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pro vyhledávání: '"E, Sausville"'
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Publikováno v:
Journal of Pediatric Urology. 5:308-314
Renal cell carcinoma (RCC) comprises about 5% of pediatric renal neoplasms. It has been recognized as a second malignancy in multiple reports. It is generally symptomatic at diagnosis, and most children with RCC present with more locally advanced dis
Autor:
Maryalice Stetler-Stevenson, Mark Raffeld, Douglas W. Kingma, Paula D. Imus, Robert J. Kreitman, David Venzon, Justin E. Sausville, Lynn Sorbara, Rita Salloum
Publikováno v:
American Journal of Clinical Pathology. 119:213-217
We studied 86 specimens from 24 patients with hairy cell leukemia (HCL) to determine the sensitivity of routine flow cytometry (FC) and consensus primer PCR (cpPCR) in this disease. FC was more sensitive, detecting HCL in 48 (56%) of 86 specimens, wh
Autor:
J B, Sunwoo, Z, Chen, G, Dong, N, Yeh, C, Crowl Bancroft, E, Sausville, J, Adams, P, Elliott, C, Van Waes
Publikováno v:
Clinical Cancer Research. 21:942-943
We have shown that activation of nuclear factor-kappa B (NF-kappa B) promotes cell survival and expression of cytokines such as growth-regulated oncogene-alpha, which can modulate angiogenesis, growth, and metastasis of squamous cell carcinoma (SCC).
Autor:
P J Worland, W.F. De Azevedo, H J Mueller-Dieckmann, Sung-Hou Kim, E Sausville, Ursula Schulze-Gahmen
Publikováno v:
Proceedings of the National Academy of Sciences. 93:2735-2740
The central role of cyclin-dependent kinases (CDKs) in cell cycle regulation makes them a promising target for studying inhibitory molecules that can modify the degree of cell proliferation. The discovery of specific inhibitors of CDKs such as polyhy
Autor:
Justin E, Sausville, Rita G, Salloum, Lynn, Sorbara, Douglas W, Kingma, Mark, Raffeld, Robert J, Kreitman, Paula D, Imus, David, Venzon, Maryalice, Stetler-Stevenson
Publikováno v:
American journal of clinical pathology. 119(2)
We studied 86 specimens from 24 patients with hairy cell leukemia (HCL) to determine the sensitivity of routine flow cytometry (FC) and consensus primer PCR (cpPCR) in this disease. FC was more sensitive, detecting HCL in 48 (56%) of 86 specimens, wh
Autor:
Pradip Amin, James W. Snider, William F. Regine, E. Sausville, Nader Hanna, M.E. Francis, H.R. Alexander
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 90:S767
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(2)
A retrospective analysis of 102 patients with relapsed, non-Hodgkin's lymphoma treated with two different ricin A chain-containing immunotoxins (ITs) in five Phase I clinical trials indicates that the dose-limiting toxicity, vascular leak syndrome, w
Publikováno v:
Biomedical chromatography : BMC. 14(5)
UCN-01, 7-hydroxystaurosporine, is an antagonist of protein kinase C, as well as causing cell cycle arrest. We developed and validated an HPLC assay method for the quantitation of UCN-01. Plasma and saliva standard curves were prepared at concentrati
Autor:
W H, Wilson, L, Sorbara, W D, Figg, E K, Mont, E, Sausville, K E, Warren, F M, Balis, K, Bauer, M, Raffeld, A M, Senderowicz, A, Monks
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(2)
Emerging evidence suggests that apoptosis is an important mechanism of tumor cell death from antineoplastic therapy. 7-hydroxystaurosporine (UCN-01) is a novel protein kinase inhibitor that increases chemotherapy-induced apoptosis in vitro and is in