molecule was visualized in a monoclinic unit cell having an entire immunoglobulin as the asymmetric
Autor:
K, Ramnarayan, E, Skaletsky
Publikováno v:
American biotechnology laboratory. 13(9)
Humanized antibodies continue to be evaluated in clinical trials, and each trial will yield valuable information for the design of the next generation of humanized antibodies. More attention will be given to the use of antibody fragments and the sele
Autor:
E, Skaletsky, K, Ramnarayan
Publikováno v:
American biotechnology laboratory. 11(5)
Important structural information can be obtained from monoclonal antibodies through X-ray crystallographic analysis and computer modeling of CDR loops. These applications of monoclonal antibody technology offer new insights and novel approaches to th
Publikováno v:
The Journal of Immunology. 131:2595-2600
Malignant rabbit fibroma virus (MV) is a potent oncogenic poxvirus that produces a rapidly progressive syndrome of disseminated myxosarcoma, immunosuppression, and fatal gram-negative infection. MV is probably a recombinant between Shope fibroma viru
Publikováno v:
The Journal of Immunology. 130:399-404
Shope fibroma virus (SFV) causes a localized, self-limited, fibroblastic proliferation in adult rabbits. Extracts of Shope fibroma tumors were found to contain a second virus that induces a rapidly progressive disseminated tumor. Dissemination of thi
Publikováno v:
Symposium on Fundamental Cancer Research. 38
We have identified a recombinant leporipoxvirus that produces disseminated fibromas and a severe combined immune deficiency disease of sudden onset. The virus is recombinant between the SFV and the MV. MV was identified as a trace contaminant in stoc
Publikováno v:
American journal of veterinary research. 44(5)
Pasteurellosis in the rabbit inoculated with a malignant variant of Shope fibroma virus (SFV-MV) is presented as a model for the study of immunosuppression and immunoprophylaxis in pasteurellosis. The rabbits, before the inoculation, were healthy car
Publikováno v:
Cellular immunology. 86(1)
The ability of two related viruses--Shope fibroma virus (SFV) and malignant rabbit fibroma virus (MV)--to induce virus-specific immune responses in lymphocytes of recipient animals was studied. SFV produces a benign local tumor which regresses in 12-
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