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Malononitrilamides synergistically prevent acute and treat ongoing skin allograft rejection with cyclosporine

Autor: R. Kurrle, H. U. Schorlemmer, E. Ruuth

Publikováno v: Transplant International. 11:S340-S344

The low molecular weight malononitrilamides (MNAs), a new class of immunosuppressive agents, belong to the derivatives of leflunomide's active metabolite, A771726. They have been shown to bind specifically to dehydroorotate dehydrogenase and inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f2ca5b57ec99826a1de32d62ffc314
https://doi.org/10.1007/s001470050494

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Safety and Efficacy of Oral Fexofenadine in Children with Seasonal Allergic Rhinitis - a Pooled Analysis of Three Studies

Autor: E. Ruuth, Eli O. Meltzer, Ulrich Wahn, Claus Bachert, Albert F. Finn, José Rosado Pinto, Pierre Scheinmann, Gunilla Hedlin

Publikováno v: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP

Allergic rhinitis is one of the most common clinical conditions in children; however, data regarding the safety of antihistamines in children with seasonal allergic rhinitis are limiting. To evaluate the safety and efficacy of fexofenadine in childre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb05a633d3c663eededa5f5e34ad5338
https://hdl.handle.net/10400.17/2517

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Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis

Autor: E. Ruuth, Paola Decosta, Carlos E. Baena-Cagnani, Ulrich Wahn, Pierre Scheinmann, Albert F. Finn, Claus Bachert, Gunilla Hedlin, Paul Potter, F. Estelle R. Simons, Marek L. Kowalski, Eli O. Meltzer, José Rosado Pinto

Publikováno v: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP

This is the first prospective, randomized, double-blind, placebo-controlled study showing statistical improvement of an H(1)-antihistamine in children with seasonal allergic rhinitis in all symptoms throughout the entire treatment period.This randomi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78142c9909cf694563cc392b4b7af7d0
https://pubmed.ncbi.nlm.nih.gov/12704355

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Efficacy and tolerability of once-daily telithromycin compared with high-dose amoxicillin for treatment of community-acquired pneumonia

Autor: A Torres, D van Rensburg, Bruno Leroy, Manickam Rangaraju, E Ruuth, Lars Hagberg

Publikováno v: Infection. 30(6)

Background: This randomized, double-blind study compared the efficacy and tolerability of the new ketolide antimicrobial telithromycin with that of high-dose amoxicillin in the treatment of community-acquired pneumonia (CAP). Patients and Methods: Ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea9c58660be5b593fc2c7b2f9a569d7
https://pubmed.ncbi.nlm.nih.gov/12478329

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In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine

Autor: T A, Thomson, S, Spinella-Jaegle, E, Francesconi, C, Meakin, S, Millet, K L, Flao, H, Hidden, E, Ruuth

Publikováno v: Scandinavian journal of immunology. 56(1)

The objective was to demonstrate that the immunosuppressive agent HR325 (an inhibitor of dihydroorotate dehydrogenase, DHODH) inhibits immunoglobulin (Ig) secretion both in vitro and in vivo and that this effect can be reversed with exogenous uridine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3fb90d1706550da066af15ed04c7399c
https://pubmed.ncbi.nlm.nih.gov/12100469

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Inflammatory cytokine production in interferon-gamma-primed mice, challenged with lipopolysaccharide. Inhibition by SKF 86002 and interleukin-1 beta-converting enzyme inhibitor

Autor: S, Spinelle-Jaegle, P, Devillier, S, Doucet, S, Millet, C, Banissi, A, Diu-Hercend, E, Ruuth

Publikováno v: European cytokine network. 12(2)

Mice challenged with lipopolysaccharide (LPS) produce variable serum levels of pro-inflammatory cytokines, and particularly low levels of interleukin-1 beta (IL-1 beta). Interferon-gamma (IFN-gamma) has been shown to be an important mediator of bacte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7ca1746e566be590c4626f6f0356b97
https://pubmed.ncbi.nlm.nih.gov/11399517

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Potencies of leflunomide and HR325 as inhibitors of prostaglandin endoperoxide H synthase-1 and -2: comparison with nonsteroidal anti-inflammatory drugs

Autor: A P, Curnock, P A, Robson, C M, Yea, D, Moss, S, Gadher, T A, Thomson, R, Westwood, E, Ruuth, R A, Williamson

Publikováno v: The Journal of pharmacology and experimental therapeutics. 282(1)

The relative anti-inflammatory activities of the immunomodulators HR325 and leflunomide, or its active metabolite A77 1726, were examined by determining potencies in vitro on prostaglandin endoperoxide H synthase (PGHS) and in vivo in rat air pouch i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22626f2d8a609b0a3cc88d13782a965e
https://pubmed.ncbi.nlm.nih.gov/9223572

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