Výsledky vyhledávání - "E, Randerath"

Genotoxicity of complex PAH mixtures recovered from contaminated lake sediments as assessed by three different methods

Autor: K, Randerath, E, Randerath, G D, Zhou, N, Supunpong, L Y, He, T J, McDonald, K C, Donnelly

Publikováno v: Environmental and molecular mutagenesis. 33(4)

Although human exposure generally occurs to mixtures of chemicals, limited toxicological information is available to characterize the potential interactions of the components of environmental mixtures. This study was conducted to compare the genotoxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70043a071ebb0397881bc27621edf76c
https://pubmed.ncbi.nlm.nih.gov/10398378

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High levels of endogenous DNA adducts (I-compounds) in pig liver. Modulation by high cholesterol/high fat diet

Autor: S V, Vulimiri, G D, Zhou, K, Randerath, E, Randerath

Publikováno v: Mutation research. 422(2)

I (indigenous)-compounds are bulky endogenous DNA adducts which are detected by 32P-postlabeling in unexposed animals. I-compound levels in rodents depend on age, species, strain, gender, tissue, diet, and chemical exposure. There are two classes of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a6d31973085f456915c9b6ce183d598
https://pubmed.ncbi.nlm.nih.gov/9838171

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Enhanced levels in neonatal rat liver of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxydeoxyguanosine), a major mutagenic oxidative DNA lesion

Autor: Guo-Dong Zhou, S A Monk, E Randerath, Kurt Randerath

Publikováno v: Carcinogenesis. 18(7)

The purpose of this study was to determine whether the level of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) (8-oxo-dG), a major mutagenic DNA oxidation product, is enhanced in newborn rat liver DNA as a consequence of oxidative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3af4df68124dafbc0add8e184a4687
https://pubmed.ncbi.nlm.nih.gov/9230290

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Comparative 32P-postlabeling analysis of exogenous and endogenous DNA adducts in mouse skin exposed to a wood-preserving waste extract, a complex mixture of polycyclic and polychlorinated chemicals

Autor: K, Randerath, G D, Zhou, E, Randerath, S H, Safe, K C, Donnelly

Publikováno v: Environmental and molecular mutagenesis. 29(4)

Wood preserving waste (WPW) sites contain numerous toxic compounds, including phenols, polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzodioxins, and dibenzofurans. Previous in vitro and in vivo 32P-postlabeling studies showed the induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2815f2ff0aa5c2e1401391dd534dcf9d
https://pubmed.ncbi.nlm.nih.gov/9212788

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Age-dependent DNA modifications (I-compounds): Effects of carcinogenesis and oxidative stress

Autor: E. Randerath, K. Randerath, Jian Chang

Publikováno v: Oxidative Stress and Aging ISBN: 9783034873390

I-compounds are bulky covalent DNA modifications which increase with age in tissues of unexposed laboratory animals and arc derived from endogenous DNA-reactive intermediates of nutrient and oxygen metabolism. Profiles and levels of I-compounds depen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9cdbf67b73ab46bbcadf8bfb593a5fe
https://doi.org/10.1007/978-3-0348-7337-6_10

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