Zobrazeno 1 - 10
of 109
pro vyhledávání: '"E, Rands"'
Autor:
C A, Omer, Z, Chen, R E, Diehl, M W, Conner, H Y, Chen, M E, Trumbauer, S, Gopal-Truter, G, Seeburger, H, Bhimnathwala, M T, Abrams, J P, Davide, M S, Ellis, J B, Gibbs, I, Greenberg, K S, Koblan, A M, Kral, D, Liu, R B, Lobell, P J, Miller, S D, Mosser, T J, O'Neill, E, Rands, M D, Schaber, E T, Senderak, A, Oliff, N E, Kohl
Publikováno v:
Cancer research. 60(10)
For Ras oncoproteins to transform mammalian cells, they must be posttranslationally modified with a farnesyl group in a reaction catalyzed by the enzyme farnesyl:protein transferase (FPTase). Inhibitors of FPTase have therefore been developed as pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2912ec44ca2d1ecb77982ce053c4c10a
https://pubmed.ncbi.nlm.nih.gov/10825141
https://pubmed.ncbi.nlm.nih.gov/10825141
Publikováno v:
Public health. 114(1)
To describe the current clinical workload of the modern community paediatrician; to outline the changes in this role over recent years and examine the reasons for these.The design is a retrospective analysis of data routinely collected for contractin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::294c0288c3ad25cc76203ca85e937dee
https://pubmed.ncbi.nlm.nih.gov/10787029
https://pubmed.ncbi.nlm.nih.gov/10787029
Publikováno v:
Cancer research. 55(22)
Farnesyl protein transferase (FPTase) catalyzes the first of a series of posttranslational modifications of Ras required for full biological activity. Peptidomimetic inhibitors of FPTase have been designed that selectively block farnesylation in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2b4fa610c395433431077f4e3e819275
https://pubmed.ncbi.nlm.nih.gov/7585592
https://pubmed.ncbi.nlm.nih.gov/7585592
Autor:
S, Kargman, P, Rousseau, G K, Reid, C A, Rouzer, J A, Mancini, E, Rands, R A, Dixon, R E, Diehl, C, Léveillé, D, Nathaniel
Publikováno v:
Journal of lipid mediators. 7(1)
The U937 human promyelocytic cell line does not express 5-lipoxygenase, but does express 5-lipoxygenase-activating protein (FLAP). U937 cells do not synthesize leukotrienes after stimulation by calcium ionophore A23187. Dimethyl sulfoxide (DMSO) diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab90a3a479fe471dff2efce23b97cea7
https://pubmed.ncbi.nlm.nih.gov/8358023
https://pubmed.ncbi.nlm.nih.gov/8358023
Autor:
J B, Gibbs, D L, Pompliano, S D, Mosser, E, Rands, R B, Lingham, S B, Singh, E M, Scolnick, N E, Kohl, A, Oliff
Publikováno v:
The Journal of biological chemistry. 268(11)
The ras oncogene product, Ras, is synthesized in vivo as a precursor protein that requires post-translational processing to become biologically active and to be capable of transforming mammalian cells. Farnesylation appears to be a critical modificat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a61d4e751384dd9b6c1b30bdb8ee699c
https://pubmed.ncbi.nlm.nih.gov/8463291
https://pubmed.ncbi.nlm.nih.gov/8463291
Autor:
N E, Kohl, R E, Diehl, M D, Schaber, E, Rands, D D, Soderman, B, He, S L, Moores, D L, Pompliano, S, Ferro-Novick, S, Powers
Publikováno v:
The Journal of biological chemistry. 266(28)
Farnesyl-protein transferase (FTase) purified from rat or bovine brain is an alpha/beta heterodimer, comprised of subunits having relative molecular masses of approximately 47 (alpha) and 45 kDa (beta). In the yeast Saccharomyces cerevisiae, two unli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5004aea0d39c9055e985825403b5c4c1
https://pubmed.ncbi.nlm.nih.gov/1918005
https://pubmed.ncbi.nlm.nih.gov/1918005
Autor:
S L, Moores, M D, Schaber, S D, Mosser, E, Rands, M B, O'Hara, V M, Garsky, M S, Marshall, D L, Pompliano, J B, Gibbs
Publikováno v:
The Journal of biological chemistry. 266(22)
Several proteins have been shown to be post-translationally modified on a specific C-terminal cysteine residue by either of two isoprenoid biosynthetic pathway metabolites, farnesyl diphosphate or geranylgeranyl diphosphate. Three enzymes responsible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bdcf7e3bbda5a24ca2290ae56b9b627
https://pubmed.ncbi.nlm.nih.gov/1860864
https://pubmed.ncbi.nlm.nih.gov/1860864
Publikováno v:
The Journal of biological chemistry. 265(18)
The beta-adrenergic receptor (beta AR) contains significant amounts of N-linked carbohydrate. Deletion mutants spanning the four consensus glycosylation sites on the receptor and single amino acid substitutions within the two amino-terminal consensus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::312de201edcd0fa7e0c70066053375e7
https://pubmed.ncbi.nlm.nih.gov/2162359
https://pubmed.ncbi.nlm.nih.gov/2162359
Publikováno v:
Molecular pharmacology. 32(1)
The gene encoding the hamster beta-adrenergic receptor (beta AR) was expressed in mouse C6 glioma cells, a cell line which normally expressed the beta 1 subtype of the receptor. Upon transfection with the hamster beta AR gene, the cells expressed inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::255f736ea625792e65c2d0f4e74f5db6
https://pubmed.ncbi.nlm.nih.gov/3039335
https://pubmed.ncbi.nlm.nih.gov/3039335
Publikováno v:
The Journal of biological chemistry. 263(21)
5-Lipoxygenase has been expressed in a mammalian osteosarcoma cell line transfected with the cloned cDNA for human leukocyte 5-lipoxygenase. Two clonal cell lines derived from the transfected cells expressed the enzymatic activity. When incubated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27df92da451de2c9a75ffde64c25a25a
https://pubmed.ncbi.nlm.nih.gov/3164719
https://pubmed.ncbi.nlm.nih.gov/3164719