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Publikováno v:
Clinical Neuropharmacology. 24:214-220
The efficacy and safety of two dosages of tolcapone were compared in a 12-week crossover trial involving 118 nonfluctuating patients with PD on a stable dose of levodopa (L-Dopa). At trial onset, all patients received open-label tolcapone 100 mg thre
Publikováno v:
American journal of neurodegenerative disease. 2(3)
The subventricular zone retains its neurogenic capacity throughout life and, as such, is often considered a potential source for endogenous repair in neurodegenerative disorders. Because dopamine is believed to stimulate adult neurogenesis, we looked
Publikováno v:
European Neuropsychopharmacology. 6:S4-99
Publikováno v:
The Canadian Journal of Psychiatry. 37:503-509
This article reviews the historical and terminological origins of dysmorphophobia from Herodotus to today. It explains the differences pointed out by many authors, including the DSM-III-R, between body dismorphic disorder and delusional disorder soma
Publikováno v:
Movement Disorders. 7:132-136
Following the demonstration of an anti-tremor effect of ethosuximide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) monkey model, we have tested the effect of this drug in 10 patients with typical parkinsonian tremor. Six patients suffere
Autor:
E Pourcher, M.J. Filteau, P Baruch, J. Mathieu, F Bédard, Pierre Vincent, Roch-Hugo Bouchard, N. Simard
Publikováno v:
European Psychiatry. 7:109-113
Brain alterations have been sought since the beginning of the century to explain the ‘dementia’ of dementia præcox. Kraepelin suggested in 1913 that it might have its internal origins in early childhood, while Southard (1915) considered likely a
Autor:
R H, Bouchard, C, Mérette, E, Pourcher, M F, Demers, J, Villeneuve, M H, Roy-Gagnon, Y, Gauthier, D, Cliche, A, Labelle, M J, Filteau, M A, Roy, M, Maziade
Publikováno v:
Journal of clinical psychopharmacology. 20(3)
This study compared the long-term (12 months) effectiveness of risperidone (RP) with that of conventional neuroleptics (CNs) in a population with chronic schizophrenia who had shown suboptimal response to CNs. A randomized, open, parallel, multicente
Autor:
L. Bond, E. Pourcher
Publikováno v:
Sleep Medicine. 14:e235
Introduction The aim of this study was to assess the frequency of self-reported compulsive behaviours, depressive and stress symptoms and sleep disorders in a population of Restless legs patients treated with DA agonists. Reports by Tippmann-Peikert
Publikováno v:
Canadian journal of psychiatry. Revue canadienne de psychiatrie. 39(9)
This article reviews the main clinical indicators linking the basal nuclei to obsessive compulsive disorder (OCD). Various pathologies associated with lesions of the basal nuclei are examined, followed by a review of neuropharmacological, brain imagi